SNP rs7770370 in HLA‐DPB1 loci as a major genetic determinant of response to booster hepatitis B vaccination: Results of a genome‐wide association study

Abstract

Our results showed that rs7770370 was the most significant genetic factor of response to HB booster. The rs7770370 and nearby SNPs may also contribute to the long-term immunological memory against HB vaccination.

GWAS identifying HLA‐DPB1 gene variants associated with responsiveness to hepatitis B virus vaccination in Koreans: Independent association of HLA‐DPB1*04:02 possessing rs1042169 G ‐ rs9277355 C ‐ rs9277356 A

“…The association of DPB1*05:01 with undetectable prebooster anti‐HBs levels was represented, which was in accordance with our study . However, among the 14 significant SNPs for HB vaccine response in other Asian populations, only 6 SNPs were identified as associated factors for anti‐HBs Ab levels in the present GWAS, with 31‐74th place significance rankings (Table ) . It is not surprising to observe concordant or contradictory results among the various study subjects and populations.…”

“…These findings facilitated GWASs on the HB vaccine response. Wu et al demonstrated that rs7770370 in HLA‐DPB1 is the most significant genetic factor for a lower risk of nonresponse to booster HB vaccination in Taiwanese adolescents. Two HLA‐DPB1 alleles ( HLA‐DPB1*04:02 and HLA‐DPB1*05:01 ), plus five HLA‐DRB1‐DQB1 haplotypes and the BTNL2 gene, were associated with the HB vaccine response in Japanese individuals according to Nishida's study …”

Personalized vaccinology: A review

“…For example, candidate and GWAS immunogenetic and phamacogenetic studies have identified polymorphisms in HLA, KIR, MICA, and BTN genes associated with immune responses to pathogens causing disease in humans, such as hepatitis C [16] , Mycobacterium leprae [17] , [18] , human immunodeficiency virus [19] , and measles [20] , [21] , [22] . Similar studies have identified novel genes impacting immune responses to vaccines, including hepatitis B, rubella, influenza A, smallpox, anthrax, and mumps [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] . Our gene association studies of measles-mumps-rubella (MMR) vaccines have demonstrated that inter-individual variations in measles vaccine virus-induced humoral and cellular responses are significantly associated with polymorphisms in immune response genes and, together with HLA alleles, explain ∼30% of the inter-individual variability in humoral response [5] , [34] , [35] , [36] .…”

Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies

“…The third GWAS used subjects with detectable and undetectable (> or < 1 mIU/mL, respectively) post-booster antibody titers from a cohort of booster vaccine recipient Taiwanese adolescents who had not responded to primary vaccination as infants[ 81 ]. Significant associations were mapped to the HLA-DP locus.…”

“…The lead SNP rs7770370 was in strong LD with rs9277535. HLA-DPB1 alleles *02:01 , *02:02 , *03:01 , *04:01 and *14:01 (encoding 84GGPM87) were associated with vaccine response, whereas *05:01 and *09:01 (encoding 84DEAV87) were associated with vaccine nonresponse[ 74 , 81 ]. These associations were further confirmed in a Japanese population[ 82 ].…”