Screening, epidemiology, molecular biology, and treatment strategies for endometriosis‐associated ovarian cancer

Kobayashi, Hiroshi

doi:10.1007/s12522-009-0034-9

Cited by 7 publications

(10 citation statements)

References 78 publications

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“…Malignant transformation is a rare complication of endometriosis, affecting 0.6-0.8% of all cases of OE (1). In Japan, clear cell carcinoma is not uncommon and is the second most frequently occurring type of EAOC, accounting for >20% of all EAOC cases (8). In the present case report, transvaginal ultrasonographic findings revealed a large pelvic mass and solid echogenic loculi.…”

Section: Discussionsupporting

confidence: 46%

Magnetic resonance relaxometry improves the accuracy of conventional MRI in the diagnosis of endometriosis‑associated ovarian cancer: A case report

et al. 2019

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Endometriosis is a precancerous condition for endometriosis-associated ovarian cancer (EAOC). In the present study, conventional magnetic resonance imaging (MRI) and MR relaxometry were used to examine a case of clear cell carcinoma that arose in a pre-existing right-sided benign ovarian endometrioma (OE). The 42-year-old nulliparous woman suspected of EOAC, as assessed by conventional MRI, requested fertility-sparing surgery such as laparoscopic endometrioma cystectomy. Furthermore, the MR transverse relaxation rate (R2) was determined using a single-voxel, multi-echo MR sequence using a 3 Tesla-MR system. An R2 value <12.1 s -1 was indicative of malignancy, as described in previous studies. In the present study, MR relaxometry identified an R2 value of 7.98 s -1 in the right cyst, which suggested the malignant transformation of benign OE. Based on these findings, fertility-sparing surgery was contraindicated. In conclusion, MR relaxometry may represent a new clinical approach as an adjunctive modality for the diagnosis of EAOC. When patients exhibiting a pelvic mass suspected of EAOC desire fertility-sparing treatment options, MR relaxometry can facilitate the selection of conservative management.

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Section: Discussionsupporting

confidence: 46%

Magnetic resonance relaxometry improves the accuracy of conventional MRI in the diagnosis of endometriosis‑associated ovarian cancer: A case report

et al. 2019

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“…Seven reviews were found in the literature [4, 7–12], which have addressed the association between endometriosis and ovarian cancer. A summarizing table of the reviews' findings was modified from the Glasgow appraisal tool (Table 1) [6].…”

Section: Resultsmentioning

confidence: 99%

Endometriosis and Ovarian Cancer: A Systematic Review

Sayasneh

Tsivos

Crawford

2011

ISRN Obstetrics and Gynecology

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Introduction. Endometriosis is one of the most common benign disorders which affects 10–15% of all women in reproductive age. The association between endometriosis and ovarian cancer has been frequently described in the medical literature. Purpose. To evaluate the literature for evidence of a correlation between endometriosis and ovarian cancer. Method. the English language literature (online MEDLINE and EMBASE database) was searched using the keywords endometriosis combined with cancer, tumour, tumor, carcinoma, or adenocarcinoma. All abstracts between January 1985 and August 2010 were reviewed. Full relevant articles were critically assessed. Reference lists of included studies were checked. Results. Seven out of the eight studies, included in our review, have shown an increased risk of ovarian cancer. However, the effect size is modest (OR, RR, and SIR) ranging between 1.32 and 1.9 (95% CI). A causative relationship between the two incidences cannot be confirmed. There is increasing evidence on the role of genetic mutations in ovarian clear-cell and endometrioid carcinoma developing from endometriosis. Conclusion. More evidence is needed before suggesting any change in the current management of endometriosis.

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“…Endometriosis is associated with an increased risk of epithelial ovarian cancer development, especially clear cell and endometrioid carcinoma. Although clear cell and endometrioid subtypes are rare among all epithelial ovarian cancers, they are most common in endometriosis-associated ovarian cancer (EAOC) [ 8 , 9 , 16 ]. In our study, clear cell and endometrioid subtypes were found in 8 of 9 patients with invasive carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Association between atypical endometriosis and ovarian malignancies in the real world

Hong

Kim

et al. 2021

J Ovarian Res

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Background To evaluate the clinical outcome of atypical endometriosis and its association with ovarian malignancy. Methods This retrospective study included patients diagnosed with atypical endometriosis between January 2001 and December 2017. All patients had received surgical treatment for ovarian tumor. The clinical characteristics and histopathological results of all patients were reviewed. Results Atypical endometriosis was diagnosed in 101 patients. We analyzed 98 patients with a mean age of 34.8 years (range: 16–58 years). Ten patients (10.2%) had previously undergone endometriosis surgery more than once. In total, 12 (12.2%) patients had atypical endometriosis-associated ovarian malignancy—nine had carcinomas and three had borderline tumor. The tumors were pathologically classified as follows: five, clear cell carcinomas; two, endometrioid adenocarcinomas; one, mixed clear cell and endometrioid adenocarcinoma; one, seromucinous carcinoma; two, mucinous borderline tumors; and one, seromucinous borderline tumor. Conclusion Atypical endometriosis is most frequently associated with clear cell carcinoma and endometrioid adenocarcinoma. To identify the risk of ovarian malignancy and manage patients with endometriosis, diagnosing atypical endometriosis and recognizing its precancerous potential are important.

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Screening, epidemiology, molecular biology, and treatment strategies for endometriosis‐associated ovarian cancer

Cited by 7 publications

References 78 publications

Magnetic resonance relaxometry improves the accuracy of conventional MRI in the diagnosis of endometriosis‑associated ovarian cancer: A case report

Magnetic resonance relaxometry improves the accuracy of conventional MRI in the diagnosis of endometriosis‑associated ovarian cancer: A case report

Endometriosis and Ovarian Cancer: A Systematic Review

Association between atypical endometriosis and ovarian malignancies in the real world

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