2022
DOI: 10.3389/fonc.2021.784096
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Screening and Identification of Novel Potential Biomarkers for Breast Cancer Brain Metastases

Abstract: Brain metastases represent a major cause of mortality among patients with breast cancer, and few effective targeted treatment options are currently available. Development of new biomarkers and therapeutic targets for breast cancer brain metastases (BCBM) is therefore urgently needed. In this study, we compared the gene expression profiles of the brain metastatic cell line MDA-MB-231-BR (231-BR) and its parental MDA-MB-231, and identified a total of 84 genes in the primary screening through a series of bioinfor… Show more

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Cited by 7 publications
(7 citation statements)
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“…Then, the protein–protein interaction network (PPIs) information of these DEGs was predicted by the STRING database (version 11.5) [ 34 ]. After mapping the DEGs into this database, and a combined score ≥ 0.4 was exported [ 35 ]. Then, the PPIs of these DEGs were visualized in Cytoscape, and the hub genes among the PPI network were identified and ranked using the CytoHubba plugin and the maximal clique centrality (MCC) method of Cytoscape software (Version 3.8.2; The Cytoscape Consortium, New York, NY, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Then, the protein–protein interaction network (PPIs) information of these DEGs was predicted by the STRING database (version 11.5) [ 34 ]. After mapping the DEGs into this database, and a combined score ≥ 0.4 was exported [ 35 ]. Then, the PPIs of these DEGs were visualized in Cytoscape, and the hub genes among the PPI network were identified and ranked using the CytoHubba plugin and the maximal clique centrality (MCC) method of Cytoscape software (Version 3.8.2; The Cytoscape Consortium, New York, NY, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Breast cancer is the most commonly diagnosed cancer in women worldwide ( Arnold et al, 2022 ), with an estimated 10%–35% of breast cancer patients developing metastasis to the brain ( Tsukada et al, 1983 ; Patanaphan et al, 1988 ; Willett et al, 2015 ). Breast-cancer brain metastases (BCBM) currently represent an incurable event ( Wang et al, 2021 ), with over 80% of patients succumbing to end-stage disease within a year of diagnosis ( Dawood et al, 2012 ; Arnold et al, 2022 ). Limited therapeutic interventions, including surgical resection, whole brain radiation, and chemotherapy, are often ineffective and yield detrimental effects on healthy brain tissue, thereby profoundly diminishing the quality of life of affected patients ( Leone and Leone, 2015 ; Wang et al, 2021 ; Watase et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…Breast-cancer brain metastases (BCBM) currently represent an incurable event [5], with over 80% of patients losing their lives within a year of diagnosis [1, 6]. Limited therapeutic interventions, including surgical resection, whole brain radiation, and chemotherapy, are often ineffective and yield detrimental effects on healthy brain tissue, thereby profoundly diminishing the quality of life of affected patients [5, 7, 8]. Thus, there is an urgent need to identify small molecules that can block tumor growth in the brain.…”
Section: Introductionmentioning
confidence: 99%
“…Breast cancer is the most commonly diagnosed cancer in women worldwide [1], with an estimated 10-35% of breast cancer patients developing metastasis to the brain [2][3][4]. Breast-cancer brain metastases (BCBM) currently represent an incurable event [5], with over 80% of patients losing their lives within a year of diagnosis [1,6]. Limited therapeutic interventions, including surgical resection, whole brain radiation, and chemotherapy, are often ineffective and yield detrimental effects on healthy brain tissue, thereby profoundly diminishing the quality of life of affected patients [5,7,8].…”
Section: Introductionmentioning
confidence: 99%