Screening cytomegalovirus, rubella and toxoplasma infections in pregnant women with unknown pre-pregnancy serological status

Karacan, Meriç; Batukan, Melike; Cebi, Z.; Berberoglugil, M.; Levent, Semra; Kır, Mustafa; Baksu, Alpaslan; E, Ozel; Çamlibel, T.

doi:10.1007/s00404-014-3340-3

Cited by 36 publications

(37 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This result is in accordance with reports from Turkey (14,15), in which the CMV seropositivity rate was ranging from 84.5% to 97.3%. However, In a study performed among Turkish women living in an urban area, The prevalence of seropositivity was found 84.1%, which is lower than those reported in other parts of Turkey (16). A major factor contributing to this decline may be the decreased risk of CMV infection because of improved life standards in urban Turkish population.…”

Section: Discussionmentioning

confidence: 62%

Screening Cytomegalovirus Infections in First Trimester of Gestation Among High Prevalence Population

Usta¹,

Taşkın²,

Usta³

et al. 2016

Acta Med Anatol

View full text Add to dashboard Cite

Introduction: Cytomegalovirus (CMV) is known as a major cause of congenital viral infection in humans. The aim of this study was to evaluate the rate of CMV infection and identify risk factors for infection by screening pregnant women in high prevalence population. Methods:A retrospective study was conducted between January 2014 and December 2014 in women presenting for their first antenatal visit (between 6-12 weeks of gestation). All women were tested for IgG and IgM antibodies. Subsequently, avidity test was used to discriminate between primary or non-primary CMV infection. They were followed until delivery and newborns were examined by a pediatrician.Results: A total of 3212 pregnant women were screened during the study period. The rate of seropositivity and seronegativity were found as 97.9% and 2.1% respectively. The prevalence of maternal CMV infection was found as 1.1% (34 women). Among these women, the rate of primary and recurrent CMV infection were found to be 0.3% (8 women) and 0.8% (26 women) respectively. Pregnants with primary CMV infection were referred to perinatal care unit. Pregnants with recurrent infection were followed by ultrasonography for the presence of fetal abnormalities. None of the women who completed follow-up until delivery showed gross evidence of in utero CMV transmission. Isolated IgM antibody positivity was not detected in any women. Conclusion:Seroprevalence of CMV infection is very high in our region during the pregnancy. Although, there was no difference in terms of birth weight and gestational age at delivery, detection of primary CMV infection is associated with higher rate of spontaneous abortion.

show abstract

Section: Discussionmentioning

confidence: 62%

Screening Cytomegalovirus Infections in First Trimester of Gestation Among High Prevalence Population

Usta¹,

Taşkın²,

Usta³

et al. 2016

Acta Med Anatol

View full text Add to dashboard Cite

show abstract

“…Rubella courses with mild degree of rashes and fever in childhood, when it is experienced in the first months of pregnancy, it can lead to pregnancy losses and stillbirths and during the neonatal period it may result in “Congenital Rubella Syndrome” (CRS) [1, 2, 3]. For the possible prevention of vertical transmittance from mother to the fetus, seronegative women should be detected during preconceptional period, and their pregnancies should be planned, and postponed after immunization.…”

Section: Discussionmentioning

confidence: 99%

“…They sometimes lead an asymptomatic course, on the other hand they may encounter us with bad prognosis including miscarriages, sterility, congenital malformations and intrauterine fetal loss [1]. When all the cases were evaluated incidence of intrauterine growth retardation secondary to infectious agents was reported as nearly 5 percent.…”

mentioning

confidence: 99%

“…When all the cases were evaluated incidence of intrauterine growth retardation secondary to infectious agents was reported as nearly 5 percent. Prenatal infections have been held responsible from generally 2–3% of all congenital anomalies [1, 2]. …”

mentioning

confidence: 99%

“…In France, screening for Toxoplasma gondii is a must [9, 10]. However, in our country a complete consensus does not exist on this issue [1, 7, 11]. In this study, the seroprevalence of TORCH group of infectious agents among patients who attended to the Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals was evaluated and its use as a screening test was evaluated in the light of the literature.…”

mentioning

confidence: 99%

See 2 more Smart Citations

TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals

Numan

Vural

Aka

et al. 2016

North Clin Istanbul

View full text Add to dashboard Cite

OBJECTIVE:Toxoplasma gondii, Rubella, Cytomegalovirus and Herpes simplex viruses are microorganisms that cause congenital infections and they are called briefly as TORCH. There is an ongoing argument for the screening of reproductive age women due to the high cost of tests. For a test to be used in screening, prevalence of disease in this population should be known. The aim of this study was to investigate TORCH seroprevalence among women attending a teaching hospital in Istanbul.METHODS:A total of 1101 patients attending outpatient clinic of Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals between September 2013 to January 2015 and their laboratory data were evaluated retrospectively. We investigated Ig G and M seropositivity rates against TORCH.RESULTS:The age of the patients ranged between 17–47 years with a mean age of 30.3±5.8 years. Pregnant population had 99.5% anti-CMV Ig G (+), 94.2% anti-Rubella Ig G (+), 31% anti-Toxoplasma Ig G (+). Seroprevalence for Anti IgM was 0.5% for CMV, 0.2% for rubella.CONCLUSION:The screening for Toxoplasma gondii may be suggested since the prevalence is not high in our population. The screening of CMV is not meaningful, due to high seroprevalence. Although seroprevalence of rubella is also high, it may be suggested for preconception vaccination especially in women above 20 years of age born prior to National Vaccination Programme.

show abstract

HCMV seroprevalence in couples under infertility treatment

Kling

Kabelitz

2015

Arch Gynecol Obstet

View full text Add to dashboard Cite

show abstract

Screening cytomegalovirus, rubella and toxoplasma infections in pregnant women with unknown pre-pregnancy serological status

Cited by 36 publications

References 29 publications

Screening Cytomegalovirus Infections in First Trimester of Gestation Among High Prevalence Population

Screening Cytomegalovirus Infections in First Trimester of Gestation Among High Prevalence Population

TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals

HCMV seroprevalence in couples under infertility treatment

Contact Info

Product

Resources

About