2023
DOI: 10.15252/embr.202357234
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PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability

Matteo Burigotto,
Vincenza Vigorito,
Colin Gliech
et al.

Abstract: Abstract53BP1 acts at the crossroads between DNA repair and p53‐mediated stress response. With its interactors p53 and USP28, it is part of the mitotic surveillance (or mitotic stopwatch) pathway (MSP), a sensor that monitors the duration of cell division, promoting p53‐dependent cell cycle arrest when a critical time threshold is surpassed. Here, we show that Polo‐like kinase 1 (PLK1) activity is essential for the time‐dependent release of 53BP1 from kinetochores. PLK1 inhibition, which leads to 53BP1 persist… Show more

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