Screening and characterization of antioxidant, anti-aging, and anti-microbial activity of herbal extracts in Northern Thailand

Khonthun, Chakkraphong; Khoothiam, Krissana; Chumphukam, Orada; Thongboontho, Rungthip; Oonlao, Panida; Nuntaboon, Piyawan; Phromnoi, Kanokkarn

doi:10.31989/ffhd.v13i2.1070

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…In recent years, microorganisms have become resistant to antibiotics, and the inadequacy of synthetic drugs has increased the interest in natural-origin drugs (12,13). Scientists have proven the medicinal effect of plant-based products on microorganisms (14,15). Food poisoning caused by pathogenic microorganisms in food poses an important health problem worldwide.…”

Section: Introductionmentioning

confidence: 99%

A Natural Additive Alternative to the Cosmetics Industry: Hazelnut and Its Waste Products

Sağlam

ÖZÜSAĞLAM

2023

J Skin Stem Cell

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Background: Today, individuals tend to use natural products instead of synthetic additives in many areas. The hazelnut tree produces many by-products and fruit. Nuts and their by-products are rich in bioactive compounds. Objectives: This study investigated the biological activities of water and ethanol extracts obtained from hazelnut and its waste products to determine their potential usage in the cosmetic industry. Methods: In this experimental study, disc diffusion test, minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), or minimum fungicidal concentration (MFC) were applied to evaluate the antimicrobial potential of the extracts. The sun protection factor (SPF) of the extracts and commercial cream + extract mixtures was determined in vitro. In addition, antimicrobial cream formulations containing hazelnut extracts and Limosilactobacillus fermentum MA-7 probiotic candidate lactic acid bacteria from human milk were developed for the pharmaceutical industry to prevent infections. The good diffusion test was applied against test microorganisms to evaluate antimicrobial activity. Results: The hazelnut husk methanol extract had the highest inhibition zone diameter (19.41 mm) against Yersinia ruckeri. The MIC, MBC, or MFC of the extracts ranged from 1.25 to > 40 µg/µL. The SPF values of the extracts (range: 6.85-27.64) and commercial cream + extract (range: 11.92-26.28) mixtures were determined in vitro to obtain their potential use in sunscreens. The cream groups containing hazelnut extracts and probiotics showed a high antimicrobial effect on the tested microorganisms. The results of statistical analysis indicated that the cream + extract + probiotic pellet + probiotic supernatant group was statistically significant (P < 0.05) compared to other test groups. Conclusions: The results showed that hazelnuts and their by-products have the potential to be used as a natural source of antimicrobials. Hazelnut and its by-products can be an alternative to synthetic antimicrobials and sunscreens in the cosmetic industry as a natural bioactive substance. In addition, it might contribute to the country’s economy by evaluating hazelnuts and their waste and by-products resulting from their processing in the cosmetic industry.

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Section: Introductionmentioning

confidence: 99%

A Natural Additive Alternative to the Cosmetics Industry: Hazelnut and Its Waste Products

Sağlam

ÖZÜSAĞLAM

2023

J Skin Stem Cell

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“…Bioflavonoids and various secondary metabolites in plant extract have antioxidant, anti-inflammatory activity and restrain aging of body cells and tissues[34][35][36]. The food supplement IQdetoxSORB is advertised as a sorptiondetoxification agent of the organism's internal environment[37].…”

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confidence: 99%

Phytomineral complexes as elements of functional nutrition to enhance the protective function of the lymphatic system in aging

