Abstract:A common strategy to identify new antiparasitic agents is the targeting of proteases due to their essential contribution to parasite growth and development. Metacaspases (MCAs) are cysteine proteases present in fungi, protozoa and plants. These enzymes, which are associated with crucial cellular events in trypanosomes, are absent in the human host, thus arising as attractive drug targets. To find new MCA inhibitors with trypanocidal activity, we adapted a continuous fluorescent enzymatic assay to a medium-thro… Show more
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