Screening for bipolar disorders: A public health issue

Carta, Mauro Giovanni; Angst, Jules

doi:10.1016/j.jad.2016.03.072

Cited by 57 publications

(48 citation statements)

References 47 publications

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“…16 Taking this consideration into account, the low positive predictive value we found in our quality control study, as well as in previous studies, is no wonder, as the gold standard employed is simplistic compared to the wide spectrum of illness that is identified by MDQ positivity.…”

Section: Discussionmentioning

confidence: 57%

“…16 However, the fact that the frequency of MDQ positivity appears high in second-generation migrants but low in first-generation ones does not necessarily mean that the latter had no genetic risk profile for bipolar spectrum disorder. One explanation is that the same genotype may not have manifested as a pathological condition in a 32 the forms of these disorders we know have appeared as mass phenomena at least since the 17th century, we must also postulate that at least some common genotypic features must have an adaptive advantage in determined and specific frameworks; otherwise, mood disorders would have disappeared.…”

Section: Discussionmentioning

confidence: 99%

“…The MDQ is a useful tool for BD screening and identification of lifetime manic/ hypomanic and ''sub-threshold'' hyperactivity episodes, according to the new interpretation of this instrument. 16 According to the Italian 14 and Argentine Spanish validations, 15 a score of at least seven symptoms would identify lifetime presence of bipolarity.…”

Section: Toolsmentioning

confidence: 99%

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An evolutionary approach to mania studying Sardinian immigrants to Argentina

Carta

Perra

Atzeni

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: To ascertain lifetime prevalence of positivity to a screening questionnaire for bipolar disorders (BD) in Sardinian immigrants to Argentina and residents of Sardinia and assess whether such positivity affects quality of life (QoL) in either group. Our hypothesis is that screen positivity for BD may be more frequent in immigrants. Methods: Observational study. Subjects were randomly selected from the membership lists of associations of Sardinian immigrants in Argentina. A study carried out in Sardinia using the same methodology was used for comparison. The Mood Disorder Questionnaire was used to screen for mania/hypomania and the Short-Form Health Survey-12 to measure QoL. Results: A higher prevalence of manic/hypomanic episodes was found in Sardinian immigrants to Argentina (p o 0.0001; odds ratio = 3.0, 95% confidence interval 1.87-4.77). Positivity at screening was associated with a lower QoL both in Sardinian immigrants to Argentina and in residents of Sardinia. Conclusions: To the best of our knowledge, this is the first study to show a higher lifetime prevalence of manic/hypomanic episodes in a general-population sample of individuals who migrated to a foreign country. Our results are in agreement with the hypothesis that hyperactive/novelty-seeking features may represent an adaptive substrate in certain conditions of social change.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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An evolutionary approach to mania studying Sardinian immigrants to Argentina

Carta

Perra

Atzeni

et al. 2017

Rev. Bras. Psiquiatr.

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“…Substance use disorders (SUD) and mental health disorders are significant public health issues that often co-occur and are associated with functional disability [1] and high risk for self-harm, including suicide attempts and completion [2,3,4,5,6,7,8]. The prevalence for SUD and mental health disorders are much greater for the offender population (i.e., prisoners, inmates) than non-imprisoned populations [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Associations among Substance Use, Mental Health Disorders, and Self-Harm in a Prison Population: Examining Group Risk for Suicide Attempt

Gates

Turney²,

Ferguson

et al. 2017

IJERPH

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Substance use disorders (SUD) and mental health disorders are significant public health issues that co-occur and are associated with high risk for suicide attempts. SUD and mental health disorders are more prevalent among offenders (i.e., prisoners or inmates) than the non-imprisoned population, raising concerns about the risk of self-harm. This cross-sectional study examined the population of a state prison system (10,988 out of 13,079) to identify associations among SUD (alcohol, cannabis, intravenous drugs, narcotics, and tobacco smoking), mental health disorders (anxiety, bipolar, depression, and psychotic disorders), and suicide attempts. The primary aim was to determine which groups (SUD, mental health disorders, and co-occurrences) were strongly association with suicide attempts. Groups with a documented SUD or mental health disorders compared to peers without these issues had 2.0 and 9.2 greater odds, respectively, for attempting suicide, which was significant at p < 0.0001 for both conditions. There were also significant differences within SUD and mental health disorders groups in regard to suicide attempts. Groups with the greatest odds for suicide attempts were offenders with comorbid bipolar comorbid and anxiety, alcohol combined with depression, and cannabis co-occurring with depression. Documentation of suicide attempts during imprisonment indicates awareness, but also suggest a need to continue enhancing screening and evaluating environmental settings.

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“…This may be due to the difficulty in diagnosing bipolar disorder given that the disease encompasses a spectrum of depressive and manic symptoms and screening questionnaires have low specificity [32,34]. In 2007, a population based cohort study performed by Ludvigsson et al found no increased risk of bipolar disorder among 13,776 patients with celiac disease (HR 1.1; 95% CI 0.7-1.7), though they did find an increased risk of celiac disease among patients with pre-existing bipolar disorder (OR 1.7; 95% CI 1.2-2.3) [17].…”

Section: Discussionmentioning

confidence: 99%

Psychotropic Medication Use Among Patients with Celiac Disease

et al. 2017

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Background: Celiac disease is a multi-system disorder with manifestations that may result in psychiatric disorders. We assessed the prevalence of medication use to treat psychiatric disorders in celiac disease patients. Methods: We conducted a cross-sectional study of patients undergoing esophagogastroduodenoscopy over 9-years at a celiac disease referral center. We compared the prevalence of psychotropic medication use among celiac disease patients (n = 1293) to a control group (n = 1401) with abdominal pain or reflux. Results: Among all patients the mean age was 48.4 years, most were female (69.5%), and 22.7% used any psychotropic medication. There was no difference between overall psychotropic medication use among celiac disease patients and controls (23.9% vs 21.8%, OR 1.16; 95% CI 0.96-1.39, p = 0.12). However, those with celiac disease were more likely to use antidepressants on univariate (16.4% vs 13.4%, p = 0.03) and multivariate analysis (OR 1.28; 95% CI 1.03-1.59; p = 0.03). Use of psychotropic medications was not associated with disease duration or mode of presentation of celiac disease. Conclusions: Celiac disease patients use psychotropic medications at similar rates as those with other gastrointestinal diseases, though subgroup analysis suggests they may use more antidepressants. Future studies should investigate whether celiac disease is associated with mood disorders that are not treated with medications.

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Screening for bipolar disorders: A public health issue

Cited by 57 publications

References 47 publications

An evolutionary approach to mania studying Sardinian immigrants to Argentina

An evolutionary approach to mania studying Sardinian immigrants to Argentina

Associations among Substance Use, Mental Health Disorders, and Self-Harm in a Prison Population: Examining Group Risk for Suicide Attempt

Psychotropic Medication Use Among Patients with Celiac Disease

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