SARS‐CoV‐2–associated Guillain‐Barré syndrome with dysautonomia

Abstract

Coronavirus disease 2019 , caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), is associated with Guillain-Barré syndrome (GBS). [1][2][3][4][5][6][7][8] We describe a patient with quadriplegic GBS with dysautonomia preceded by mild COVID-19-induced diarrhea.A 72-year-old man with coronary artery disease, hypertension, and alcohol abuse presented to a tertiary hospital with symmetric paresthesias and ascending appendicular weakness. Seven days earlier he had mild diarrhea, anorexia, and chills, without fever or respiratory symptoms. This condition resolved in 5 days. Weakness began 6 days after diarrhea, and the patient presented 1 day after neurological symptom onset.On admission, he was afebrile with normal vital signs. Mental status and cranial nerves were normal. Strength was 4/5 for neck flexion, and 3/5 for proximal upper and lower extremities bilaterally. Tendon

Guillain-Barre syndrome during COVID-19 pandemic: an overview of the reports

“…After the diagnosis of COVID-19, some GBS cases were admitted to the ICU [30,31,33,43]. Therefore, the correct and timely diagnosis of GBS associated with COVID-19 can prevent its progress.…”

“…Intravenous immunoglobulin therapy was performed for all patients. • Decreased forces, MRC grade of 2/5 at proximal and 3/5 at distal lower limbs, and 4/5 in both arms • Deep tendon reflexes were absent in both legs and decreased to 1+ in the upper extremities 17 [43] • Symmetric paresthesias…”

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

“…Pascual-Goñi E et al [194] [63], [101], [191], [215], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229] Abbreviation: M: Male, F: Female, NR: Not reported Abbreviation: M: Male, F: Female, NR: Not reported J et al [127], reported a 69-year-old woman with acute necrotizing myelitis. Optic Neuritis after COVID-19 was reported in only one patient.…”

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

“… EMG/NCS (day 13): prolonged right ulnar & bilateral tibial/peroneal motor distal latencies with slow conduction velocities, absent F waves, ↓ right ulnar/peroneal CMAP amplitudes, absent right ulnar/bilateral sural SNAPs, normal EMG with poor effort, overall suggestive of demyelination. IVIG (0.4 g/kg/day for 4 days) Poor, prolonged ICU (> 1 month) stay ( Su et al, 2020 ) Bursa, Turkey 53, F 3-day history of dysarthria associated with progressive weakness and numbness of the lower extremities 3-day history of dysarthria associated with progressive weakness and numbness of the lower extremities Three-day dysarthria & progressive lower limbs weakness & numbness, & areflexia No symptoms prior, mild fever (day 5 after neurological symptoms) Admission: mild neutropenia, normal electrolytes, LFT, RFT & CRP. Day 5: mild lymphocytopenia, ↑ CRP, positive COVID-19 nasopharyngeal swab.…”