Screening, crystal structures and solubility studies of a series of multidrug salt hydrates and cocrystals of fenamic acids with trimethoprim and sulfamethazine

Bhattacharya, Biswajit; Das, Susobhan; Lal, Garima; Soni, Saundray Raj; Ghosh, Animesh; Reddy, C. Malla; Ghosh, Soumyajit

doi:10.1016/j.molstruc.2019.127028

Cited by 50 publications

(33 citation statements)

References 44 publications

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“…Commonly, Fourier transform infra-red (FTIR), thermal analysis (differential scanning calorimetry/DSC, differential thermal analysis/DTA, and thermogravimetry/TG), powder X-ray diffractometry/PXRD, and single-crystal X-ray diffractometry/SCXRD are used to confirm the presence of a new solid phase. Based on the IR spectrum, a shift in the C=O peaks of the two co-crystals, indicating no proton transfer to carboxylic acids [ 30 , 31 ] and decreases in the frequency, showed that the functional groups play a role in the formation of strong hydrogen bonds. Several analysis methods using FTIR have been developed, including the multivariate curve resolution alternating least squares (MCR–ALS) method developed for IBU–NIC co-crystal analysis.…”

Section: Co-crystalmentioning

confidence: 99%

“…Thermal analysis with TGA and DSC is an adequate method to detect the new solid phase formation. The sharp thermogram indicates the purity and homogeneity of the co-crystal and good thermal stability [ 30 ]. DSC analysis exhibits the unique thermal melting point of the co-crystal, which differs from those of the parent drugs [ 31 , 33 ].…”

Section: Co-crystalmentioning

confidence: 99%

“…This combination aimed to provide a unique combination drug or pain relief therapy and prevent postoperative infections. Hence, it minimizes or even replaces the use of opioids, reduces adverse effects, and improves the physicochemical properties of each API [ 30 ]. For example, niflumic acid (NFA)–caprolactam (CPR) (1:1) is an example of an anthranilic acid class of NSAID that selectively inhibits COX-2 and is widely used in patients with rheumatoid arthritis.…”

Section: Progress On Nsaid Co-crystalsmentioning

confidence: 99%

“…Then, each dimer unit is connected by four pairs of identical NH···O hydrogen bonds to form synthon IV. This structure is stabilized by CH···interactions and π···π interactions [ 30 ].…”

Section: Progress On Nsaid Co-crystalsmentioning

confidence: 99%

“…This list includes various chemicals, including aldehydes, alcohols, carboxylic acids, amides, and sweeteners. Therefore, the structural diversity and the physicochemical properties of the substances in the GRAS list provide an additional means of selecting co-formers [ 30 ].…”

Section: Challenges In Nsaid Co-crystal Developmentmentioning

confidence: 99%

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Challenges and Progress in Nonsteroidal Anti-Inflammatory Drugs Co-Crystal Development

Nugrahani

Parwati

2021

Molecules

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Co-crystal innovation is an opportunity in drug development for both scientists and industry. In line with the “green pharmacy” concept for obtaining safer methods and advanced pharmaceutical products, co-crystallization is one of the most promising approaches to find novel patent drugs, including non-steroidal anti-inflammatory drugs (NSAID). This kind of multi-component system improves previously poor physicochemical and mechanical properties through non-covalent interactions. Practically, there are many challenges to find commercially viable co-crystal drugs. The difficulty in selecting co-formers becomes the primary problem, followed by unexpected results, such as decreased solubility and dissolution, spring and parachute effect, microenvironment pH effects, changes in instability, and polymorphisms, which can occur during the co-crystal development. However, over time, NSAID co-crystals have been continuously updated regarding co-formers selection and methods development.

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Section: Co-crystalmentioning

confidence: 99%

Section: Co-crystalmentioning

confidence: 99%

Section: Progress On Nsaid Co-crystalsmentioning

confidence: 99%

Section: Progress On Nsaid Co-crystalsmentioning

confidence: 99%

Section: Challenges In Nsaid Co-crystal Developmentmentioning

confidence: 99%

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