<scp>SOSTDC1</scp> acts as a tumor inhibitor in acute myeloid leukemia by downregulating the Wnt/β‐catenin pathway

Li, Chengliang; Wang, Minjuan; Shi, Yingpeng; Xin, Hong

doi:10.1002/tox.23540

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…Rbm47, a central mediator of mRNA alternative splicing and stability, has been elaborated to suppress Wnt activity in cancer cells via maintaining AXIN1 or DKK1 mRNA stability ( Vanharanta et al, 2014 ; Shen et al, 2020 ). Moreover, Sostdc1 has been documented to negatively modulate Wnt signaling ( Li et al, 2022a ). These imply that inhibition of Rbm47 or Sostdc1 may mitigate postoperative neurocognitive disorder.…”

Section: Discussionmentioning

confidence: 99%

Decoding competitive endogenous RNA regulatory network in postoperative cognitive dysfunction

et al. 2022

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Postoperative cognitive dysfunction (POCD) is a common postoperative neurological complication in elderly patients. Circular RNAs (circRNAs) are abundant in the mammalian brain and can probably regulate cognitive function. However, the competitive endogenous RNA (ceRNA) regulatory network in POCD remains illiterate. Transcriptomic signatures in the hippocampus of POCD mice derived from the Gene Expression Omnibus (GEO) dataset GSE190880, GSE95070, and GSE115440 were used to identify the circRNA, miRNA, and mRNA expression profiles of POCD mice compared with controls, respectively. A set of differentially expressed RNAs, including 119 circRNAs, 33 miRNAs, and 49 mRNAs were identified. Transcript validation showed the enhanced expression of circ_0001634, circ_0001345, and circ_0001493. A ceRNA regulatory network composed of three circRNAs, three miRNAs, and six mRNAs was established. The hub mRNAs in the ceRNA network were further found to be involved in the hormone catabolic process and regulation of canonical Wnt signaling pathway, revealing their crucial role in POCD. Finally, three miRNAs and four mRNAs were verified by qRT-PCR. These results based on bioinformatics and PCR array suggest that circ_0001634/miR-490-5p/Rbm47, circ_0001634/miR-490-5p/Sostdc1, circ_0001634/miR-7001-5p/Sostdc1, circ_0001345/miR-7001-5p/Sostdc1, and circ_0001493/miR-7001-5p/Sostdc1 may be novel diagnostic biomarkers and therapeutic targets for POCD.

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Section: Discussionmentioning

confidence: 99%

Decoding competitive endogenous RNA regulatory network in postoperative cognitive dysfunction

et al. 2022

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“…Sostdc1 also increased the cell apoptotic rate and inhibited the proliferative ability in acute myeloid leukaemia (AML) by suppressing the Wnt/β-catenin pathway. Sostdc1 levels in the bone marrow of patients with AML were lower than those in healthy individuals, and patients with low levels of Sostdc1 had shorter survival times (Li et al, 2022). Furthermore, in the 5T2MM murine model of multiple myeloma (MM), Sostdc1 was shown to be expressed in low levels in MM and OB lineage cells while these cells were separately cultured, but its expression was substantially also induced in cell types when they were co-cultured, suggesting that the expression of Sostdc1 in 5TGM1-infiltrated bones could suppress osteoblast differentiation in bone and tumor microenvironment (Faraahi et al, 2019).…”

Section: Other Pathways That Regulate Cancermentioning

confidence: 92%

Role of Sostdc1 in skeletal biology and cancer

Tong

Zhu²,

Liu³

et al. 2022

Front. Physiol.

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Sclerostin domain-containing protein-1 (Sostdc1) is a member of the sclerostin family and encodes a secreted 28–32 kDa protein with a cystine knot-like domain and two N-linked glycosylation sites. Sostdc1 functions as an antagonist to bone morphogenetic protein (BMP), mediating BMP signaling. It also interacts with LRP6, mediating LRP6 and Wnt signaling, thus regulating cellular proliferation, differentiation, and programmed cell death. Sostdc1 plays various roles in the skin, intestines, brain, lungs, kidneys, and vasculature. Deletion of Sostdc1 gene in mice resulted in supernumerary teeth and improved the loss of renal function in Alport syndrome. In the skeletal system, Sostdc1 is essential for bone metabolism, bone density maintenance, and fracture healing. Recently, Sostdc1 has been found to be closely related to the development and progression of multiple cancer types, including breast, renal, gastric, and thyroid cancers. This article summarises the role of Sostdc1 in skeletal biology and related cancers to provide a theoretical basis for the treatment of related diseases.

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Decreasing of serine/threonine kinase 39 has tumour inhibiting effects on acute myeloid leukaemia by impacting the PI3K/AKT and Wnt/β-catenin signalling cascades

Li,

Xin,

Hao

et al. 2024

Toxicology and Applied Pharmacology

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SOSTDC1 acts as a tumor inhibitor in acute myeloid leukemia by downregulating the Wnt/β‐catenin pathway

Cited by 4 publications

References 41 publications

Decoding competitive endogenous RNA regulatory network in postoperative cognitive dysfunction

Decoding competitive endogenous RNA regulatory network in postoperative cognitive dysfunction

Role of Sostdc1 in skeletal biology and cancer

Decreasing of serine/threonine kinase 39 has tumour inhibiting effects on acute myeloid leukaemia by impacting the PI3K/AKT and Wnt/β-catenin signalling cascades

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