Screening for Cervical Cancer

Macgregor, J.Elizabeth; Teper, Sue; Melcher, D. H.; Linehan, J.J.

doi:10.1016/s0140-6736(74)91024-1

Cited by 14 publications

(2 citation statements)

References 6 publications

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“…Screening by Pap Smear is more than worth its cost 2 (Macgregor JE, 1982). The original terminology of dysplasia and carcinoma in situ (WHO) classification was replaced by the cervical intraepithelial neoplasia (CIN) terminology.…”

Section: Discussionmentioning

confidence: 99%

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Clinical, Cytological and Histopathological Correlation in Lesions of Uterine Cervix

Parija¹,

Mohapatra²

2017

jemds

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BACKGROUNDCytological screening of the uterine cervix by Papanicolaou test has reduced the incidence of cervical cancer. But cytological diagnosis in clinically suspicious lesions of cervix is provisional and has to be corroborated with histopathological findings for effective treatment response. MATERIALS AND METHODSStudy Design-A descriptive study. Three hundred patients attending Gynaecological Oncology OPD of A.H. Regional Cancer Centre, Cuttack during the period April 2016-March 2017, were studied. History taking, clinical examination was followed by cervical smear and multiple punch biopsies, in patients with unhealthy cervix. The cytological and histopathological results were correlated with each other and clinically. RESULTSClinically, cancer was detected in 77.6% cases. Cytologically, 73.3% reported carcinoma and 3.33% squamous intraepithelial lesions. Histopathologically, 74.6% showed carcinoma and 3.7% SIL. The cytohistopathological agreement was 69.2% in inflammatory lesions and 90.5% in invasive carcinomas. In clinically unhealthy cervix, a report of squamous intraepithelial-lesion by cytology was seen in 17.02% and by histopathology was found in 19.15%. Cytological proof of cancer was obtained in 73.3% of cases and histopathological proof in 74%. On overall analysis of 300 cases of suspicious cervix, 229 correlated well with cytology, labelling them as abnormal and 246 cases were stamped as diseased by histopathology. CONCLUSIONThis study proves that cytology can be used as a very effective screening tool to catch high risk cases, which can be biopsied to detect cancer early. Both cytology and histopathology correlate well with clinically obvious lesions of the cervix.

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Section: Discussionmentioning

confidence: 99%

“…Routine cytological screening of the uterine cervix based on Papanicolaou test, has reportedly reduced the incidence of invasive carcinoma cervix 1&2 (Walton RJ 1976, Macgregor 1982. Cytological diagnosis in clinically suspicious lesion is to be fortified with biopsy and colposcopically directed biopsy, if required.…”

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confidence: 99%

Clinical, Cytological and Histopathological Correlation in Lesions of Uterine Cervix

Parija¹,

Mohapatra²

2017

jemds

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Population cancer screening

Sutnick

Miller

Samson

et al. 1976

Cancer

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Controlled trials to evaluate mass screening programs for cancer detection have been singularly lacking. High cost, lack of medical manpower, and low yield have contributed to this problem. A new program in cancer detection (CANSCREEN) has been developed jointly by The Fox Chase Cancer Center in Philadelphia and the Preventive Medicine Institute in New York City. This program attempts to provide a quality cancer-detection examination with increased cost effectiveness. Features include: 1) a self-administered questionnaire on medical history, symptoms, and risk factors; 2) nonphysican examiners; 3) risk-facotr analysis with a predetermined decision logic to determine type and periodicity of examination; and 4) primary intervention (health education). This collaborative program between two institutions in two cities demonstrates the feasibility of introducing similar programs elsewhere. A data base shared by cooperating centers permits information on all patients to be used for evaluation of new techniques, end results, etc. A randomized controlled trial has been designed to evaluate the effectiveness and efficiency of the questionnaire alone and of the questionnaire and examination.

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Screening high-risk populations: A challenge to primary medical care

Kessner¹

1976

J Community Health

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The organizational, educational, and policy implications of screening high-risk populations are considered for five selected conditions: (a) the role of pregnancy-risk indices for the identification of high-risk women as it relates to the efficient use of perinatal and neonatal intensive care centers; (b) screening school-age children for conductive hearing loss, with emphasis on the role of complete otologic examination, threshold testing, and tympanometry in children with a history of recent or recurrent middle ear disease; (c) the efficacy of Pap smears in reducing mortality from cervical cancer; (d) the current status of clinical examination and mammography for detecting breast cancer; and (e) the problems inherent in diagnosing and treating hypertension. Because of the increasing costs of new technology that have not yet been adequately tested, health professionals bear an increasing obligation to require scientific evidence of the efficacy of the screening procedures before instituting large-scale programs.

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Screening for Cervical Cancer

Cited by 14 publications

References 6 publications

Clinical, Cytological and Histopathological Correlation in Lesions of Uterine Cervix

Clinical, Cytological and Histopathological Correlation in Lesions of Uterine Cervix

Population cancer screening

Screening high-risk populations: A challenge to primary medical care

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