2024
DOI: 10.1021/cbmi.4c00076
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Screening Anti-Parkinson’s Disease Drugs in Living Mouse Brains via a Peroxynitrite-Activated Fluorescent Probe

Jiao Wu,
Xiaoyu Wang,
Jingwen Zou
et al.

Abstract: Screening anti-Parkinson's disease (PD) drugs at in vivo brain level is imperative for managing PD yet currently remains unaccomplished. Peroxynitrite (ONOO − ) has been implicated in PD progression. Thus, developing in vivo ONOO − -based imaging tools for anti-PD drug screening holds promise for early prognosis and treatment of PD. Consequently, a near-infrared (NIR) fluorescence probe, BOB-Cl-PN, with high specificity, good sensitivity (LOD = 24 nM), and rapid response (<60 s), was devised to investigate ONO… Show more

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