Screening and Assessment of Polyneuropathy in Diabetic Patients and the Effect of Vitamin B12 Administration on the Course of Neuropathy

Chauhan, Alpesh; Patil, Ashwini; Bhosale, Uma A; Bhat, Shreepad

doi:10.7860/jcdr/2018/36126.11943

Cited by 2 publications

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“…On the other hand, oral methylcobalamin supplementation demonstrated beneficial effects on somatosensory symptoms, such as pain and paresthesias, in addition to improving the clinical parameters of the tests used to evaluate PN, without adverse effects associated with supplementation [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…In the present review, most studies highlight the role of vitamin B12 in the treatment or prevention of PN, particularly in patients with diabetes treated with metformin. Oral vitamin B12 supplementation therapy is advised in patients being treated with the hypoglycemic agent, justifying that it preserves the patient's autonomy, has a reduced cost and is lower risk to patients using anticoagulants [6,[9][10][11]14,19,22,23].…”

Section: Discussionmentioning

confidence: 99%

“…In the databases used in this review and within the inclusion and exclusion criteria, only two studies were found that performed vitamin B12 supplementation in patients with PN [22,23]. Both studies showed significant improvement in PN symptoms (Table 2).…”

Section: Relationship Between Vitamin B12 Supplementation and Periphe...mentioning

confidence: 99%

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Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review

Dias¹,

Pereira²,

Orrico³

2023

Braz. J. Hea. Rev.

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Background/Purpose: Type 2 diabetes mellitus (T2DM) is a worldwide pathology with several complications, and 50% of patients with T2DM develop peripheral neuropathy (PN) in the long term. The present study aimed to review the literature on the association between PN and vitamin B12 deficiency in patients with T2DM treated with metformin. Materials and methods: A literature review was carried out in the PubMed Central, Cochrane, Scielo, Scopus and Embase databases, from 2015 to 2021. We found 755 studies, of which 16 were included. Results: The serum level of vitamin B12 was lower in individuals with at least one neurological symptom. Treatment with metformin was associated with reduced serum vitamin B12 levels, and its use was defined as a probable cause of PN due to reduced vitamin B12. Studies that performed supplementation with methylcobalamin demonstrated significant improvement in neuropathic symptoms. Vitamin B12 supplementation therapy for diabetic patients undergoing metformin treatment has been suggested. Conclusion: Deficiency of vitamin B12 associated to metformin can be considered a risk factor for PN. Periodically evaluation of serum levels of vitamin B12 is recommended for patients on metformin treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review

Dias¹,

Pereira²,

Orrico³

2023

Braz. J. Hea. Rev.

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“…Так, в исследовании участвовали 50 чел., которые принимали метилкобаламин по 1,5 мг ежедневно в течение 3 мес. По истечении данного срока был выявлен значимый регресс невротической симптоматики и автономной дисфункции [45]. Описан клинический случай пациентки с СД 2-го типа и смешанной ПНП (ДПН и В 12 -дефицитарной), у которой наблюдался регресс симптомов на фоне приема препарата Нейробион [46].…”

Section: лечение полиневропатийunclassified

Difficult patient with polyneuropathy: CIDP associated with type 1 diabetes mellitus

et al. 2023

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Polyneuropathies are a heterogeneous group of diseases that can be caused both by a primary lesion of peripheral nerves, and secondarily, against the background of various somatic diseases. The most common cause of chronic polyneuropathy is distal symmetrical diabetic polyneuropathy. In clinical practice, it is important to be aware of dysimmune polyneuropathy, such as Guillain Barré syndrome, chronic inflammatory demyelinating polyneuropathy, and paraproteinemic polyneuropathy, which lead to severe motor impairment and disability in patients. Identification of the cause of polyneuropathy requires real art, which includes knowledge of the clinical, electrophysiological picture and variants of the course of the disease, as well as a wide range of conditions leading to their development. Timely diagnosis of polyneuropathies and early assignment of etiological and pathogenetic therapy reduce the risk of developing irreversible changes in peripheral nerves caused by axonal degeneration. In the treatment of polyneuropathy of various origins, a special place is occupied by B vitamins, which have a neurotropic effect. Cyanocobalamin is a pathogenetic therapy in patients with diabetes who take metformin for a long time and who developed polyneuropathy due to vitamin B12 deficiency. In one patient, a combination of several variants of polyneuropathies is possible. The article presents a clinical case of a patient with type 1 diabetes mellitus (DM) who developed dysimmune chronic inflammatory demyelinating polyneuropathy (CIDP) associated with DM on the background of distal symmetrical painless diabetic polyneuropathy after a COVID- 19 infection. A feature of the development of CIDP was the acute onset of the disease. Variants of the clinical picture, ENMG criteria, as well as features of treatment, the effectiveness of therapy and the prognosis of CIDP in patients with DM are discussed.

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Screening and Assessment of Polyneuropathy in Diabetic Patients and the Effect of Vitamin B12 Administration on the Course of Neuropathy

Cited by 2 publications

References 0 publications

Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review

Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review

Difficult patient with polyneuropathy: CIDP associated with type 1 diabetes mellitus

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