Screening, construction, and serological identification of the diagnostic antigen molecule EG-06283 for the diagnosis of Echinococcus granulosus

Zhu, Yazhou; Zhang, Tingrui; Zhao, Yinqi; Wang, Yin; Lv, Yongxue; Li, Shasha; Yang, Songhao; Zhu, Mingzhao; Wang, Zhao; Wang, Qiang

doi:10.1007/s00436-021-07183-y

Cited by 2 publications

(1 citation statement)

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“…Besides serum immunoglobulin detected by ELISA, new antigens such as the protein membrane EG-06283, antigen 5, and antigen B are emerging as potential markers for the disease. Rapid diagnosis in endemic countries may improve control with medication and lower the need for surgical treatment [ 35 , 36 ]. The sensitivity and specificity for the diagnosis of EG-06283 are 92.59% and 84.62%, respectively, and while using antigen B, antigen 5, and IgG, sensitivity reaches 97%, and specificity reaches 95.7%.…”

Section: Discussionmentioning

confidence: 99%

Complicated Liver Cystic Echinococcosis—A Comprehensive Literature Review and a Tale of Two Extreme Cases

Calu,

Enciu,

Toma

et al. 2024

Tomography

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Cystic echinococcosis is a zoonotic parasitic disease that affects the liver in more than 70% of cases, and there is still an underestimated incidence in endemic areas. With a peculiar clinical presentation that ranges from paucisymptomatic illness to severe and possibly fatal complications, quality imaging and serological studies are required for diagnosis. The mainstay of treatment to date is surgery combined with antiparasitic agents. The surgical armamentarium consists of open and laparoscopic procedures for selected cases with growing confidence in parenchyma-sparing interventions. Endoscopic retrograde cholangiopancreatography (ERCP) is extremely useful for the diagnosis and treatment of biliary fistulas. Recent relevant studies in the literature are reviewed, and two complex cases are presented. The first patient underwent open surgery to treat 11 liver cysts, and during the follow-up, a right pulmonary cyst was diagnosed that was treated by minimally invasive surgery. The second case is represented by the peritoneal rupture of a giant liver cyst in a young woman who underwent laparoscopic surgery. Both patients developed biliary fistulas that were managed by ERCP. Both patients exhibited a non-specific clinical presentation and underwent several surgical procedures combined with antiparasitic agents, highlighting the necessity of customized treatment in order to decrease complications and successfully cure the disease.

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Section: Discussionmentioning

confidence: 99%