Screening for cancers of the cervix and vagina for women exposed to diethylstilbestrol (DES) in utero

Tournaire, Michel; Devouche, Émmanuel; Lafaye, Nathalie; Levadou, Anne

doi:10.1016/j.jogoh.2020.102042

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Tournaire et al. published CCCC screening recommendations for young women exposed to DES in France ( 24 ). The methods suggested the association of cytology and hrHPV testing with cervical and vaginal sampling.…”

Section: Discussionmentioning

confidence: 99%

Clinical and pathological characteristics of cervical clear cell carcinoma in patients not exposed to diethylstilbestrol: a comprehensive analysis of 49 cases

Zeng,

Jiang,

et al. 2024

Front. Oncol.

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PurposeThis study aimed to investigate the clinical and pathological characteristics, treatment strategies, and prognosis of cervical clear cell carcinoma (CCCC) in patients not exposed to diethylstilbestrol in uteroMethodsThe patients diagnosed with CCCC at West China Second University Hospital of Sichuan University between January 2011 and Jun 2023 were enrolled for this retrospective study. The clinical characteristics and information on treatment and follow-up were collected. The Kaplan–Meier method and Cox regression analysis were performed to identify the relative variables for predicting progression-free survival (PFS) and overall survival (OS).ResultsOf the 49 patients included, the Federation International of Gynecology and Obstetrics (FIGO) (2018) stage distribution was 37 (75.5%) stage I, 6 (12.2%) stage II, and 6 (12.2%) stage III. The median follow-up interval was 24.1 months. Six (12.2%) patients had a recurrence, and five (10.2%) patients died. The 5-year PFS rate was 86.8%, and the 5-year OS rate was 88.2%. No recurrence or death was detected in two patients who successfully completed fertility-preserving treatment and seven patients who underwent surgery to preserve ovaries. Two patients became pregnant, giving birth to two babies. The univariate analysis showed that FIGO stage, Pelvic lymph node (PLN) metastasis, lymph vascular space invasion, and depth of stromal invasion (P < 0.05) were significantly associated with PFS and OS. However, no significant prognostic factors were identified in the multivariate analysis.ConclusionOvary-preserving treatment and fertility-preserving surgery are safe and feasible in early-stage CCCC. Surveillance other than adjuvant treatment may be a better choice for early-stage CCCC without any pathological risk factors. More targeted therapies and immunotherapy should be pursued in future studies.

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Section: Discussionmentioning

confidence: 99%

Clinical and pathological characteristics of cervical clear cell carcinoma in patients not exposed to diethylstilbestrol: a comprehensive analysis of 49 cases

Zeng,

Jiang,

et al. 2024

Front. Oncol.

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“…[ 18 ]. A study in France also suggested annual screening of cervix and vagina for these women and that it continues beyond 65-years of age and after hysterectomy with cytological examination [ 19 ]. We would need to tailor the screening program and identify those few individuals with DES exposure to aid in the early detection of cervical and vaginal adenocarcinomas [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Clear Cell Cervical Carcinoma to a Woman, 50 Years After Diethylstilbestrol Exposure for Lactation Suppression

Palaiologos

Theofrastou

Gerovasileiou

et al. 2021

Cureus

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“…DES is a liposoluble compound that easily remains in the animal body; even if it is excreted from the body, it will enter water and soil, leading to a vicious cycle of environmental pollution. Further, eating animal products containing DES residues will also increase the risk of cancer 9 . Recent studies have shown that not only does DES increase the risk of cancer and raise the incidence of myocardial infarction and coronary artery disease, but that the negative effects of DES change with age 6,10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…Further, eating animal products containing DES residues will also increase the risk of cancer. 9 Recent studies have shown that not only does DES increase the risk of cancer and raise the incidence of myocardial infarction and coronary artery disease, but that the negative effects of DES change with age. 6,10,11 Due to its low cost and pharmacological effects, DES continues to be used in clinical practice and animal farming, leading to a vicious cycle of continuous emissions and environmental pollution throughout the year.…”

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confidence: 99%

Interaction between laccase and diethylstilbestrol based on multispectral and chromatography analyses

Lin

Liu

Lin

et al. 2022

J of Molecular Recognition

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Diethylstilbestrol (DES) is a synthetic form of oestrogen that does not easily degrade in the environment and can be harmful to human health. Herein, the mechanism of the interaction between laccase and DES was investigated by various spectroscopic means and high-performance liquid chromatography (HPLC). The results of fluorescence experiments showed that the quenching of intrinsic fluorescence of laccase by DES was due to a static quenching, forming a binding site. According to the Förster non-radiative energy transfer theory (FRET), the action distance R 0 between DES and laccase was 4.708 nm, r was 5.81 nm, and the energy transfer efficiency E was 22.08%, respectively. Both UV-Vis absorption spectra and FT-IR spectra indicated changes in the conformation and surroundings of the enzyme and changed in the secondary structure of laccase. Multispectral synthesis showed that the interaction of laccase with DES caused a change in the secondary structure of laccase. The degradation experiments showed that laccase could degrade DES, and the DES content decreased with time. This study provides a new theoretical basis and experimental method for further research on the reaction mechanism of the laccase degradation of DES. It may also provide a reference basis for human biological and environmental safety evaluations.

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Screening for cancers of the cervix and vagina for women exposed to diethylstilbestrol (DES) in utero

Cited by 6 publications

References 14 publications

Clinical and pathological characteristics of cervical clear cell carcinoma in patients not exposed to diethylstilbestrol: a comprehensive analysis of 49 cases

Clinical and pathological characteristics of cervical clear cell carcinoma in patients not exposed to diethylstilbestrol: a comprehensive analysis of 49 cases

A Rare Case of Clear Cell Cervical Carcinoma to a Woman, 50 Years After Diethylstilbestrol Exposure for Lactation Suppression

Interaction between laccase and diethylstilbestrol based on multispectral and chromatography analyses

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