<scp>pH</scp>‐responsive alginate–pectin polymeric rafts and their characterization

Hanif, Muhammad; Abbas, Ghulam

doi:10.1002/adv.21808

Cited by 22 publications

(14 citation statements)

References 23 publications

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“…Floating lag time and a total floating duration of rafts were evaluated using a modified United States Pharmacopeia Type II dissolution apparatus. Results showed that the formulation had a significant potential to be considered as a raft forming formulation for the treatment of GORD …”

Section: Resultsmentioning

confidence: 99%

“…Results showed that the formulation had a significant potential to be considered as a raft forming formulation for the treatment of GORD. 73 The chemical characteristics of alginate rafts for good raft performance were measured to explain how the physicochemical properties of the material used in formulations have an impact on its raft-forming capability. The formulations investigated were GDA, Gaviscon Original, Peptac Liquid, Algycon tablets, Maalox RefluRapid liquid suspension, Mylan Liquid Suspension, and Rennie Duo liquid suspension.…”

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confidence: 99%

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Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic review

Yousaf

Nirwan

Smith

et al. 2019

J of Applied Polymer Sci

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Gastroesophageal reflux disease (GORD) is a common condition induced by unwarranted reflux of gastric and duodenal contents into the esophagus, and insufficient clearance of refluxate from it. Pharmaceutical formulations possessing raft‐forming capability offers an excellent alternative to conventional treatment options to treat uncomplicated GORD. These formulations typically contain a polymer, which performs distinctively upon contact with gastric acid and develops a foam‐like structure that can float on gastric contents. This review aims to feature research articles and patents that cover this topic. After undergoing a standardized literature search following preferred reporting items for systematic reviews and meta‐analyses guidelines, we have included 38 research articles and 18 patents describing the role of raft‐forming polymers in the treatment of GORD. This is a comprehensive review of formulation/testing of raft‐forming polymers. As expected, the majority of the studies focused on alginate; however, fewer studies have reported the use of pectin, xanthan gum, and raw psyllium fibers (husk). Moreover, it can be concluded from this comprehensive systematic review that a detailed characterization of raft‐forming formulations, type, and concentration of used active and inactive materials and different formulations factors are essential for the development of successful anti‐reflux raft‐forming formulations. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48012.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic review

Yousaf

Nirwan

Smith

et al. 2019

J of Applied Polymer Sci

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“…MRT ¼ AUMC AUC (9) where F, Vd, and k are administered dose fraction, volume of distribution, and rate constant, respectively. K a and K e are rate constants for absorption and elimination, respectively.…”

Section: Discussionmentioning

confidence: 99%

<p>Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation</p>

Hanif¹,

Shah²,

Rasul³

et al. 2020

IJN

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Background: Bisphosphonates have very low bioavailability and cause irritation of the esophagus and stomach. This study was planned to improve the oral bioavailability of ibandronate through the formation of a raft in the stomach. Bisphosphonate-induced irritation of the esophagus and stomach is prevented by the formation of a raft. Materials and Methods: The nanostructured raft was developed through the use of nanosized citrus pectin (NCP). The particle size of NCP was measured by zeta sizer and SEM. The percentage of NCP and the neutralization profile of raft was studied. The ibandronate, polymers, and the developed formulation were characterized by FTIR, XRD, TGA, and DSC. The release of ibandronate was studied in 0.1 N HCl, 0.5 N HCl, 1 N HCl, and simulated gastric fluid (SGF) and a cell viability study was performed using Caco-2 cells. The PPR5 formulation and Bonish 150 mg tablets were selected as test and reference formulations, respectively, for pharmacokinetic study. Twelve healthy albino rats were taken and divided into two groups using a Latin square crossover design, and the blood samples were collected for 24 hours. Results: The SEM image showed that the particle size of NCP was 159 nm. The raft of PPR5 showed 94% NCP and 45 minutes duration of neutralization. The FTIR and XRD showed chemical stability and a uniform distribution of ibandronate in the raft. The TGA and DSC indicated the thermal stability of formulation. The release of 99.87% ibandronate at 20 minutes was observed in the SGF. The values of C max for the reference and test formulations were 493±0.237 ng/mL and 653±0.097 ng/mL, respectively. The AUC (0-t) of the reference and test formulations was 3708.25±3.418 ng/mL.h and 6899.25±3.467 ng/mL.h, respectively. Conclusion: The NCP has been successfully prepared from citrus pectin and has shown effective porous raft formation. The bioavailability of the ibandronate from newly developed PPR5 was higher than the already marketed formulation.

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“…Bacterial cellulose–high methylated pectin films were developed to encapsulate and release biomacromolecules such as human serum albumin (Cacicedo et al, ). Alginate–pectin polymeric rafts showed pH‐responsive property and showed potential for the treatment of gastro‐esophageal reflux disorders (Hanif & Abbas, ). Chitosan, due to its negative charge, was also widely used to prepare different nanostructures, in combination with pectin.…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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pH‐responsive alginate–pectin polymeric rafts and their characterization

Cited by 22 publications

References 23 publications

Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic review

Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic review

<p>Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation</p>

Carbohydrate‐based nanomaterials for biomedical applications

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