<scp>SATB</scp>1 promotes tumor metastasis and invasiveness in oral squamous cell carcinoma

Yc, Li; Bu, LL; Mao, Lijun; Ma, SR; Jf, Liu; Yu, GT; Deng, Wei; Zhang, WF; Sun, Zhenchang

doi:10.1111/odi.12602

Cited by 13 publications

(10 citation statements)

References 36 publications

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“…Interestingly, SATB1 is slightly downregulated in all analyzed pathologies (Oncomine results). Of note, high SATB1 expression is predictive of poor prognosis in oral, laryngeal, and esophageal SCCs [ 198 , 199 , 200 ]. HBP1 is upregulated in cSCCs and BCCs differently from HNSCCs and oSCCs ( Table 2 and Table 3 ).…”

Section: P16 Ink4a and Non-melanomentioning

confidence: 99%

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

D’Arcangelo

Tinaburri

Dellambra

2017

IJMS

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The epidermis is a self-renewing tissue. The balance between proliferation and differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) population in the epidermis during life. Aging and cancer may be considered related endpoints of accumulating damages within epidermal self-renewing compartment. p16INK4a is a potent inhibitor of the G1/S-phase transition of the cell cycle. p16INK4a governs the processes of SC self-renewal in several tissues and its deregulation may result in aging or tumor development. Keratinocytes are equipped with several epigenetic enzymes and transcription factors that shape the gene expression signatures of different epidermal layers and allow dynamic and coordinated expression changes to finely balance keratinocyte self-renewal and differentiation. These factors converge their activity in the basal layer to repress p16INK4a expression, protecting cells from senescence, and preserving epidermal homeostasis and regeneration. Several stress stimuli may activate p16INK4a expression that orchestrates cell cycle exit and senescence response. In the present review, we discuss the role of p16INK4a regulators in human epidermal SC self-renewal, aging and cancer.

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Section: P16 Ink4a and Non-melanomentioning

confidence: 99%

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

D’Arcangelo

Tinaburri

Dellambra

2017

IJMS

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“…4B). It is well known that EMT plays a critical role in the invasion and metastasis of OSCC cells (27). In this study, we thus assessed the effect of H19 on the expression of EMT related-genes.…”

Section: Knockdown Of H19 Inhibits the Migration And Invasion Of Osccmentioning

confidence: 99%

Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma

Hong

Sui

et al. 2018

Int J Oncol

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Long non-coding RNAs (lncRNAs) have been shown to play pivotal roles in various types of human cancer, including oral squamous cell carcinoma (OSCC). However, the potential mechanisms of action of lncRNAs in OSCC remain to be fully elucidated. The aim of the present study was to further explore the potential mechanisms of action of lncRNAs in OSCC. We first analyzed Gene Expression Omnibus (GEO) datasets to investigate aberrantly expressed lncRNAs which may be involved in the development of OSCC. Reverse transcription‑quantitative PCR (RT‑qPCR) was performed to analyze the expression levels of lncRNA H19. In addition, the correlation between H19 expression and the clinical characteristics and prognosis of patients with OSCC was statistically analyzed. The effects of H19 expression on OSCC cells were examined by using overexpression and RNA interference approaches in vitro and in vivo. To examine the competitive endogenous RNA (ceRNA) mechanisms, bioinformatics analysis and luciferase reporter assay were performed. In addition, the correlation between H19 and microRNA (miR)‑138 was detected. H19 was found to be upregulated in OSCC tissues and its high expression level was associated with the TNM stage and nodal invasion, and also correlated with a shorter overall survival of patients with OSCC. The knockdown of H19 significantly inhibited OSCC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), and induced apoptosis in vitro; it also suppressed subcutaneous tumor growth in vivo. In addition, H19 was found to regulate the expression of oncogene enhancer of zeste homolog 2 (EZH2) by competing with miR‑138; the inhibition of miR‑138 attenuated the inhibitory effects of H19 knockdown on OSCC cells. On the whole, our findings suggest that H19 functions as an oncogene by inhibiting miR‑138 and facilitating EZH2 expression in OSCC. Thus, lncRNA H1 may represent a potential therapeutic target for OSCC.

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“…In addition, dysregulation of SATB1 expression also results in oncogenesis. SATB1 promotes tumor metastasis in oral squamous cell carcinoma [ 36 ]. SATB1 is correlated with breast cancer [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

LncSHRG promotes hepatocellular carcinoma progression by activating HES6

et al. 2017

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Hepatocellular carcinoma, one of the most common cancers, leads to mass mortality worldwide currently. However, the underlying mechanism of its oncogenesis remains to be elucidated. Here we identified that a long noncoding RNA, lncSHRG, was greatly upregulated in human hepatocellular carcinoma samples. We found that lncSHRG was essential for liver cancer cell proliferation and tumor propagation in mice. In mechanism, lncSHRG recruits SATB1 to bind to HES6 promoter and initiates HES6 expression. HES6, which is highly expressed in hepatocellular carcinoma, promotes tumor cell proliferation. High expression level of HES6 is positively correlated with clinical severity and poor prognosis of people with hepatocellular carcinoma. Altogether, our research provides a new insight on the mechanism of hepatocellular carcinoma progression.

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SATB1 promotes tumor metastasis and invasiveness in oral squamous cell carcinoma

Abstract: These findings suggest SATB1 may play an important role in OSCC invasiveness and metastasis.

Cited by 13 publications

References 36 publications

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma

LncSHRG promotes hepatocellular carcinoma progression by activating HES6

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