<scp>SOX</scp>‐10 expression in cutaneous myoepitheliomas and mixed tumors

Naujokas, Agne; Charli-Joseph, Yann; Ruben, Beth S.; Yeh, Iwei; LeBoit, Philip E.; McCalmont, Timothy H.; Pincus, Laura B.

doi:10.1111/cup.12279

Cited by 31 publications

(22 citation statements)

References 41 publications

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“…Sox-10 has recently been reported to be positive in some cases of cutaneous myoepithelioma (3 of 5 cases, 60%), however, it appears that these cases were of the classic variety rather than the syncytial variant of cutaneous myoepithelioma (16). Although no definitive conclusions could be drawn, in one of our cases where SOX-10 was performed, constituent cells were negative.…”

Section: Discussionmentioning

confidence: 94%

Cutaneous syncytial myoepithelioma: A recently described neoplasm which may mimic nevoid melanoma and epithelioid sarcoma

et al. 2017

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Cutaneous syncytial myoepithelioma is a recently described rare tumor of the dermis. It is derived and composed purely of myoepithelial cells and shows a characteristic syncytial growth pattern of neoplastic cells with little intervening stroma and no recognizable ductal structures. It represents a diagnostic challenge to dermatopathologists given its rarity and unusual immunophenotype. Molecular testing for rearrangement of the EWSR1 gene plays a significant role in confirming the diagnosis in most cases. Herein, we present 2 cases with mundane clinical presentations and challenging histopathological findings. In both cases, the lesion was composed of relatively well‐circumscribed proliferation of epithelioid and spindle cells in the superficial dermis growing in a syncytial fashion and showing focal adipocytic metaplasia. The 2 cases had slightly different immunohistochemical profiles, but shared focal positivity for S100, EMA and pan‐keratin or p63. Break‐apart FISH demonstrated the presence of an EWSR1 gene rearrangement confirming the diagnosis in both cases. We discuss the most important differential diagnoses, particularly melanocytic lesions and epithelioid sarcoma and the original diagnostic considerations that the cases were referred to us with. We also review the molecular features and spectrum of immunohistochemical findings in these lesions and their role in excluding entities in the differential diagnosis.

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Section: Discussionmentioning

confidence: 94%

Cutaneous syncytial myoepithelioma: A recently described neoplasm which may mimic nevoid melanoma and epithelioid sarcoma

et al. 2017

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“…Ohtomo et al [10] also demonstrated that, in the context of basaloid salivary gland neoplasms, the IHC profile of SOX10 differs from that of DOG1 only in that it is diffusely expressed in normal myoepithelial cells which are negative for DOG1. In addition to salivary gland myoepithelial lesions, SOX10 is also a reliable marker for cutaneous myoepitheliomas (60%) and cutaneous mixed tumors (100%) [21]. …”

Section: Discussionmentioning

confidence: 99%

Expression of SOX10 in Salivary Gland Oncocytic Neoplasms: A Review and a Comparative Analysis with Other Immunohistochemical Markers

Schmitt

Cohen

Siddiqui³

2015

Acta Cytologica

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Objectives: We evaluated SOX10 (SRY-related HMG-box 10) in differentiating acinic cell carcinoma (AciCC) from other salivary gland neoplasms with oncocytic features on fine-needle aspiration cell blocks (FNA CB) and compared its performance to DOG1 (discovered on gastrointestinal stromal tumor 1). Material and Methods: 35 FNA CB of oncocytic salivary gland neoplasms, i.e. 13 cases of AciCC, 16 of Warthin tumor (WT), 3 of mucoepidermoid carcinoma (MEC) and 3 of oncocytoma (ONC), and 75 salivary gland resections, i.e. 26 AciCC, 7 WT, 36 MEC, 3 ONC, 2 mammary analog secretory carcinomas (MASC) and 1 papillary cystadenoma were stained for SOX10 and DOG1. Results: None of the benign oncocytic neoplasms were immunoreactive for SOX10 on CB or resection, similar to DOG1. On CB, 61.5 and 77% of AciCC were positive for SOX10 and DOG1, respectively. All surgically resected AciCC cases were positive for SOX10 and DOG1; other malignant oncocytic lesions such as MEC and MASC demonstrated variable SOX10 and DOG1 staining. Conclusion: The use of SOX10 may increase the diagnostic accuracy of oncocytic lesions on FNA. In this context, SOX10 is equivalent to DOG1 in ruling out benign lesions such as WT and ONC; however, negative results for SOX10 as well as DOG1 do not favor a benign diagnosis since MEC is often negative for both markers.

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“…SOX10, a Schwannian and melanocytic marker also expressed in salivary gland myoepitheliomas, has also been shown to be useful as part of an immunohistochemical panel in distinguishing cutaneous myoepitheliomas. 27 CD34 and brachyury are consistently negative. 28 INI1 expression is lost in approximately 10% of adult soft-tissue myoepithelial carcinomas, [29][30][31] (Fig.…”

Section: Histopathologic and Immunohistochemical Findingsmentioning

confidence: 90%

Myoepithelial Tumor of Soft Tissue

Thway

Fisher

2014

Advances in Anatomic Pathology

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Myoepithelial neoplasms represent a heterogeneous group of tumors of which classification is incomplete and evolving. Those of the soft tissues often form genetically distinct subgroups that differ from those arising within salivary glands. Soft-tissue myoepithelial tumors (including mixed tumors that show true glandular or ductal differentiation) exhibit a spectrum of different morphologic patterns, making them difficult to distinguish from a variety of other neoplasms. They have been increasingly shown to harbor genetic fusions involving EWSR1 and partner genes that are not seen in the well-characterized tumor classes involving EWSR1 translocations. We review the spectrum of soft-tissue myoepithelial tumors, discussing recent immunohistochemical and genetic findings and the differential diagnosis.

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SOX‐10 expression in cutaneous myoepitheliomas and mixed tumors

Cited by 31 publications

References 41 publications

Cutaneous syncytial myoepithelioma: A recently described neoplasm which may mimic nevoid melanoma and epithelioid sarcoma

Cutaneous syncytial myoepithelioma: A recently described neoplasm which may mimic nevoid melanoma and epithelioid sarcoma

Expression of SOX10 in Salivary Gland Oncocytic Neoplasms: A Review and a Comparative Analysis with Other Immunohistochemical Markers

Myoepithelial Tumor of Soft Tissue

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