Screening and Evaluation of Bioactive Components of Methanol Root Extract of Anthocleista nobilis G. Don. by GCMS Analysis

Abstract

Background: Medicinal plants have great importance in African medicine and are also used as precursors in drug discovery. The medicinal value of plants lies in their bioactive constituents which usually allow them to fight against several diseases. Plant-based natural constituents can be derived from any part of the plant like roots, bark, leaves, flowers, fruits, seeds. The present study was designed to determine the bioactive/biochemical compounds present in the methanol extract of Anthocleista nobilis root.Materials and Methods: GC -MS analysis of the methanol extract of A. nobilis root was performed using a Perkin Elmer GC Clarus 500 system comprising an Agilent technologies 5975 MSD model detector and a gas chromatograph interfaced to a mass spectrometer with the aid of the Turbo mass 5.0 software.Results: The study results of the GC-MS analysis provided different phytochemical compounds possessing several biological activities such as antimicrobial, antifungal, anticancer, and anti-inflammatory activities. This study therefore, showed that root of Anthocleista nobilis is a source of biologically active metabolites. Furthermore, root extract revealed the presence of diverse chemical constituents.Conclusion: The results of the present study suggest a recommendation of A. nobilis root as a plant of phytopharmaceutical importance.

Phytochemical and Bioactive Compounds of Cocoa Beans as Supplement Ingredient Affected by Drying Methods

“…Freeze drying generated more volatile compounds in cocoa beans than other drying methods, followed by cabinet and sun drying. The PCA figure shows that the volatile compound of cocoa beans dried by freeze drying characterized by 1-(3-Methoxy-2-pyrazinyl)-2methyl-1-propanone (24), which was responsible for -nutty scent [19]; 5-Hydroxymethylfurfural (33) is formed by thermal processing (roasting) [20] and methyl eicosanoate (1). Cocoa beans dried by sun drying were characterized by linoleic acid (19) and caffeine (68), and theobromine (69) were the signature of cocoa beans dried with cabinet drying.…”

“…2,4-Di-tertbutylphenol [23], 5-Hydroxymethylfurfural [24], and palmitic acid. Palmitic acid exhibits anti-inflammatory and metabolic regulatory effects and antitumor activities in several tumors [25].…”