WITHDRAWN: Glucocorticoids ameliorate periostin‐induced tissue remodeling in chronic rhinosinusitis with nasal polyps

Abstract

We suggest that GCs are therapeutic agents for CRSwNP by inhibiting tissue remodeling through their inhibitory effect on Src/Akt/mTOR signaling pathway. This article is protected by copyright. All rights reserved.

<p>Confounding Patient Factors Affecting the Proper Interpretation of the Periostin Level as a Biomarker in Asthma Development</p>

“…34 Moreover, Flovent was shown to inhibit POSTN production and its activation of Src/AKT/ mTOR pathway. 35 Therefore, this finding confirmed that POSTN expression can be used to monitor the response or patient compliance with Flovent treatment. On the other hand, the use of Symbicort correlated positively with the plasma level of POSTN ( Figure 5).…”

Role of periostin in ECRS

“…In support of this change, through experimentation, Yang et al found that periostin could induce activation of the Src/AKT/ mTOR signaling pathway, resulting in tissue remodeling by differentiation of fibroblasts into myofibroblasts and expression of extracellular matrix components. Glucocorticoids ameliorate periostin-induced tissue remodeling in chronic rhinosinusitis with nasal polyps [49]. Vascular endothelial growth factor(VEGF), as a key role in regulating of remodeling in ECRS, mainly consisting of tissue remodeling and an edematous nasal mucosa could be promoted by periostin through the focal adhesion kinase(FAK) or signal-regulated kinase 1/2(ERK1/2) signaling pathways [50].…”

“…In treatment for ECRS, glucocorticoids (GCs) treatment including dexamethasone or tomography could suppressed periostin-caused effects [49]. In supporting of this, researches applied GCs as therapeutic agents into CRSwNP patients and achieved better outcomes through inhibiting tissue remodeling [64].…”

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

“…Periostin promotes adhesion and migration of epithelial cells and is associated with CRSwNP (Ishida et al, 2012;Ohta et al, 2014;Laury et al, 2015;Milonski et al, 2015;Shiono et al, 2015;Wang et al, 2015;Ebenezer et al, 2017;Xu et al, 2017;Wei et al, 2018;Yang et al, 2018;Lehmann et al, 2019) and asthma (Carpagnano et al, 2018;Wei et al, 2018). The EMT process is driven by an array of factors such as WNT, reactive oxygen species, proteases, HIF1, IL-13 Epiregulin, Oncostatin M, and IL-1 (Oyer et al, 2013;Batzakakis et al, 2014;Schleimer, 2017;Aazami et al, 2018;Yang et al, 2018;Tomaszewska et al, 2019).…”

“…Periostin promotes adhesion and migration of epithelial cells and is associated with CRSwNP (Ishida et al, 2012;Ohta et al, 2014;Laury et al, 2015;Milonski et al, 2015;Shiono et al, 2015;Wang et al, 2015;Ebenezer et al, 2017;Xu et al, 2017;Wei et al, 2018;Yang et al, 2018;Lehmann et al, 2019) and asthma (Carpagnano et al, 2018;Wei et al, 2018). The EMT process is driven by an array of factors such as WNT, reactive oxygen species, proteases, HIF1, IL-13 Epiregulin, Oncostatin M, and IL-1 (Oyer et al, 2013;Batzakakis et al, 2014;Schleimer, 2017;Aazami et al, 2018;Yang et al, 2018;Tomaszewska et al, 2019). CRSwNP patients have altered expression levels of EMT related factors, such as MMP-1 (Malinsky et al, 2013;Homma et al, 2017), MMP-2 (Malinsky et al, 2013), TIMP-1 (Wang et al, 2012;Muluk et al, 2015), MMP-7 (Yang et al, 2017;Chen et al, 2018), MMP-9 (Wang et al, 2012;Malinsky et al, 2013;Yeo et al, 2013;Li et al, 2015;Muluk et al, 2015;Chen et al, 2018;Suzuki et al, 2018;Xiang et al, 2019), TIMP-2 (Li et al, 2015) E-cadherin (Hupin et al, 2014;Kim et al, 2018;…”