Screen-detected versus interval cancers: Effect of imaging modality and breast density in the Flemish Breast Cancer Screening Programme

Timmermans, L.; Bleyen, Luc; Bacher, Klaus; Herck, Koen Van; Lemmens, Kim; Ongeval, Chantal Van; Steen, Andreas Van; Martens, Patrick; Brabander, Isabel De; Goossens, Herman; Thierens, Hubert

doi:10.1007/s00330-017-4757-4

Cited by 18 publications

(13 citation statements)

References 45 publications

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“…In this cohort, breast imaging was not performed routinely before surgery. In Belgium, biannual mammography is standard breast cancer screening for women aged 50–69 years, and transmen in this age group often participate in the screening programme. Screening mammography identified one invasive cancer in a 52‐year‐old transman.…”

Section: Discussionmentioning

confidence: 99%

Routine histopathological examination after female-to-male gender-confirming mastectomy

Renterghem

Dorpe

Monstrey

et al. 2018

British Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Routine histopathological examination after female-to-male gender-confirming mastectomy

Renterghem

Dorpe

Monstrey

et al. 2018

British Journal of Surgery

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“…Increased breast density may also convey an increased intrinsic risk of developing cancer. In the findings from multiple studies, investigators have demonstrated that higher levels of mammographic density are associated with a greater likelihood of cancers and also interval cancers (2,3), with an odds ratio (OR) of 4.7 (95% confidence interval [CI]: 3.0, 7.4) reported in women with extremely dense breasts, compared with women with predominantly fatty tissue, in screening and nonscreening cases combined (4,5).…”

Section: Breast Densitymentioning

confidence: 99%

Hormonal Effects on Breast Density, Fibroglandular Tissue, and Background Parenchymal Enhancement

et al. 2018

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Breast density, fibroglandular tissue, and background parenchymal enhancement (BPE) are recognized independent biomarkers for breast cancer risk. For this reason, reproducibility and consistency in objective assessment of these parameters at mammography (breast density) and at magnetic resonance imaging (fibroglandular tissue and BPE) are clinically relevant. However, breast density, fibroglandular tissue, and BPE are manifestations of dynamic physiologic processes and may change in response to both endogenous and exogenous hormonal stimulation. It is therefore important for the radiologist to recognize settings in which hormonal stimulation may alter the appearance of these biomarkers at imaging and to appreciate how such changes may affect risk assessment, cancer detection, and even prognosis. The purpose of this review article is therefore to review key features and means of evaluating breast density, fibroglandular tissue, and BPE at imaging; to detail how endogenous and exogenous hormonal stimuli may affect breast density, fibroglandular tissue, and BPE, potentially affecting radiologic interpretation; and, finally, to provide an update regarding current hormone treatment guidelines and indications that may result in imaging changes through hormone modulation. RSNA, 2018.

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“…In several studies, DR detector systems seem to be superior to CR detector systems, also in clinical screening performance. Often higher sensitivity is found with higher cancer detection rates and less interval cancers, especially in dense breasts [2,10,11]. Since this review was performed by a single -albeit highly experienced -radiologist, the results of this retrospective review could not be corrected for interobserver variability.…”

Section: The Proportion Of Cases With 'Clearly Visible Tumours'mentioning

confidence: 99%

“…Breast cancer screening programmes have substantially increased the number of early detected cancers [ 1 ]. However, studies have made clear that current screening programmes only capture about 70% of all breast cancers that occur in participating women [ 2 3 4 ].…”

Section: Introductionmentioning

confidence: 99%

In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer

Vandendaele

Jidkova

Herck

et al. 2022

Journal of the Belgian Society of Radiology

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Objectives:We aim to contribute to the assessment of the screening performance in Flanders (Belgium) and to identify valuable mammograms for subsequent studies and training. Materials and Methods:Initially negative prior screening mammograms (sMx) of 210 women with confirmed breast cancer detected by the Flemish screening programme between 2011-2013 were reviewed by a highly experienced radiologist. The review of the prior sMx was performed in three steps: 1) only prior mammograms available; 2) with index sMx (=subsequent positive sMx) present; 3) with index sMx and clinical information present. Results:The radiological review yielded 94 (45%) mammograms 'without suspicious lesions', 77 (37%) 'with minimal signs in at least one breast', and 39 (19%) 'with clearly visible tumours'. In univariate analyses, the reclassification of prior sMx was significantly associated with the date of the prior sMx, the need for a third reader for arbitration, image quality and the detector system used (computed radiography versus direct readout digital radiography), and it was not associated with the interval between screening rounds, age at prior sMx, breast density, or tumour characteristics (

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Screen-detected versus interval cancers: Effect of imaging modality and breast density in the Flemish Breast Cancer Screening Programme

Cited by 18 publications

References 45 publications

Routine histopathological examination after female-to-male gender-confirming mastectomy

Routine histopathological examination after female-to-male gender-confirming mastectomy

Hormonal Effects on Breast Density, Fibroglandular Tissue, and Background Parenchymal Enhancement

In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer

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