Screening for aspirin resistance in stable coronary artery patients by three different tests

Chakroun, Tahar; Addad, Faouzi; Abderazek, Fatma; Ben-Farhat, Mohamed; Hamdi, Sonia; Gamra, Habib; Hassine, Mohsen; Ben-Hamda, Khaldoun; Samama, M; Elalamy, Ismaı̈l

doi:10.1016/j.thromres.2007.04.010

Cited by 37 publications

(29 citation statements)

References 22 publications

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“…They found that platelet function tests (light transmission aggregometry, whole blood aggregometry, PFA-100 system, VerifyNowAspirin and urinary 11-dehydro-TxB2 concentrations) were not equally effective in measuring aspirin's antiplatelet effect and correlated poorly amongst themselves. Their results have been confirmed by other studies [19][20][21] . On the other hand, a recent study based on healthy volunteers found high concordance (> 90%) between the examined assays (light transmission aggregometry, PFA-100, VerifyNow, and urinary 11-dehydro-TxB2) [22] .…”

Section: Comparism Of Methodssupporting

confidence: 86%

Clinical importance of aspirin and clopidogrel resistance

Fehér

Fehér²,

Pusch³

et al. 2010

WJC

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Section: Comparism Of Methodssupporting

confidence: 86%

Clinical importance of aspirin and clopidogrel resistance

Fehér

Fehér²,

Pusch³

et al. 2010

WJC

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“…No such correlation was observed when ARA was used as the inducer of platelet aggregation in LTA testing. This suggests that the difference between impedance aggregometry and LTA shows different predictive values for various platelet function tests [25, 26]. Several reports have shown that analgesic therapy with NSAIDs have a significant effect on the efficacy of aspirin [10-14].…”

Section: Discussionmentioning

confidence: 99%

Role of Dipyrone in the High On-Treatment Platelet Reactivity amongst Acetylsalicylic Acid-Treated Patients Undergoing Peripheral Artery Revascularisation

et al. 2018

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Objective: To evaluate the effects of dipyrone on sensitivity to aspirin (acetylsalicylic acid [ASA]) in patients who underwent peripheral artery vascular reconstruction. Subjects and Methods: Impedance aggregometry and light transmission aggregometry were used to determine the effects of dipyrone on ASA treatment in 21 patients. Blood samples were drawn in a 7-day period after the surgery. The cut-off value for high on-treatment platelet reactivity (HTPR) was set at < 65% of aggregation inhibition for impedance aggregometry. For light transmission aggregometry the cut-off value for arachidonic acid-induced aggregation was set at > 20% of aggregating platelets, and the cut-off value for epinephrine-induced aggregation was > 44% of aggregating platelets. The cut-off value for each method was derived from a large number of patients treated with a daily dose of 100 mg of ASA. Results: We found HTPR in 14 (67%) of the 21 patients. None had primary resistance to ASA, i.e., after the addition of ASA in vitro all samples showed antiplatelet efficacy. Regression analysis showed a possible correlation between lower efficacy of ASA treatment and higher daily doses of dipyrone (p = 0.005 for impedance aggregometry, p = 0.04 for light transmission aggregometry), higher platelet count (p = 0.005 for impedance aggregometry), and shorter time from surgery (p = 0.03 for impedance aggregometry). Conclusion: HTPR occurs in 67% of ASA-treated patients after lower limb vascular surgery. The occurrence of HTPR correlates with the daily dose of dipyrone. Therefore, dipyrone should not be used as a postoperative analgesic in ASA-treated patients after peripheral artery revascularisation due to its influence on the effectiveness of ASA.

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“…In the first approach, adequate platelet inhibition with ASA is defined as CEPI-CT ≥165 sec, and in the second as CEPI-CT ≥193 sec (the manufacturer's lower limit of the normal range for aspirin-free healthy controls) (12). The maximum CT provided for PFA-100 is 300 sec and is equivalent to non-occlusion (13). Thus, patients with CEPI-CT values ≥300 sec were defined as an alternative population with adequate platelet inhibition (14).…”

Section: Platelet Function Analysismentioning

confidence: 99%

Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes

Rosiak

Postuła

Kapłon‐Cieślicka

et al. 2013

Molecular Medicine Reports

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Abstract. The aim of the present study was to investigate the effect of genetic polymorphisms in candidate genes within the leukotriene (LT) pathway on platelet reactivity and the concentration of selected LTs in diabetic patients treated with acetylsalicylic acid (ASA). The study cohort consisted of 287 Caucasians with type 2 diabetes who had received treatment with ASA tablets (75 mg/day) for at least three months. Platelet reactivity analyses were performed using VerifyNow aspirin and PFA-100 assays. The measured LTs included leukotriene B 4 (LTB 4 ) and leukotriene E 4 (LTE 4 ). Genotyping for the selected 25 single nucleotide polymorphisms (SNPs) within six genes of the LT pathway was performed using a Sequenom iPLEX platform. No statistically significant association was observed between the investigated SNP genotypes, platelet reactivity and measured LTs in the patient cohort. The results of our study suggest that certain polymorphisms of the LT pathway are not associated with altered platelet reactivity and the measured LTs in diabetic patients treated with ASA.

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Screening for aspirin resistance in stable coronary artery patients by three different tests

Cited by 37 publications

References 22 publications

Clinical importance of aspirin and clopidogrel resistance

Clinical importance of aspirin and clopidogrel resistance

Role of Dipyrone in the High On-Treatment Platelet Reactivity amongst Acetylsalicylic Acid-Treated Patients Undergoing Peripheral Artery Revascularisation

Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes

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