Screening and Identification of Antipyretic Components in the Postfrost Leaves of <i>Morus alba</i> Based on Multivariable and Continuous-Index Spectrum-Effect Correlation

Qu, Yongsheng; Wang, Liang; Guo, Wei

doi:10.1155/2019/8796276

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…The extract-induced ATF3 expression was dependent on ROS and GSK3β. The extract-induced downregulation of cyclin D1 was caused by ROS-dependent proteasome degradation (Qu et al 2019).…”

Section: Anti-cancer Effectsmentioning

confidence: 97%

Morus alba: a comprehensive phytochemical and pharmacological review

Batiha

Al-Snafi

Thuwaini

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Morusalba is a fast-growing shrub or medium-sized tree with a straight, cylindrical trunk. Medicinally, whole plants, leaves, fruits, branches, and roots have been employed. Google Scholar, PubMed, Scopus, and Web of Science were used to search for relevant material on the phytochemical components and pharmacologic and mechanism of action of the Morus alba. This was reviewed to assess important updates about Morus alba. The fruits of Morus alba have traditionally been used as an analgesic, anthelmintic, antibacterial, anti-rheumatic, diuretic, hypotensive, hypoglycemia, purgative, restorative, sedative tonic, and blood stimulant. Various plant parts were used as a cooling, sedating, diuretic, tonic, and astringent agent to treat nerve disorders. The plant contained tannins, steroids, phytosterols, sitosterol, glycosides, alkaloids, carbohydrates, proteins, and amino acids, as well as saponins, triterpenes, phenolics, flavonoids, benzofuran derivatives, anthocyanins, anthraquinones, glycosides, vitamins, and minerals. Previous pharmacological research identified antimicrobial, anti-inflammatory, immunological, analgesic, antipyretic, antioxidant, anti-cancer, antidiabetic, gastrointestinal, respiratory, cardiovascular, hypolipidemic, anti-obesity, dermatological, neurological, muscular, and protecting effects. This study looked at Morus alba’s traditional uses, chemical components, and pharmacological effects.

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“…The extract-induced ATF3 expression was dependent on ROS and GSK3β. The extract-induced downregulation of cyclin D1 was caused by ROS-dependent proteasome degradation (Qu et al 2019).…”

Section: Anti-cancer Effectsmentioning

confidence: 97%

Morus alba: a comprehensive phytochemical and pharmacological review

Batiha

Al-Snafi

Thuwaini

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Screening Antioxidant Components in Yiwei Decoction Using Spectrum‐Effect Relationship and Network Pharmacology

Zhang,

Zhu

2024

Journal of Analytical Methods in Chemistry

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Yiwei decoction (YWD) is a classic prescription with the function of nourishing stomach yin. In this study, the effective components of antioxidant activity of YWD and its possible mechanism were discussed from the point of view of spectral effect relationship and network pharmacology. Firstly, the fingerprints of 10 batches of YWD were established by UPLC‐PDA technique, and the 1,1‐diphenyl‐2‐picryl‐hydrazyl radical (DPPH) scavenging rate and total antioxidant capacity (T‐AOC) were used as the indicators for antioxidant activity in vitro. Then, the spectral effect relationship between the fingerprint profiles and antioxidant capacity was analyzed through grey relational analysis (GRA) and orthogonal projections to latent structures (OPLS). In addition, network pharmacology was employed to predict the potential mechanisms of YWD in the treatment of antioxidant‐related diseases. The spectrum‐effect relationship indicated that three common peaks were likely to be the most decisive active components, identified as verbascoside, psoralen, and vitexin, respectively. Based on network pharmacology analysis, a total of 83 target genes shared by the active components and antioxidant‐related diseases were collected. AKT1, HSP90AA1, SRC, CASP3, and MTOR were closely related to antioxidant therapy and considered as core therapeutic targets. The potential mechanisms of YWD were obtained through gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, molecular docking simulations were conducted to evaluate the binding activities between the core therapeutic targets and corresponding compounds. The excellent core protein‐compound complexes obtained by molecular docking were simulated by molecular dynamics simulation. The results showed that the active compounds had good binding ability with the selected targets. This study successfully identified the effective components of YWD and predicted the potential targets and pathways, which provided a new idea for the application of YWD in the treatment of antioxidant stress in the future. In addition, the potential active components provide valuable implications for drug screening of related diseases.

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Comprehensive overview of different medicinal parts from Morus alba L.: chemical compositions and pharmacological activities

Wang,

Ai,

et al. 2024

Front. Pharmacol.

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Morus alba L., a common traditional Chinese medicine (TCM) with a centuries-old medicinal history, owned various medicinal parts like Mori folium, Mori ramulus, Mori cortex and Mori fructus. Different medical parts exhibit distinct modern pharmacological effects. Mori folium exhibited analgesic, anti-inflammatory, hypoglycemic action and lipid-regulation effects. Mori ramulus owned anti-bacterial, anti-asthmatic and diuretic activities. Mori cortex showed counteraction action of pain, inflammatory, bacterial, and platelet aggregation. Mori fructus could decompose fat, lower blood lipids and prevent vascular sclerosis. The main chemical components in Morus alba L. covered flavonoids, phenolic compounds, alkaloids, and amino acids. This article comprehensively analyzed the recent literature related to chemical components and pharmacological actions of M. alba L., summarizing 198 of ingredients and described the modern activities of different extracts and the bioactive constituents in the four parts from M. alba L. These results fully demonstrated the medicinal value of M. alba L., provided valuable references for further comprehensive development, and layed the foundation for the utilization of M. alba L.

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Screening and Identification of Antipyretic Components in the Postfrost Leaves of Morus alba Based on Multivariable and Continuous-Index Spectrum-Effect Correlation

Cited by 3 publications

References 17 publications

Morus alba: a comprehensive phytochemical and pharmacological review

Morus alba: a comprehensive phytochemical and pharmacological review

Screening Antioxidant Components in Yiwei Decoction Using Spectrum‐Effect Relationship and Network Pharmacology

Comprehensive overview of different medicinal parts from Morus alba L.: chemical compositions and pharmacological activities

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