Screen-printed organic electrochemical transistors for metabolite sensing

Scheiblin, Gaëtan; Aliane, A.; Strakosas, Xenofon; Curto, Vincenzo F.; Coppard, R.; Marchand, Gilles; Owens, Róisı́n M.; Mailley, Pascal; Malliaras, George G.

doi:10.1557/mrc.2015.52

Cited by 53 publications

(49 citation statements)

References 25 publications

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“…Screen-printing has also been successfully used for the fabrication of OECTs-based biosensors. In 2015, Scheiblin et al [111] reported on the fabrication of glucose and lactate sensors on a flexible, plastic substrate (polyethylene naphthalate, PEN). These devices were obtained by using three different inks: PEDOT:PSS (fabrication of the transistors active channel, final thickness of 500 nm), poly(vinylidene fluoride) (PVDF, a dielectric material used to insulate the electrical contacts and define the contact area between the channel and the electrolyte, final thickness of 2 µm) and finally a silver-based ink (used to realize the electrical contacts, final thickness of approximately 8 µm).…”

Section: Screen-printingmentioning

confidence: 99%

“…If the previous example used GOx in solution, in almost all recent publications, GOx was immobilized within the device structure, preventing enzyme leakage and decrease of signal over time. For example, Malliaras and coworkers developed a screen-printed OECT for both glucose and lactate sensing [111]. Rather than being present in solution, both the ferrocene mediator, which was covalently bound to chitosan, and the GOx were integrated into the sol-gel electrolyte which prevented their further deterioration during measurements.…”

Section: Glucosementioning

confidence: 99%

“…Scheiblin et al [111] reported screen-printed biosensors on a flexible PEN substrate for glucose and lactate sensing in human sweat. The detection range of the printed sensors extended from 0.1 to 2.3 mM, i.e., the low end of the level range of lactate in sweat, the high end of the range only being accessible by dilution.…”

Section: Lactatementioning

confidence: 99%

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Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

et al. 2018

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Featured Application: Sensing organic molecules in water.Abstract: This review first recalls the basic functioning principles of organic electrochemical transistors (OECTs) then focuses on the transduction mechanisms applicable to OECTs. Materials constituting the active semiconducting part are reviewed, from the historical conducting polymers (polyaniline, polypyrrole) to the actual gold standard, poly-3,4-ethylenedioxythiophene: polystyrene sulfonic acid (PEDOT:PSS), as well as the methods used to fabricate these transistors. The review then focuses on applications of OECTs for the detection of small molecules and more particularly of metabolites, with a distinction between enzymatic and non-enzymatic transduction pathways. Finally, the few patents registered on the topic of OECT-based biosensors are reviewed, and new tracks of improvement are proposed. applied to biosensing quite early, associated with enzymes [4][5][6]. This is because, due to their functioning mechanism (already identified at the time), they brought into play the same charge carriers as most biological functions, i.e., electrons but also ions, and were therefore sensitive both to electron transfer to/from redox enzymes or ions (e.g., protons) produced from other types of enzymes. This is a characteristic which distinguished them from organic field-effect transistors (OFETs), which started to raise the attention of researchers exactly at the same period (precisely, 1983 for the first polyacetylene-based OFET [7]), and a few years later for applications to gas sensing (halogens, ammonia, oxygen [8-10] or even vapors of H 2 O, NO or H 2 O 2 [11][12][13][14]). However, OFETs never really produced any applicable results in the framework of biosensors in aqueous environment because of high operating voltages, of several tens of volts, which impede any measurements because of water electrolysis. Ion-sensitive organic field-effect transistors (ISOFETs), based on the same working principles of their inorganic counterparts (ISFETs) developed earlier [15,16], solved this problem of high operating potential, the electrolyte being not in direct contact with the semiconductor. However, these devices were confined mostly to protons detection [17][18][19] or, in any case, to charged species.As we show in this review, OECTs use both potentiometry and amperometry in their working principles. In that sense, OECTs are devices that represent a bridge between ISOFETs and classical amperometry, which certainly explains their success. This area of research is very active and several reviews have already been published on OECTs in general, for example by Kergoat et al. [1] or Rivnay et al. [3], or on OECTs applied to biology, for example by Liao and Yan [20], Liao et al. [21], Strakosas et al. [22] or . This present review, after going back to the basic functioning principles, along with details on transductions applicable to OECTs, reviews materials, fabrication techniques and then sensing applications. We focus on the detection of small molecules and more part...

