2024
DOI: 10.1002/glia.24663
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WDR49‐Positive Astrocytes Mark Severity of Neurodegeneration in Frontotemporal Lobar Degeneration and Alzheimer's Disease

Ana Rajicic,
Lucia A. A. Giannini,
Emma Gerrits
et al.

Abstract: A subpopulation of astrocytes expressing WD Repeat Domain 49 (WDR49) was recently identified in frontotemporal lobar degeneration (FTLD) with GRN pathogenic variants. This is the first study to investigate their expression and relation to pathology in other FTLD subtypes and Alzheimer's disease (AD). In a postmortem cohort of TDP‐43 proteinopathies (12 GRN, 11 C9orf72, 9 sporadic TDP‐43), tauopathies (13 MAPT, 8 sporadic tau), 10 AD, and four controls, immunohistochemistry and immunofluorescence were performed… Show more

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