Gorchakov,

Nicolaychuk,

Gorchakova

et al. 2024

BCHD

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Background: The problem of aging remains relevant in the modern world, with a notable connection between aging and nutrition. It is important to find a way to slow down aging. Integration lymphology with functional food theory (or phytodietics) is the most promising idea. Detection of lymphotropic properties in bioactive food ingredients will increase the lymphatic system activity in aging. Our task is to improve the protective status of lymph nodes by taking a phytomineral product in aging. Objective: The research purpose is to provide evidence of the use of a plant-mineral complex to activate the lymph system (lymph nodes) in aging. Participants in the experiment are 160 Wistar rats divided into groups of old and young animals. Half of the aging animals took an additional food plant-mineral complex "IQdetoxSORB". The basis of the food complex is physiologically acting substances such as flavonoids, trace elements, food fibers, and others.Methods: Different methods have been applied to study systems forming components of lymph nodes. The system of lymph node compartments was examined by a histological method. The liquid component of the organ is evaluated by a thermogravimetric method. Lymph node trace elements (Mn, Fe, Cu, Zn, Se) were determined by X-ray fluorescence analysis using synchrotron radiation (RFA SR). The StatPlus Pro license program and statistical analysis of dynamic series were used to process digital data.Results: We first presented data on the effect of functional nutrition on the lymphatic system and proved the lymphotropic properties of the plant-mineral complex. The bioactive ingredients of the complex (flavonoids, trace elements, food fibers) are useful and influence the lymphatic system, improving health in old age. The increase in lymphatic system activity occurs through the implementation of a lymphosanation mechanism due to the stimulating and protective effects of plant ingredients. Intake of the phytomineral complex accelerates lymph flow, modifies lymph node compartments, and restores trace element balance. The positive effect depends on the formation of an association of bioelements with lymphoid compartments. A plant-based diet corrects and increases the protective status of lymph nodes. The result is a slowdown in age-induced changes in peripheral lymphoid organs. Conclusion: As an element of functional nutrition, the plant-mineral complex contains bioactive ingredients - flavonoids, trace elements, and food fibers. These bioactive substances alter the existing status of the lymphatic system, increasing protective potential. Increased activity of the lymph system (lymph nodes) is an argument for slowing aging and preventing age-associated pathology. The information presented is the basis for recommending plant-mineral complexes for wellness programs of anti-aging.Keywords:lymphatic system; lymph nodes; compartments; trace elements; gerontology, phytotherapy, nutriciology.

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“…The antioxidant capacity of coriander root seemed to correlate with TFC and TPC. Several studies demonstrated a strong correlation between antioxidant capacity by both assays and the TFC and TPC values[15,[26][27][28]. However, it is worth noticing that boiling extract, which contained the lowest TFC and TPC, exhibited ABTS radical scavenging capacity comparable to 100% ethanol extract.…”

mentioning

confidence: 99%

In vitro antioxidant and alpha-glucosidase inhibitory activities of coriander (Coriandrum sativum L.) root extracts

Choochuntra,

Nutmakul,

Chewchinda

et al. 2024

FFHD

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Background: Coriander (Coriandrum sativum L.) is a versatile culinary herb known for its edible leaves, seeds, stems, and roots. It is widely utilized in traditional medicine across the globe and is reputed for its diverse biological properties, including significant antioxidant and antidiabetic effects. Nonetheless, the majority of research has primarily concentrated on the seeds, leaves, and stems, leaving the roots comparatively underexplored. Objective: This research delved into the antioxidative capabilities and alpha-glucosidase inhibitory properties of coriander root extracts and assessed their phytochemical makeup. Methods: The coriander roots were lyophilized, pulverized to powder, and extracted using two methods: boiling and maceration with water, 50% ethanol, or 100% ethanol. The extracts underwent assessment for antioxidant activity through ABTS and DPPH radical scavenging methods, total phenolic and flavonoid concentrations, and inhibition of the alpha-glucosidase enzyme. In addition, their phytochemical profiles were identified and quantified by HPLC. Results: Among all the extracts, the 100% ethanol extract demonstrated the greatest levels of total flavonoids and phenolics, exhibited the strongest antioxidant activity against ABTS and DPPH radicals, and showed the most potent alpha-glucosidase inhibition. Notably, the boiling extract, although containing the lowest total phenolic and flavonoid contents, exhibited ABTS radical scavenging capacity comparable to the 100% ethanol extract. This suggested that the boiling extract might contain non-phenolic antioxidant compounds and should be further studied. Additionally, HPLC analysis unveiled the novel identification of benzoic acid and ferulic acid within the coriander root extracts for the first time. The highest contents of these compounds were also found in the 100% ethanol extract. Conclusion: Coriander roots, a common culinary ingredient, exhibited antioxidant and alpha-glucosidase inhibitory activities, suggesting potential as a functional food for preventing age- and lifestyle-related diseases, such as diabetes and certain cancers. Keywords: Coriander roots, Antioxidants, Antidiabetics, Benzoic acid, Ferulic acid, HPLC analysis

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Screening and characterization of antioxidant, anti-aging, and anti-microbial activity of herbal extracts in Northern Thailand

Cited by 4 publications

References 41 publications

A Natural Additive Alternative to the Cosmetics Industry: Hazelnut and Its Waste Products

A Natural Additive Alternative to the Cosmetics Industry: Hazelnut and Its Waste Products

Phytomineral complexes as elements of functional nutrition to enhance the protective function of the lymphatic system in aging

In vitro antioxidant and alpha-glucosidase inhibitory activities of coriander (Coriandrum sativum L.) root extracts

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