Screening and evaluation of antioxidant activity of some pyridazine derivatives

Abstract

Antioxidants are compounds that can delay, inhibit, or prevent the oxidation of materials that can be oxidized by scavenging free radicals and help in diminishing oxidative stress. They belong to different chemical classes. Recently there are studies related to pyridazinone derivatives for their antioxidant activities. Since there are evidences implicates reactive oxygen species and nitric oxide as mediators of inflammation and/or tissue damage in inflammatory and arthritic disorders it was though that compounds that have both antioxidant and anti-inflammatory activities would have been essential for the inflammatory diseases. Based on these findings a series of 2H-pyridazine-3-one and 6-chloropyridazine analogues that have antiinflammatory activity was tested in vitro on superoxide formation and effects on lipid peroxidation were determined against atocopherol. Most of the compounds have strong inhibitory effect on superoxide anion (between 84% -99%) at 10 23 M concentration. In addition, these compounds showed similar activity to a-tocopherol at 10 23 M concentrations.

Design, synthesis, molecular docking and biological evaluation of imides, pyridazines, and imidazoles derived from itaconic anhydride for potential antioxidant and antimicrobial activities

“…Of the tested compounds, 1 mg/mL 5-methylidene-1-phenyltetrahydropyridazine-3,6-dione (5a) showed a better radical scavenging capacity than the standard glutathione. This enhanced activity could be due to the presence of acidic protons in its pyridazine moiety [21]. The compounds 3a, 6a, and 8a also showed moderate activity due to the presence of imide, pyridazine and imidazole functionalities in these molecules.…”

“…Of the tested compounds, 5-methylidene-1-phenyltetrahydropyridazine-3,6-dione (5a), 2-methylidene-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-1-one (8a) and 2-methylidene-7-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-1-one (8b) showed good NO scavenging ability at a concentration of 1 mg/mL in comparison with the standard glutathione. Such enhanced activity could be due to the presence of a pyridazine and imidazole moiety [21,25]. Compounds 3b, 3c, 3e, 4a, and 4b also showed moderate activity due to the presence of imide functionality.…”

Comparative effect ofN-substituted dehydroamino acids and α-tocopherol on rat liver lipid peroxidation activities

“…. OH is the most efficient ROS to do that attack [33,34]. This peroxidation process is inhibited by compounds such as tocopherols, mannitol and formate.…”

Synthesis, antioxidant and antimicrobial evaluation of simple aromatic esters of ferulic acid

“…OH • is known as the most efficient ROS to initiate LP (Caliskan-Ergün et al, 2008). In the present study, the LP system forms MDA which can be readily detected by TBA and was used to assess OH • formation.…”