Screening and Identification of Key Genes in Hepatitis B Virus-Related Hepatocellular Carcinoma Through an Integrated Bioinformatics Approach

Nguyen, Thi Viet Ha; Vu, Nga Phuong; Tran, Trung Sy; Hoang, Hieu Van; Bui, Hoai T T

doi:10.31557/apjcb.2022.7.2.143-149

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…The chronic infection of HBV, which affects approximately 257 million individuals worldwide and results in 887,000 annual deaths [1], has been reported to be accountable for acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma worldwide [2][3][4][5]. Rezaei et al [6] recorded a reduction in the occurrence of hepatitis B infection in Iran, whereby the frequency dwindled from 3.02% in 2000 to 1.09% in 2016.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B Virus Markers among the Women with Breast Cancer

Fakheri Sueini,

Parsa Nahad,

Talaeizadeh

et al. 2024

Asian Pac J Cancer Prev

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Introduction: Breast cancer represents a formidable peril to the female populace on a worldwide level. The association between breast cancer and various factors, including viral infections, has been extensively investigated. Recently, the link between HBV infection and breast cancer patients has garnered attention. The present research aims to assess the prevalence of HBV markers among women diagnosed with breast cancer in Ahvaz city, Iran. Materials and Methods: Serum specimens were procured from 90 patients who had been clinically diagnosed with breast cancer. The age of the patients ranged from 29 to 80 years, with a mean age of 49.42±10.7. Histological examination of biopsy specimens revealed that 75 (83.33%) were ductal, 11 (8.88%) lobular, 2 (2.22%) mucinous, 1 (1.11%) medullary, and 1 (1.11%) was metastatic. The serum samples were subjected to initial HBsAg and anti-HBc testing via ELISA. Samples that tested seropositive (HBsAg + anti-HBc) were subsequently analyzed for the S region of HBV through nested PCR and DNA sequencing. Finally, a phylogenetic tree was constructed for positive HBV DNA tests. Results: Among the 5/90 (5.55%) cancer patients, it was found that 3 (3.33%) cases of ductal carcinoma and one (1.11%) lobular carcinoma displayed positivity for HBV markers (HBsAg, anti-HBc, HBV PCR). Notably, one (1.11%) patient with ductal carcinoma solely demonstrated anti-HBc positivity. The phylogenetic tree analysis of the S region revealed that all HBV strains identified were categorized as genotype D. Conclusion: The statistical analysis did not reveal any significant findings (p= 0.315) in the distribution of cancer types across different age groups. Among patients diagnosed with breast cancer, a notable prevalence of 5.5% was observed in HBV markers. The dominant HBV genotype among breast cancer patients was identified as genotype D.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B Virus Markers among the Women with Breast Cancer

Fakheri Sueini,

Parsa Nahad,

Talaeizadeh

et al. 2024

Asian Pac J Cancer Prev

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“…Etiological factors of the disease include infection with the hepatitis B or C virus or exposure to high levels of dietary aflatoxin B1 (Yang et al, 2020). It was proved that CCNB1, CDK1, TOP2A, RACGAP1, and ASPM genes could be potential prognostic biomarkers and therapeutic targets for HBV-associated HCC (Nguyen, 2022). Oxidative stress among these patients was also proved to aggravate hepatocarcinogenesis (Nour, 2022).…”

Section: Introductionmentioning

confidence: 99%

Plasma Insulin/Erythrocytic Aldose Reductase Ratio as a Predictor for Hepatocellular Carcinoma among Type II Diabetics and Hepatitis C Virus-Iinfected Patients

Abdel-Hamid

Sherif

Samahy

et al. 2022

Asian Pac J Cancer Prev

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Background: Hepatocellular carcinoma (HCC) is a possible oncogenic progression during persistent hepatitis C-infection +/-type II diabetes mellitus (DM). We aim to investigate the plasma insulin, erythrocytic aldose reductase (AR) and sorbitol dehydrogenase (SDH) as possible predictive tools for HCC in hepatitis C-infected patients (HCV) +/-DM. Erythrocytes (RBCs) were adopted as a possible vehicle for pre-malignant variations being of short life span. Methods:The study included 20 healthy control and 100 patients of 48-64 years old, divided into 5 equal groups as; type II DM, HCC, HCC with DM, DM-HCV infected and non-DM HCV infected. Plasma levels of AFP and insulin were measured. Results: It showed an elevated AR, significant reduction of SDH in RBCs and plasma of DM patients. These values were greatly elevated among HCV, HCC, diabetic HCV, and diabetic HCC patients. All DM patients showed elevated insulin levels than normoglycemic controls. Conclusion: The study substantiated the use of RBCs as a vehicle for early diagnostic markers better than plasma. We recommend the use of insulin/ erythrocytic AR ratio as a new laboratory marker for predicting HCC among type II diabetics or non-treated HCV-infected patients with control insulin/ erythrocytic AR ratio by each laboratory.

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“…Countries with areas with a high incidence of HCC (50 to 120 cases per 100,000 people per year) include China, Taiwan, Korea, and other Southeast Asian countries, plus sub-Saharan Africa. The incidence of HCC is directly related to increasing age (5). Of course, this ratio is different in different countries.…”

Section: Introductionmentioning

confidence: 99%