SPECT‐based functional lung imaging for the prediction of radiation pneumonitis: A clinical and dosimetric correlation

Abstract

SPECT-based DFH parameters appear to be useful as predictors of RP.

Inclusion of functional information from perfusion SPECT improves predictive value of dose–volume parameters in lung toxicity outcome after radiotherapy for non-small cell lung cancer: A prospective study

“…Marks et al [19] and Seppenwoolde et al [20] used SPECT-weighted parameters. Christian and co-workers [21] used mean perfusion-weighted lung dose, while Hoover et al [34] used normalised SPECT-weighted parameters. An alternative approach is segmentation of ''functional Abbreviations: NSCLC = non-small cell lung cancer; WHO = World Health Organisation; COPD = chronic obstructive pulmonary disease; GTV = gross tumour volume (t + n).…”

“…Data on the ability of SPECT parameters to predict pulmonary toxicity are sparse. Recent study by Hoover et al [34] has investigated the role of SPECT parameters in the development of RP in a small patient cohort. The authors found SPECT-parameters (functional MLD, V20 and V30) to be better predictors of RP.…”

“…A voxel by voxel comparison between the local SPECT intensity and the local dose was made. In this SPECT-weighted approach, a SPECT-scaled voxel volume was used instead of the physical voxel volume as previously described [34]. Weighting function W was used.…”

High-resolution pulmonary ventilation and perfusion PET/CT allows for functionally adapted intensity modulated radiotherapy in lung cancer

“…Complex inflammatory molecular responses to ionising radiation in these tissues result in both bronchoalveolar fibrosis and vascular endothelial effects, which can cause pulmonary ventilation and perfusion deficits [2]. Imaging modalities capable of assessing ventilatory function and blood perfusion have demonstrated that these deficits can be observed and are associated with the clinical risk of toxicity [3][4][5][6]. Planar scintigraphy using 99m Tc-labelled macroaggregated albumin (MAA) is a longestablished imaging standard for functional ventilation/perfusion evaluation.…”

Correlation of 68Ga Ventilation–Perfusion PET/CT with Pulmonary Function Test Indices for Assessing Lung Function

“…As an example, FEV1/FVC, which represents the volume of air expired in the first second expressed as a percentage of FVC, was compared with the percentage of the WL volume with normal perfusion and ventilation. In addition, PFTs are routinely interpreted as a multiparametric examination, and isolated values such as FEV1 or DLCO, although directly impaired by local therapies, have only limited significance (33,34). Nevertheless, a cutoff value of 90% for %NVQ correctly classified 100% of patients without pulmonary function impairment and 91% of patients with significant pulmonary function impairment, whatever the underlying pathology (COPD or severe DLCO impairment).…”