Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy

Ökten, Mehmet Şefa; Tülüce, Kamil; Tülüce, Selcen Yakar; Kılıç, Salih; Kemal, Hatice; Sayın, Ahmet; Vuran, Özcan; Yağmur, Bülent; Mutlu, İnan; Şimşek, Evrim; Çınar, Cahide Soydaş; Gürgün, Cemil

doi:10.1007/s00059-016-4498-1

Cited by 8 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 773 studies were obtained from the literature search excluding duplicates, and after reviewing all abstracts, 102 studies passed initial screening for full-text review, and 44 studies were eligible for analysis , totaling 8,910 subjects (Figure 2) (39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57). In one study we were able to obtain unpublished means and standard deviations for LVGLS from the authors (15).…”

Section: Resultsmentioning

confidence: 99%

Determining the thresholds for abnormal left ventricular strains in healthy subjects by echocardiography: a meta-analysis

Wang¹,

Desai²,

Collier³

et al. 2020

Cardiovasc Diagn Ther

View full text Add to dashboard Cite

Background: Left ventricular global longitudinal strain (LVGLS), circumferential strain (LVGCS) and radial strain (LVGRS) are echocardiographic parameters with wide clinical applicability. However, the thresholds for abnormal left ventricular (LV) strains, particularly the lower limits of normal (LLN), are not well established. This meta-analysis determined the mean and LLN of two-(2D) and three-dimensional (3D)LV strain in healthy subjects and factors that influence strain measurements.Methods: We searched PubMed, Embase and Cochrane databases until 31 December 2019 for studies reporting left ventricular (LV) global strain in at least 50 healthy subjects. We pooled means and LLNs of 2D and 3D LV strain using random-effects models, and performed subgroup and meta-regression analysis for LVGLS. Results: Forty-four studies were eligible totaling 8,910 subjects. The pooled means and LLNs (95% confidence intervals) were −20.1% (−20.7%, −19.6%) and −15.4% (−16.0%, −14.7%) respectively for 2D-LVGLS; −21.9% (−23.4%, −20.3%) and −15.3% (−16.9%, −13.8%) respectively for 2D-LVGCS; and 48.4% (43.8%, 53.0%) and 25.5% (17.8%, 33.1%) respectively for 2D-LVGRS. All pooled analyses demonstrated significant heterogeneity, and means and LLNs of and 3D-LV strains differed marginally from 2D. Only vendor software was associated with differences in pooled means and LLN of 2D-LVGLS.Conclusions: In conclusion, pooled means and LLNs of 2D-and 3D-LV global strain parameters in healthy subjects were reported. Based on the pooled LLNs, thresholds for abnormal, borderline and normal strains can be defined, such as less negative than −14.7%, between −14.7% and −16.0% and more negative than −16.0% respectively for 2D-LVGLS, and 2D-LVGLS values are only affected by vendor software.

show abstract

Section: Resultsmentioning

confidence: 99%

Determining the thresholds for abnormal left ventricular strains in healthy subjects by echocardiography: a meta-analysis

Wang¹,

Desai²,

Collier³

et al. 2020

Cardiovasc Diagn Ther

View full text Add to dashboard Cite

show abstract

“…Enlarged LV dimensions contrast with what is seen in hypertrophic cardiomyopathy (HCM), where the earliest findings in genetically mediated, sarcomere-positive HCM are reduced LV dimensions 28 . Strain and strain rate differences can be detected by echocardiography in first degree relatives of those with newly diagnosed nonischemic DCM, indicating that LV dimensions are not the earliest detectable differences in familial DCM 29, 30 .…”

Section: Imaging - Echocardiographymentioning

confidence: 99%

Dilated Cardiomyopathy

McNally

Mestroni

2017

Circulation Research

594

303

View full text Add to dashboard Cite

Nonischemic dilated cardiomyopathy often has a genetic etiology. Because of the large number of genes and alleles attributed to dilated cardiomyopathy, comprehensive genetic testing encompasses ever-increasing gene panels. Genetic diagnosis can help predict prognosis, especially with regard to arrhythmia risk for certain subtypes. Moreover, cascade genetic testing in family members can identify those who are at-risk or with early stage disease, offering the opportunity for early intervention. This review will address diagnosis and management of dilated cardiomyopathy, including the role of genetic evaluation. We will also overview distinct genetic pathways linked to dilated cardiomyopathy and their pathogenetic mechanisms. Historically, cardiac morphology has been used to classify cardiomyopathy subtypes. Determining genetic variants is emerging as an additional adjunct to help further refine subtypes of dilated cardiomyopathy, especially where arrhythmia risk is increased, and ultimately contribute to clinical management.

show abstract

From Hypertrophy to Heart Failure: What Is New in Genetic Cardiomyopathies

Reza

Musunuru

Owens

2019

Curr Heart Fail Rep

View full text Add to dashboard Cite

Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy

Abstract: LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction.

Cited by 8 publications

References 26 publications

Determining the thresholds for abnormal left ventricular strains in healthy subjects by echocardiography: a meta-analysis

Determining the thresholds for abnormal left ventricular strains in healthy subjects by echocardiography: a meta-analysis

Dilated Cardiomyopathy

From Hypertrophy to Heart Failure: What Is New in Genetic Cardiomyopathies

Contact Info

Product

Resources

About