<scp>TNF</scp>‐α (−308G&gt;A) and <scp>TNF</scp>‐R1 (36A&gt;G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development

Ilić, Branislav; Nikolic, Nadja; Andrić, Miroslav; Jelovac, Drago; Miličić, Biljana; Jozić, Tanja; Krstić, S; Milašin, Jelena

doi:10.1111/jop.12564

Cited by 7 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Salles et al (2017) have reported the association between TNF‐α (−308 G >A) polymorphism and acute AP. The present results are also in line with previously conducted studies in Serbian populations regarding functional polymorphisms in TNF‐α gene and the risk of peri‐implantitis (Rakic et al 2015) and odontogenic keratocystic tumour (Ilic et al 2017) development, both suggesting that homozygous carriers of the variant A allele are significantly more prone to disease development.…”

Section: Discussionsupporting

confidence: 92%

Association of polymorphisms in TNF‐α, IL‐1β, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?

et al. 2020

Self Cite

View full text Add to dashboard Cite

Aim To investigate the possible association between TNFα (−308 G/A) and IL‐1β (−511 C/T) single nucleotide polymorphisms (SNPs) and GSTT and GSTM deletion polymorphisms and risk of apical periodontitis (AP) development, and determine the association of different genotypes with the presence of herpesviral infection in AP. Methodology The study included 120 periapical lesions and 200 control samples. Gene polymorphism analysis was performed using either polymerase chain reaction (PCR) or PCR/ restriction fragment length polymorphism (RFLP). Relative gene expression of TNF‐α and IL‐1β was analysed using reverse transcriptase – real‐time PCR. The presence of Epstein–Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by nested PCR. Chi‐square and Fisher’s exact tests and logistic regression analyses were done for polymorphisms, whilst Mann–Whitney U‐test was performed for the expression analysis. The expected frequency of variants was analysed by the Hardy–Weinberg equilibrium test. Results TNF‐α (−308 G/A) SNP increased AP susceptibility for heterozygous (odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.06–2.80, P = 0.027) and homozygous (OR = 8.55, 95% CI = 1.77–41.36, P < 0.001) carriers of the variant A allele. On the other hand, IL‐1β (−511 C/T) polymorphism exerted a protective effect both in heterozygotes (OR = 0.540, 95% CI = 0.332–0.880, P = 0.013) and homozygotes (OR = 0.114, 95% CI = 0.026–0.501, P < 0.001). In addition, GSTM1 and GSTT1 null genotypes separately, as well as concomitantly, were associated with an increased risk for AP development (P < 0.001). The null GSTT1 genotype increased approximately twice the risk of Epstein–Barr infection (EBV) in AP (OR = 2.17, 95% CI = 1–4.71, P = 0.048), whilst TNF‐α SNP decreased it, both in heterozygotes (OR = 0.20, 95% CI = 0.08–0.48, P < 0.001) and AA homozygotes (OR = 0.07, 95% CI = 0.01–0.37, P = 0.001). Conclusions GSTM and GSTT deletion polymorphisms, as well as TNFα (−308 G/A) SNP, are associated with increased risk, whereas IL‐1β (−511 C/T) polymorphism decreases the risk of AP development. GSTT and TNFα polymorphisms also appear to modulate the risk of EBV infection in Serbian patients with AP.

show abstract

Section: Discussionsupporting

confidence: 92%

Association of polymorphisms in TNF‐α, IL‐1β, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Maybe, the frequency difference between study populations with higher prevalence in Asian and American population may be explained by genetic susceptibility and polymorphism of some gene groups, as happens in odontogenic keratocystic tumour 67 and ameloblastoma; 68 however, no study evaluated this characteristic for OM.…”

Section: Discussionmentioning

confidence: 99%

Odontogenic Myxoma: Systematic review and bias analysis

Dotta

Miotto

Spin‐Neto

et al. 2020

Eur J Clin Investigation

View full text Add to dashboard Cite

Background Odontogenic myxoma (OM) is a rare neoplasm, which originates from odontogenic ectomesenchyme. There is no study in the literature that analyses the best standards for OM diagnosis and how the treatment modalities may influence the recurrence rates. Objective To evaluate the best standards for odontogenic myxoma (OM) diagnosis and treatment, and how these may influence the recurrence rates. Study design Two independent researchers performed a systematic review in many databases. Fifty‐two eligible studies were included for qualitative analysis. Bias analysis was conducted according to Oxford Centre for Evidence‐Based Medicine. Results A total of 1363 OM cases were reported on, and female gender with average age of 27 years is the most common patient profile. Conventional microscopic findings were observed in 93.43% of the reported cases. In 57.49% of the cases, multilocular radiographic appearance was present, followed by unilocular appearance (32.87%). Posterior mandible was the site with the major prevalence, while surgical resection was the most common treatment modality, followed by enucleation. Recurrence rates for both treatment modalities were approximately close (13.04% and 25.0%, respectively). Conclusion The correct diagnosis of OM relies on the association of clinical, radiographic and microscopic findings. About imaging examinations, panoramic radiography and computed tomography are sufficient for the evaluation of OM. Recurrence rates were closely among the two most used surgery treatments. So according to some clinical‐radiological aspects, conservative surgery may be preferred than aggressive surgery modalities.

show abstract

“…Another common subject of the investigation was genes related to proinflammatory cytokines and tissue degradation enzymes. Genes encoding interleukins IL‐1α, IL‐1β, and tumor necrosis factor TNF‐α and its receptor TNF‐R1 were analyzed in three studies (Eshghyar et al., 2012; Ilic et al., 2017; Sengüven & Oygür, 2011), and one study evaluated polymorphisms of matrix metalloproteinases MMP9 and MMP2 genes (Aloka et al., 2019).…”

Section: Resultsmentioning

confidence: 99%

Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review

et al. 2021

Self Cite

View full text Add to dashboard Cite

Objectives:The aim of this systematic review was to critically analyze available data on gene polymorphisms in odontogenic keratocysts (OKC) and ameloblastomas, including their possible relationship with clinical and histological features of these lesions. Materials and Methods: A comprehensive search of Web of Science Scopus, PubMed, Cochrane Central Register of Controlled Trials and EMBASE was conducted using relevant key terms and supplemented by a gray literature search. Quality assessment of included studies was performed using criteria from the Strengthening the Reporting of Genetic Association (STREGA) statement. Results: Ten studies were included in the final review. Survivin -31G/C, interleukin IL-1α -889 C/T, p53 codon 72 G/C, tumor necrosis factor TNFα (−308G>A) and itsreceptor TNF-R1 (36A>G), glioma-associated oncogene homolog 1 rs2228224 and matrix metalloproteinase 2 rs243865 gene polymorphisms were reported to be associated with OKC. For ameloblastomas, p53 codon 72 G/C, X-ray repair crosscomplementing protein 1-codons 194 and 399 and matrix metalloproteinase 9 rs3918242 gene polymorphisms were identified as risk factors. It was not possible to establish a relationship between specific polymorphisms and clinical and histological features of investigated lesions. Conclusions:Several gene polymorphisms might be considered as a risk factor for the development of these lesions. Future studies should investigate whether these polymorphisms might be used to identify patients with increased risk of recurrence or aggressive disease.

show abstract

TNF‐α (−308G>A) and TNF‐R1 (36A>G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development

Abstract: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.

Cited by 7 publications

References 29 publications

Association of polymorphisms in TNF‐α, IL‐1β, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?

Association of polymorphisms in TNF‐α, IL‐1β, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?

Odontogenic Myxoma: Systematic review and bias analysis

Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review

Contact Info

Product

Resources

About