<scp>Sex‐specific</scp> differences in telomere length of patients with primary knee osteoarthritis

Kuszel, Lukasz; Trzeciak, Tomasz; Begier‐Krasinska, Beata; Richter, Magdalena; Li, Jian; Czarny‐Ratajczak, Malwina

doi:10.1111/jcmm.18107

Cited by 3 publications

(1 citation statement)

References 42 publications

(102 reference statements)

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“…Of note, sex/gender differences could be observed in the telomere length of leukocytes of 310 patients with knee osteoarthritis undergoing total knee arthroplasty versus 302 individuals free from the disease and in the cartilage of 57 osteoarthritis patients [64]. Telomere attrition is an important biomarker of ageing [65].…”

Section: Sex-and Gender-specific Physiopathology Of Osteoarthritismentioning

confidence: 99%

Investigating and Practicing Orthopedics at the Intersection of Sex and Gender: Understanding the Physiological Basis, Pathology, and Treatment Response of Orthopedic Conditions by Adopting a Gender Lens: A Narrative Overview

Biz,

Khamisy-Farah,

Puce

et al. 2024

Biomedicines

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In the biomedical field, the differentiation between sex and gender is crucial for enhancing the understanding of human health and personalizing medical treatments, particularly within the domain of orthopedics. This distinction, often overlooked or misunderstood, is vital for dissecting and treating musculoskeletal conditions effectively. This review delves into the sex- and gender-specific physiology of bones, cartilage, ligaments, and tendons, highlighting how hormonal differences impact the musculoskeletal system’s structure and function, and exploring the physiopathology of orthopedic conditions from an epidemiological, molecular, and clinical perspective, shedding light on the discrepancies in disease manifestation across sexes. Examples such as the higher rates of deformities (adolescent idiopathic and adult degenerative scoliosis and hallux valgus) in females and osteoporosis in postmenopausal women illustrate the critical role of sex and gender in orthopedic health. Additionally, the review addresses the morbidity–mortality paradox, where women, despite appearing less healthy on frailty indexes, show lower mortality rates, highlighting the complex interplay between biological and social determinants of health. Injuries and chronic orthopedic conditions such osteoarthritis exhibit gender- and sex-specific prevalence and progression patterns, necessitating a nuanced approach to treatment that considers these differences to optimize outcomes. Moreover, the review underscores the importance of recognizing the unique needs of sexual minority and gender-diverse individuals in orthopedic care, emphasizing the impact of gender-affirming hormone therapy on aspects like bone health and perioperative risks. To foster advancements in sex- and gender-specific orthopedics, we advocate for the strategic disaggregation of data by sex and gender and the inclusion of “Sexual Orientation and Gender Identity” (SOGI) data in research and clinical practice. Such measures can enrich clinical insights, ensure tailored patient care, and promote inclusivity within orthopedic treatments, ultimately enhancing the precision and effectiveness of care for diverse patient populations. Integrating sex and gender considerations into orthopedic research and practice is paramount for addressing the complex and varied needs of patients. By embracing this comprehensive approach, orthopedic medicine can move towards more personalized, effective, and inclusive treatment strategies, thereby improving patient outcomes and advancing the field.

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Section: Sex-and Gender-specific Physiopathology Of Osteoarthritismentioning

confidence: 99%

Investigating and Practicing Orthopedics at the Intersection of Sex and Gender: Understanding the Physiological Basis, Pathology, and Treatment Response of Orthopedic Conditions by Adopting a Gender Lens: A Narrative Overview

Biz,

Khamisy-Farah,

Puce

et al. 2024

Biomedicines

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Leukocytes telomere length as a biomarker of adverse drug reactions induced by Osimertinib in advanced non-small cell lung cancer

Trachu,

Reungwetwattana,

Meanwatthana

et al. 2024

Sci Rep

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This study aimed to measure relative telomere length (RTL) in blood leukocytes of advanced-stage NSCLC patients either with or without Osimertinib-induced ADRs and determine whether RTL could serve as a biomarker of Osimertinib-induced ADRs. Blood leukocytes RTL were measured in 63 advanced-stage NSCLC patients and 62 age-matched healthy controls using real-time polymerase chain reaction. In patients with advanced-stage NSCLC, RTL was significantly shorter than that in healthy controls (P < 0.001). Compared to patients without ADRs and those with mild/moderate ADRs, patients with severe ADRs exhibited significantly decreased RTL (P < 0.001, P < 0.001, respectively). ROC curve analysis uncovered a diagnostic value of RTL as a biomarker of Osimertinib-induced ADRs (AUC = 1.000, P < 0.001). Kaplan-Meier analysis revealed a significant association between shorter RTL and increased cumulative incidence of Osimertinib-induced ADRs in patients with advanced-stage NSCLC (P < 0.001). Shorter RTL in blood leukocytes would reflect the occurrence of Osimertinib-induced ADRs and might emerge as a promising biomarker for identifying advanced-stage NSCLC patients who are at risk of experiencing Osimertinib-induced ADRs, particularly those with severe ADRs.

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Molecular basis of senescence in osteoarthritis

Lawson,

Ritchison

2024

Asia Pac J Surg Exp & Pathol

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Osteoarthritis (OA) is a multifaceted degenerative joint disorder with substantial global socioeconomic implications. Cellular senescence, defined by permanent cell cycle arrest, has been identified as a critical contributor to OA progression, driving the disruption of cartilage homeostasis and structural integrity. Here, we first delve into the molecular triggers of senescence in OA, including impaired DNA damage response, telomere shortening, mitochondrial dysfunction, oxidative and autophagic stresses, epigenetic modifications, and dysregulated sirtuins and noncoding RNAs. These factors collectively contribute to the establishment of a senescent phenotype in joint tissues, perpetuating the degenerative processes observed in OA. Later, we present the pro-inflammatory senescence-associated secretory phenotype (SASP) as a driving force behind senescence-mediated OA progression that fuels chronic inflammation via the release of pro-inflammatory cytokines, chemokines, and matrix-degrading enzymes, disrupts tissue repair mechanisms, and alters the microenvironment to favor catabolic processes, further exacerbating joint degeneration. The interplay between these factors highlights the complexity of senescence-driven degeneration in OA, underscoring the need for deeper insights into molecular basis of the disease. This review aims to illuminate these mechanisms, providing a foundation for understanding the cellular and molecular pathways that drive senescence in OA and identifying knowledge gaps to guide future research on this pervasive disease.

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Sex‐specific differences in telomere length of patients with primary knee osteoarthritis

Cited by 3 publications

References 42 publications

Investigating and Practicing Orthopedics at the Intersection of Sex and Gender: Understanding the Physiological Basis, Pathology, and Treatment Response of Orthopedic Conditions by Adopting a Gender Lens: A Narrative Overview

Investigating and Practicing Orthopedics at the Intersection of Sex and Gender: Understanding the Physiological Basis, Pathology, and Treatment Response of Orthopedic Conditions by Adopting a Gender Lens: A Narrative Overview

Leukocytes telomere length as a biomarker of adverse drug reactions induced by Osimertinib in advanced non-small cell lung cancer

Molecular basis of senescence in osteoarthritis

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