<scp>PVA</scp>/<scp>PMMA</scp> polymer blended composite electrospun nanofibers mat and their potential use as an anti‐biofilm product

Singh, Manvi; Chauhan, Deepika; Das, Ayan Kumar; Iqbal, Zeenat; Solanki, Pratima R.

doi:10.1002/app.50340

Cited by 14 publications

(5 citation statements)

References 35 publications

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“…These plates were kept for incubation at 37 ± 0.5 °C for 2 days. Fungal growth was observed in the plates, and the zone of inhibition was measured using a Vernier caliper …”

Section: Methodsmentioning

confidence: 99%

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Investigation of Luliconazole-Loaded Mucoadhesive Electrospun Nanofibers for Anticandidal Activity in the Management of Vaginal Candidiasis

Vidyadhari,

Singh,

Singh

et al. 2023

ACS Omega

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In this study, we fabricated and evaluated luliconazoleloaded electrospun nanofibers for anticandidal activity in the management of vaginal candidiasis. Polycaprolactone (PCL)/gelatin nanofibers were designed by the electrospinning technique, and the Box−Behnken design (BBD) was adopted for optimization to get tailored fibers. The luliconazole (LCZ) drug was mixed into different concentrations (2.5, 5, 7.5, and 10%) of tea tree oil (TT oil) and loaded into the PCL/gelatin nanofibrous mats. The effective anticandidal potential of nanofiber samples were analyzed by the disk-diffusion method. Scanning electron microscopy (SEM), Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), XRD analysis, and in silico study were performed. The entrapment efficiency, swelling degree, mechanical strength, contact angle, mucoadhesion, drug release, and permeation study were assessed. The average diameter of the PCL/gelatin-optimized nanofiber was 153 nm. SEM reflected that the fabricated nanofibers were uniform and bead-free. FTIR and DSC analyzed the interaction and physical entrapment of the drug in the polymeric fibers. The entrapment efficiency of the drug-loaded nanofiber was found to be 89.2 ± 0.8%. Maximum swelling percentages at 4 h were 40.8, 18.9, and 14.0% and contact angles were 46.5°, 62.95°, and 65.78°for the blank, TT oil-loaded, and drug-loaded nanofiber, respectively, which indicated the hydrophilic nature of the fibers. The drug-loaded nanofiber had a high tensile strength with satisfactory mucoadhesive property that led to its adhesion to the vaginal mucosa with no tear. The drug-loaded nanofiber had a cumulative drug release of 67.7 ± 3.4% in 48 h, and the 12.8 ± 0.53 mm of zone of inhibition (ZOI) in 48 h illustrated an effective anticandidal activity. The TT oil-loaded nanofiber also exhibited a small ZOI of 4.3 ± 0.30 mm, indicating a synergistic effect to the antifungal activity of the drug-loaded nanofiber. LCZ-loaded nanofibers can emerge as a novel approach for vaginal drug delivery in the treatment of candida infection. Thus, this pharmaceutical investigation can help in formulating preclinical and clinical models.

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“…These plates were kept for incubation at 37 ± 0.5 °C for 2 days. Fungal growth was observed in the plates, and the zone of inhibition was measured using a Vernier caliper …”

Section: Methodsmentioning

confidence: 99%

“…Fungal growth was observed in the plates, and the zone of inhibition was measured using a Vernier caliper. 41…”

Section: ■ Conclusionmentioning

confidence: 99%

Investigation of Luliconazole-Loaded Mucoadhesive Electrospun Nanofibers for Anticandidal Activity in the Management of Vaginal Candidiasis

