<scp>
              <sup>99m</sup>
              Tc
            </scp>
            Radiopharmaceutical Chemistry

Papagiannopoulou, Dionysia

doi:10.1002/9781119500575.ch12

Cited by 2 publications

(1 citation statement)

References 324 publications

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“…Technetium-99m is a γ-emitting radioisotopes (E γ = 140 keV, 89%) with a moderate half-life of 6 h. The emission is well suited to be detected by medical equipment such as SPECT cameras. It has become the most used radionuclide in diagnostic nuclear medicine mainly because it can be readily produced by commercial 99 Mo/ 99m Tc generators [ 32 ]. Being a metal, technetium-99m can only be inserted in a biological molecule through a complexation reaction with proper chelators covalently linked to a molecular vector [ 33 , 34 ].…”

Section: Technetium-99m and Gallium-68 Labeled Chalcone Derivativesmentioning

confidence: 99%

Radiolabeled Chalcone Derivatives as Potential Radiotracers for β-Amyloid Plaques Imaging

et al. 2023

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Natural products often provide a pool of pharmacologically relevant precursors for the development of various drug-related molecules. In this review, the research performed on some radiolabeled chalcone derivatives characterized by the presence of the α-β unsaturated carbonyl functional group as potential radiotracers for the imaging of β-amyloids plaques will be summarized. Chalcones’ structural modifications and chemical approaches which allow their radiolabeling with the most common SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) radionuclides will be described, as well as the state of the art regarding their in vitro binding affinity and in vivo biodistribution and pharmacokinetics in preclinical studies. Moreover, an explanation of the rationale behind their potential utilization as probes for Alzheimer’s disease in nuclear medicine applications will be provided.

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Section: Technetium-99m and Gallium-68 Labeled Chalcone Derivativesmentioning

confidence: 99%