2020
DOI: 10.1155/2020/5684250
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Screening and Functional Pathway Analysis of Pulmonary Genes Associated with Suppression of Allergic Airway Inflammation by Adipose Stem Cell-Derived Extracellular Vesicles

Abstract: Background. Although mesenchymal stem cell- (MSC-) derived extracellular vesicles (EVs) are as effective as MSCs in the suppression of allergic airway inflammation, few studies have explored the molecular mechanisms of MSC-derived EVs in allergic airway diseases. The objective of this study was to evaluate differentially expressed genes (DEGs) in the lung associated with the suppression of allergic airway inflammation using adipose stem cell- (ASC-) derived EVs. Methods. C57BL/6 mice were sensitized to ovalbum… Show more

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Cited by 16 publications
(13 citation statements)
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“…Our systematic searches yielded a total of 1167 records (Figure 1 ). Following level 1 screening of titles and abstracts, 434 articles underwent level 2 full‐text screening which resulted in a total of 52 studies included for our systematic review (Ahn et al., 2018 ; Aliotta et al., 2017 , 2016 ; Bandeira et al., 2018 ; Braun et al., 2018 ; Chaubey et al., 2018 ; Chen et al., 2014 , 2019 , 2020 ; Choi et al., 2014 ; Cruz et al., 2015 ; de Castro et al., 2017 ; Deng et al., 2020 ; Dinh et al., 2020 ; Fang et al., 2020a , 2020b ; Gao et al., 2020 ; Hao et al., 2019 ; Harrell et al., 2020 ; Hogan et al., 2019 ; Huang et al., 2019 ; Khatri et al., 2018 ; Kim et al., 2020 ; Klinger et al., 2020 ; Lee et al., 2012 ; Lei et al., 2020 ; Li et al., 2015 , 2019a , 2019b , 2020 ; Liu et al., 2018 , 2019a , 2019b ; Mansouri et al., 2019 ; Maremanda et al., 2019 ; Monroe et al., 2020 ; Monsel et al., 2015 ; Porzionato et al., 2019 ; Potter et al., 2018 ; Silva et al., 2019 ; Stone et al., 2017 ; Tang et al., 2017 ; Varkouhi et al., 2019 ; Wang et al., 2020 ; Willis et al., …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Our systematic searches yielded a total of 1167 records (Figure 1 ). Following level 1 screening of titles and abstracts, 434 articles underwent level 2 full‐text screening which resulted in a total of 52 studies included for our systematic review (Ahn et al., 2018 ; Aliotta et al., 2017 , 2016 ; Bandeira et al., 2018 ; Braun et al., 2018 ; Chaubey et al., 2018 ; Chen et al., 2014 , 2019 , 2020 ; Choi et al., 2014 ; Cruz et al., 2015 ; de Castro et al., 2017 ; Deng et al., 2020 ; Dinh et al., 2020 ; Fang et al., 2020a , 2020b ; Gao et al., 2020 ; Hao et al., 2019 ; Harrell et al., 2020 ; Hogan et al., 2019 ; Huang et al., 2019 ; Khatri et al., 2018 ; Kim et al., 2020 ; Klinger et al., 2020 ; Lee et al., 2012 ; Lei et al., 2020 ; Li et al., 2015 , 2019a , 2019b , 2020 ; Liu et al., 2018 , 2019a , 2019b ; Mansouri et al., 2019 ; Maremanda et al., 2019 ; Monroe et al., 2020 ; Monsel et al., 2015 ; Porzionato et al., 2019 ; Potter et al., 2018 ; Silva et al., 2019 ; Stone et al., 2017 ; Tang et al., 2017 ; Varkouhi et al., 2019 ; Wang et al., 2020 ; Willis et al., …”
Section: Resultsmentioning
confidence: 99%
“…Disease was induced by intraperitoneal delivery of ovalbumin (N = 3) (De Castro et al., 2017 ; Fang et al., 2020a ; Kim et al., 2020 ), Aspergillus fumigatus hyphal extract (N = 1) (Cruz et al., 2015 ), or IL‐33 (N = 1) (Fang et al., 2020b ). MSC‐EVs were administered by intravenous injection in 4 studies, with one study using intranasal delivery for more localized lung distribution.…”
Section: Resultsmentioning
confidence: 99%
“…The interest in AT-MSC-EVs has increasingly grown, due to the wide range of AT sources and their relatively easy accessibility [9]. AT-MSC-EVs have been isolated not only from human cells, but also from mouse [24][25][26][27][28][29][30][31][32], rat [33,34], pig [35][36][37][38], and rabbit [39,40] cells. The main objective of most published studies on AT-MSC-EVs was to evaluate their potential use as a new therapeutic approach to treat various diseases.…”
Section: Introductionmentioning
confidence: 99%
“…As in our previous studies [11,[23][24][25], adipose tissue was harvested from the abdominal fat of C57BL/6 mice. ASCs were cultured (37°C, 5% CO 2 ) in α-modified Eagle's medium (α-MEM) containing 10% fetal bovine serum (FBS) until they reached 1 × 10 6 cells/cm 2 .…”
Section: Ev Extraction and Characterizationmentioning
confidence: 99%
“…A mouse model of asthma was employed with some modifications from previous studies [23][24][25]. The mice were sensitized by intraperitoneal injection with 75 μg of OVA (Sigma-Aldrich) with 2 mg of aluminum hydroxide (Sigma-Aldrich) in 200 μl PBS on days 0, 1, 7, and 8.…”
Section: Mouse Model Of Allergic Airway Inflammationmentioning
confidence: 99%