Vidyadhari,

Singh,

Singh

et al. 2023

ACS Omega

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“…The universal affliction of infectious diseases has substantially enhanced due to the evolving and re-emerging progress of resistant strains of microbes. Recent reports show that biofilm-producing bacterial strains are related to more than 65% of bacterial infections [ 8 , 9 ]. Such challenging infections necessitate strategic therapeutic and prophylactic drug intercessions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Bio-Based Polybenzoxazine and Its Antibiofilm and Anticorrosive Activities

et al. 2023

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Candida albicans are highly widespread pathogenic fungi in humans. Moreover, its developed biofilm causes serious clinical problems, leading to drug failure caused by its inherent drug tolerance. Hence, the inhibition of biofilm formation and virulence characteristics provide other means of addressing infections. Polymer composites (PCs) derived from natural products have attracted increasing interest in the scientific community, including antimicrobial applications. PCs are a good alternative approach to solving this challenge because of their excellent penetration power inside biofilms. The main objectives of this study were to synthesize a novel curcumin-based polybenzoxazine polymer composite (poly(Cu-A) PC) using Mannich condensation reaction and evaluate their potency as an antibiofilm and anticorrosive candidate against C. albicans. In addition, their anticorrosive efficacy was also explored. PC exhibited significant antibiofilm efficacy versus C. albicans DAY185 by the morphologic changing of yeast to hyphae, and>90% anticorrosive efficacy was observed at a higher dose of PC. These prepared PC were safe in vivo against Caenorhabditis elegans and Raphanus raphanistrum. The study shows that a polybenzoxazine polymer composite has the potential for controlling biofilm-associated fungal infections and virulence by C. albicans, and opens a new avenue for designing PCs as antifungal, anticorrosive agents for biofilm-associated fungal infections and industrial remediation.

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“…In recent years, there are more and more preparation processes of electrospinning. 28 Although electrospinning is developing from a single-fluid process 29 to coaxial, 30 tri-axial, 31 modified triaxial, 32 side-byside, 33 and some other complicated processes, 34 the main stream is still the single-fluid blending electrospinning. 35 The blending process is not only easy to be conducted, but also can be facilely to tailor components and compositions of the composite nanofibers for functional applications.…”

Section: Introductionmentioning

confidence: 99%

Electrospun polylactic acid/sulfadiazine sodium/proteinase nanofibers and their applications in treating frostbite

Ding

Zhou

Fan

et al. 2021

J of Applied Polymer Sci

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In this study, polylactic acid (PLA)/sulfadiazine sodium/proteinase K composite nanofibers were prepared by electrospinning, and their morphology was observed by scanning electron microscope. The novel nanofibers were characterized by Fourier transform infrared spectroscopy and drug release curve. The activity of different groups of drugs loaded nanofibers in frostbite wound of rats was studied and compared with the blank control group. Hematoxylin-eosin staining and transmission electron microscope were used to access the histological changes of frostbite wounds on the back of rats before and after treatment.CD31 fluorescence staining was used to track the reconstruction and improvement of blood vessels in tissues. The results revealed that the drug release rate of PLA/sulfadiazine sodium/proteinase K nanofibers group was more than 50% at 1 h, and the cumulative drug release rate was more than 88% at 168 h, and CD31 fluorescence showed that its vascular density was 13.27% ± 0.9%, which was significantly higher than that of other groups. Therefore, PLA/sulfadiazine sodium/proteinase K composite nanofibers could promote the healing of frostbite wounds, which indicated the increase of capillaries and the regeneration of hair follicles. PLA/sulfadiazine sodium/proteinase K composite nanofibers have great potential in the application of frostbite.

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PVA/PMMA polymer blended composite electrospun nanofibers mat and their potential use as an anti‐biofilm product

Cited by 14 publications

References 35 publications

Investigation of Luliconazole-Loaded Mucoadhesive Electrospun Nanofibers for Anticandidal Activity in the Management of Vaginal Candidiasis

Investigation of Luliconazole-Loaded Mucoadhesive Electrospun Nanofibers for Anticandidal Activity in the Management of Vaginal Candidiasis

Synthesis of Bio-Based Polybenzoxazine and Its Antibiofilm and Anticorrosive Activities

Electrospun polylactic acid/sulfadiazine sodium/proteinase nanofibers and their applications in treating frostbite

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