Screening Arrays of Laminin Peptides on Modified Cellulose for Promotion of Adhesion of Primary Endothelial and Neural Precursor Cells

Wetzel, Richard A.; Hauser, Sandra; Lin, Weilin; Berg, Peggy; Werner, Carsten; Pietzsch, Jens; Kempermann, Gerd; Zhang, Yixin

doi:10.1002/adbi.201900303

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…The irradiation of the slide with light at 366 nm facilitated the release of sufficient substances for MS measurement. [ 23 ] Thus, the four products of the Ugi reaction were confirmed by MS (Figure 3C; Table S4, Supporting Information). Therefore, the G4 substrate can be utilized for the combinatorial array synthesis via the Ugi reaction, while other multicomponent reactions will be explored in the future.…”

Section: Resultsmentioning

confidence: 85%

Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening

et al. 2021

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The in situ synthesis of biomolecules on glass surfaces for direct bioscreening can be a powerful tool in the fields of pharmaceutical sciences, biomaterials, and chemical biology. However, it is still challenging to 1) achieve this conventional multistep combinatorial synthesis on glass surfaces with small feature sizes and high yields and 2) develop a surface which is compatible with solid‐phase syntheses, as well as the subsequent bioscreening. This work reports an amphiphilic coating of a glass surface on which small droplets of polar aprotic organic solvents can be deposited with an enhanced contact angle and inhibited motion to permit fully automated multiple rounds of the combinatorial synthesis of small‐molecule compounds and peptides. This amphiphilic coating can be switched into a hydrophilic network for protein‐ and cell‐based screening. Employing this in situ synthesis method, chemical space can be probed via array technology with unprecedented speed for various applications, such as lead discovery/optimization in medicinal chemistry and biomaterial development.

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Section: Resultsmentioning

confidence: 85%

Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening

et al. 2021

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“…Pathway Modification method Finding RGD Promote the adhesion and migration of ECs through integrin recognition. 107,108 Covalent grafting 109 1. That the structure and density distribution of RGD peptides on the material surface are closely related to their functions.…”

Section: Peptidementioning

confidence: 99%

Endothelialization strategy of implant materials surface: The newest research in recent 5 years

Bian

Chen

Weng

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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In recent years, more and more metal or non-metal materials have been used in the treatment of cardiovascular diseases, but the vascular complications after transplantation are still the main factors restricting the clinical application of most grafts, such as acute thrombosis and graft restenosis. Implant materials have been extensively designed and surface optimized by researchers, but it is still too difficult to avoid complications. Natural vascular endodermis has excellent function, anti-coagulant and anti-intimal hyperplasia, and it is also the key to maintaining the homeostasis of normal vascular microenvironment. Therefore, how to promote the adhesion of endothelial cells (ECs) on the surface of cardiovascular materials to achieve endothelialization of the surface is the key to overcoming the complications after implant materialization. At present, the surface endothelialization design of materials based on materials surface science, bioactive molecules, and biological function intervention and feedback has attracted much attention. In this review, we summarize the related research on the surface modification of materials by endothelialization in recent years, and analyze the advantages and challenges of current endothelialization design ideas, explain the relationship between materials, cells, and vascular remodeling in order to find a more ideal endothelialization surface modification strategy for future researchers to meet the requirements of clinical biocompatibility of cardiovascular materials.

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Screening Arrays of Laminin Peptides on Modified Cellulose for Promotion of Adhesion of Primary Endothelial and Neural Precursor Cells

Cited by 2 publications

References 56 publications

Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening

Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening

Endothelialization strategy of implant materials surface: The newest research in recent 5 years

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