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Section: Screen-printingmentioning

confidence: 99%

Section: Glucosementioning

confidence: 99%

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Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

et al. 2018

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“…[1][2][3][4] Of the many electronic devices utilizing organic semiconductors, organic thin-film transistors (OTFTs) have in recent years become important components of large-area flexible displays as well as of radio-frequency identification tags, logic circuits, smart cards, and chemical sensors. [1][2][3][4] Of the many electronic devices utilizing organic semiconductors, organic thin-film transistors (OTFTs) have in recent years become important components of large-area flexible displays as well as of radio-frequency identification tags, logic circuits, smart cards, and chemical sensors.…”

Section: Introductionmentioning

confidence: 99%

Spin Self‐Assembled Clay Nanocomposite Passivation Layers Made from a Photocrosslinkable Poly(vinyl alcohol) and Na⁺‐Montmorillonite Enhance the Environmental Stability of Organic Thin‐Film Transistors

et al. 2016

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We investigated the effects of the multilayer polymer-clay nanohybrid passivation films on the stability of pentacene organic thin-film transistors (OTFTs) exposed to air and UV irradiation. Well-ordered multilayer films were deposited by the spin-assisted layer-by-layer assembly method using photocrosslinkable poly(vinyl alcohol) with the N-methyl-4(4'-formylstyryl)pyridinium methosulfate acetal group (SbQ-PVA) and Na ＋ -montmorillonite in a water-based solution process. When photocrosslinked, these SbQ-PVA/clay multilayers were found to serve as excellent barriers to O 2 and UV-light. Moreover, when used as passivation layers, they enhanced the stability of pentacene OTFT devices exposed to air and UV radiation. Figure 5 Time dependence of the electrical characteristics of pentacene FETs in RH 70%: (a) relative mobility, (b) on current, (c) transfer performance of unpassivated device, (d) transfer performance of device passivated with the (SbQ-PVA/clay) 100 multilayer.

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“…Due to easy fabrication and CPs processability, OECTs found application in printed electronics, for the production of displays and biosensors. [29][30][31][32] Additionally, low operating voltages, stability in aqueous environment, and capability of interfacing ionic and electronic signals make them suitable devices for bioelectronics and healthcare applications. 33,34 However, despite their great success, OECTs currently suffer of many drawbacks, which limit their use for practical applications.…”

Section: Chapter 3 Electrochemical Transistorsmentioning

confidence: 99%

Self-doped Conjugated Polyelectrolytes for Bioelectronics Applications

Zeglio¹

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Self-doped conjugated polyelectrolytes (CPEs) are a class of conducting polymers constituted of a π-conjugated backbone and charged side groups. The ionic groups provide the counterions needed to balance the charged species formed in the CPEs backbones upon oxidation. As a result, addition of external counterions is not required, and the CPEs can be defined as selfdoped. The combination of their unique optical and electrical properties render them the perfect candidates for optoelectronic applications. Additionally, their “soft” nature provide for the mechanical compatibility necessary to interface with biological systems, rendering them promising materials for bioelectronics applications. CPEs solubility, aggregation state, and optoelectronic properties can be easily tuned by different means, such as blending or interaction with oppositely charged species (such as surfactants), in order to produce materials with the desired properties. In this thesis both the strategies have been explored to produce new functional materials that can be deposited to form a thin film and, therefore, used as an active layer in organic electrochemical transistors (OECTs). Microstructure formation of the films as well as influence on devices operation and performance have been investigated. We also show that these methods can be exploited to produce materials whose uniquecombination of self-doping ability and hydrophobicity allows incorporation into the phospholipid double layer of biomembranes, while retaining their properties. As a result, self-doped CPEs can be used both as sensing elements to probe the physical state of biomembranes, and as functional ones providing them with new functionalities, such as electrical conductivity. Integration of conductive electronic biomembranes into OECTs devices has brought us one step forward on the interface of manmade technologies with biological systems

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Screen-printed organic electrochemical transistors for metabolite sensing

Abstract: Abstract

Cited by 53 publications

References 25 publications

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

Spin Self‐Assembled Clay Nanocomposite Passivation Layers Made from a Photocrosslinkable Poly(vinyl alcohol) and Na⁺‐Montmorillonite Enhance the Environmental Stability of Organic Thin‐Film Transistors

Self-doped Conjugated Polyelectrolytes for Bioelectronics Applications

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Screen-printed organic electrochemical transistors for metabolite sensing

Abstract: Abstract

Cited by 53 publications

References 25 publications

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

Spin Self‐Assembled Clay Nanocomposite Passivation Layers Made from a Photocrosslinkable Poly(vinyl alcohol) and Na+‐Montmorillonite Enhance the Environmental Stability of Organic Thin‐Film Transistors

Self-doped Conjugated Polyelectrolytes for Bioelectronics Applications

Contact Info

Product

Resources

About

Spin Self‐Assembled Clay Nanocomposite Passivation Layers Made from a Photocrosslinkable Poly(vinyl alcohol) and Na⁺‐Montmorillonite Enhance the Environmental Stability of Organic Thin‐Film Transistors