STRO‐1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis

Abstract

These findings suggested that the stemness marker STRO-1 may be a crucial factor in the pathogenesis of areca quid chewing-associated OSF.

Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

“…116 The increased conversion of fibroblasts into myofibroblasts and upregulated stemness are indicated by their increased contraction, migration, invasion and expression of α-SMA and the pro α-1 chain of type-1 collagen. 116 These MSCs can serve as a source of multipotent cells that can rapidly repopulate the wound in response to epithelial injury. 116 Ye et al 117 showed that growth-regulated oncogene-α (GRO-α) secretion by OSF fibroblasts promotes oral keratinocyte malignant transformation by augmenting EGFR/ERK signalling, F-actin rearrangement and stemness.…”

“…116 These MSCs can serve as a source of multipotent cells that can rapidly repopulate the wound in response to epithelial injury. 116 Ye et al 117 showed that growth-regulated oncogene-α (GRO-α) secretion by OSF fibroblasts promotes oral keratinocyte malignant transformation by augmenting EGFR/ERK signalling, F-actin rearrangement and stemness. Transformed keratinocytes can then acquire further genetic alterations with the evolution of more invasive clones.…”

“…Via TGF-β, arecoline drives the upregulation of the mesenchymal stem cell (MSC) marker STRO-1 in OSF. 116 The increased conversion of fibroblasts into myofibroblasts and upregulated stemness are indicated by their increased contraction, migration, invasion and expression of α-SMA and the pro α-1 chain of type-1 collagen. 116 These MSCs can serve as a source of multipotent cells that can rapidly repopulate the wound in response to epithelial injury.…”

“… 116 These MSCs can serve as a source of multipotent cells that can rapidly repopulate the wound in response to epithelial injury. 116 …”

Butylidenephthalide abrogates the myofibroblasts activation and mesenchymal transdifferentiation in oral submucous fibrosis

“…Despite the aetiology has not been well‐understood, the implication of areca nut chewing was observed in the development of OSF . A number of studies have demonstrated that areca nut upregulated various epithelial‐mesenchymal transition (EMT) and stemness factors, which may lead to myofibroblast transdifferentiation from human buccal mucosal fibroblasts (BMFs). It has been known that persistent activation of myofibroblasts resulted in excessive deposition of extracellular matrix (ECM), leading to pathological fibrosis.…”