Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties

Battista, Petronilla; Catricalà, Eleonora; Piccininni, Marco; Copetti, Massimiliano; Esposito, V.; Polito, Cristina; Miozzo, Antonio; Gobbi, Elena; Cuoco, Sofia; Boschi, Veronica; Picillo, Marina; Sorbi, Sandro; Barone, Paolo; Iannaccone, Sandro; Garrard, Peter; Logroscino, Giancarlo; Cappa, Stefano F.

doi:10.1159/000492632

Cited by 17 publications

(21 citation statements)

References 20 publications

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“…The present study showed that the PSP-tailored SAND battery is acceptable, reliable, and easily applicable to PSP patients. By removing subscores with high proportion of missing values and expanding subscores of the remaining tasks, we used the best combination of SAND tasks to screen language ability in PSP leading to a significant improvement in consistency and acceptability as compared to the original SAND Global Score [5,15]. As a matter of fact, differently from patients with PPA, PSP patients disclose peculiar clinical features possibly impacting performances on specific language tasks.…”

Section: Discussionmentioning

confidence: 99%

“…This is the first study showing a cut off for a language battery differentiating PSP from PD and HC. Previous evidence showed the SAND cut off of 5 was able in differentiating PPA from patients affected by movement disorders (PD and PSP)[5].…”

Section: Discussionmentioning

confidence: 99%

“…Language was evaluated with the SAND battery [5,6]. The SAND Global Score including the 23 task-related scores was computed according with a previously described process [5]. In brief, the SAND global score is a frequency count of the pathologically impaired sub-scores with higher scores indicating more severe impairment.…”

Section: Methodsmentioning

confidence: 99%

“…The Screening for Aphasia in NeuroDegeneration (SAND) battery is a brief validated tool to detect language impairment in patients affected by neurodegenerative diseases through the assessment of different components of language [5,6]. The SAND battery is proved to detect subtle language impairment in PSP phenotypes other than PSP-SL, such as lexical-semantic level disturbances in comparison with Parkinson’s disease (PD) and healthy controls (HC)[4].…”

Section: Introductionmentioning

confidence: 99%

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Clinical use of SAND battery to evaluate language in patients with Progressive Supranuclear Palsy

et al. 2019

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BackgroundProgressive Supranuclear Palsy (PSP) patients present language disturbances in tasks like naming, repetition, reading, word comprehension and semantic association compared to Parkinson’s disease (PD) and healthy controls (HC).ObjectiveIn the present study we sought to validate a Screening for Aphasia in NeuroDegeneration (SAND) battery version specifically tailored on PSP patients and to describe language impairment in relation to PSP disease phenotype and cognitive status.Methods and resultsFifty-one PSP [23 with Richardson’s syndrome (PSP-RS), 10 with predominant parkinsonism (PSP-P) and 18 with the other variant syndromes of PSP (vPSP)], 28 PD and 30 HC were enrolled in the present study. By excluding the tasks with poor acceptability (i.e., writing and picture description tasks) and increasing the items related to the remaining tasks, we showed that the PSP-tailored SAND Global Score is an acceptable, consistent and reliable tool to screen language disturbances in PSP. However, we failed to detect major differences in language involvement according to disease phenotype. Differently, we showed that patients with dementia present worse language performances.ConclusionsTaking into account specific disease features, the combination of the SAND subscores included in the PSP-tailored SAND better represents language abilities in PSP. Furthermore, we showed that language disturbances feature PSP patients irrespective of disease phenotype, but parallels the deterioration of the global cognitive function.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical use of SAND battery to evaluate language in patients with Progressive Supranuclear Palsy

et al. 2019

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“…Activities of daily living were preserved. At the speech-language examination, he showed isolated semantic deficits, ie, impairment in single-word comprehension, nonverbal semantic association, surface dyslexia and word-finding difficulties as assessed by the Screening for Aphasia in Neurodegeneration battery (SAND) 10,11. At the spontaneous speech task, he showed a low speech rate associated with several false starts and a lot of lexical-semantic errors, ie, word-finding pauses with a tendency to produce high-frequency nouns and poor content resulting in a reduction of information units.…”

Section: Case Reportmentioning

confidence: 99%

<p>Early pathological gambling in co-occurrence with semantic variant primary progressive aphasia: a case report</p>

Battista

Capozzo

Rizzo

et al. 2019

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We have comprehensively documented a case of semantic variant of primary progressive aphasia (sv-PPA) presenting with early-onset pathological gambling (PG). While a growing number of studies have shown the presence of behavioral alterations in patients with sv-PPA, PG has been observed only in the behavioral variant of frontotemporal dementia (bv-FTD). To date, no case of PG with the co-occurrence of prominent semantic deficits at the onset of the disease has been reported in the literature. Impulse disorders at onset may wrongly lead to a misdiagnosis (ie, psychiatric disorders). Therefore, a wider characterization of cognitive/aphasia symptoms in patients presenting impulse disorders and predominant language dysfunctions is recommended.

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The language profile in multiple system atrophy: an exploratory study

et al. 2021

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Background The evidence about the language performance profile of multiple system atrophy (MSA) is limited, but its definition may lead to a more comprehensive characterization of the disorder and contribute to clarify the involvement of the basal ganglia in language abilities. Objective The objectives of the study were: (1) to evaluate the reliability of the Screening for Aphasia in NeuroDegeneration (SAND) in MSA patients; (2) compare the linguistic profiles among MSA and Parkinson’s disease (PD) patients and healthy controls (HC), and (3) assess relationships between language impairment and cognitive status and MSA motor subtypes. Methods and results Forty patients with a diagnosis of MSA, 22 HC and 17 patients with PD were enrolled in the present study. By excluding the writing task that showed a poor acceptability, we showed that the MSA-tailored SAND Global Score is an acceptable, consistent and reliable tool to screen language disturbances in MSA. MSA patients performed worse than HC, but not than PD, in MSA-tailored SAND Global Score, repetition, reading and semantic association tasks. We did not find significant differences between MSA phenotypes. MSA patients with mild cognitive impairment-multiple domain presented worse language performances as compared to MSA patients with normal cognition and mild cognitive impairment-single domain. Conclusion The MSA-tailored SAND Global Score is a consistent and reliable tool to screen language disturbances in MSA. Language disturbances characterize MSA patients irrespective of disease phenotype, and parallel the decline of global cognitive functions.

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Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties

Cited by 17 publications

References 20 publications

Clinical use of SAND battery to evaluate language in patients with Progressive Supranuclear Palsy

Clinical use of SAND battery to evaluate language in patients with Progressive Supranuclear Palsy

<p>Early pathological gambling in co-occurrence with semantic variant primary progressive aphasia: a case report</p>

The language profile in multiple system atrophy: an exploratory study

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