Screening for cervical neoplasia in a developing country utilizing cytology, cervicography and the acetic acid test

Cronjé, H. S.; Cooreman, Bruno; Beyer, E.; Bam, Roosmarie H.; Middlecote, B. D.; Divall, Peter

doi:10.1016/s0020-7292(00)00382-9

Cited by 35 publications

(20 citation statements)

References 14 publications

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“…[7] Regarding socio-demographic data of the study group, it was found that 44% of them ranged from 20-30 years old with mean age 33.7 years. This result was in agreement with Cronje et al, 2001 [10] who reported in their study about screening for cervical neoplasia in a developing country utilizing cytology, cervicography and the acetic acid test that their study sample had a mean age of 34.4 years. It was also in agreement with Dhaubhadel et al (2008) [14] who reported in their study about early detection of cervical cancer precursors of cervical cancer by visual inspection of cervix with acetic Acid that their study sample had a mean age of 31.1 years.…”

Section: Discussionsupporting

confidence: 92%

Accuracy of visual inspection with acetic acid in cervical ectopy evaluation

Sheesha

Mansour

Kheder

et al. 2015

JNEP

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Background: Cervical erosion is one of the most common pathological conditions encountered in outpatient gynecological clinics in middle-aged women. A simple method for diagnosis and treatment can play a tremendous role to comfort these women. Methods: The study includes fifty female patients attended the outpatient clinic of obstetrics & gynecology department in Mansoura University hospitals. All patients selected according to inclusion and exclusion criteria. The study was undertaken during the period from June 2014 to December 2014. Tools: Two tools were used for data collection: (1) Interviewing questionnaire schedule divided into three parts which were used to assess general characteristics of women, obstetric and gynecological history and the presence of cervical ectopy symptoms. (2) Local cervical assessment by vinegar acetic acid (VIA) test. Results: The study results revealed that 30 subjects (60%) were VIA positive and 20 subjects (40%) were VIA negative. VIA sensitivity was 100%, specificity 45%, PPV 71% and NPV 75%. There was a statistically significant relation between duration of marriage, high parity, IUDs use and VIA positivity. Conclusions: Using VIA test was an accurate and effective method for detection of cervical ectopy. VIA test should be performed in all the women attending outpatient gynecological clinics even in the presence of Pap smear facility to improve detection rate of cervical lesions and provide better patient counseling and treatment.

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Section: Discussionsupporting

confidence: 92%

Accuracy of visual inspection with acetic acid in cervical ectopy evaluation

Sheesha

Mansour

Kheder

et al. 2015

JNEP

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“…Some earlier studies have reported VIA sensitivity to be stable with age (Cronje et al, 2001;Sankaranarayanan et al, 2004a), but they suffered from verification bias. In a large study in Guanacaste, Costa Rica, the performance of cervicography, a variant of visual inspection with remote assessment of photographic images of the cervix, was noted to decrease substantially with age (Ferreccio et al, 2003).…”

Section: Discussionmentioning

confidence: 96%

Different cervical cancer screening approaches in a Chinese multicentre study

Shi

Franceschi

et al. 2009

Br J Cancer

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To evaluate alternative cervical cancer screening methods, digital colposcopy and collection of cervical exfoliated cells for liquid-based cytology (LBC) and hybrid capture 2 (HC2) testing were performed among 2562 women aged 15 -59 years in three study sites in the People's Republic of China (rural Shanxi province, Shenyang city in Liaoning province and Shenzhen city in Guangdong province). Visual inspection with acetic acid (VIA) was also evaluated independently from colposcopy. A total of 74 cases of histologically confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2 þ ) were identified, and 16 CIN2 þ cases were imputed among unbiopsied women to correct for verification bias. Corrected sensitivity for CIN2 þ was 37% for VIA, 54% for colposcopy, 87% for LBC with a threshold of atypical cells of undetermined significance (LBCXASCUS), 90% for HC2, 84% for LBC using HC2 to triage ASCUS and 96% for positivity to LBCXASCUS or HC2. For VIA, sensitivity was much lower among women X40 years (12%) than those aged p39 years (50%). Specificity varied from 77% for positivity to LBCXASCUS or HC2, up to 94% for LBC using HC2 to triage ASCUS. In conclusion, LBC, HC2 and their combinations performed well, whereas VIA missed a majority of CIN2 þ , particularly in older women. Digital colposcopy performed better than VIA, but still missed nearly half of CIN2 þ in this study.

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“…The sensitivity and specificity of pap test accuracy ranges from 11 to 99% and 14 to 97% respectively [25][26][27][28].Whereas reports of cytology sensitivity in detecting cervical neoplasia ranged from 50%-98% [28]. It should be borne in mind that the wide range of variation in the performance of pap smear screening regarding sensitivity and specificity as mentioned by the above studies may have some bearing in the outcome from it based on different setup.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Pattern of Cervical Papanicolaou (PAP) Smears: A hospital based experience

Shrestha¹,

Suwal

Gupta³

2018

Janaki Med. Coll. J. Med. Sci.

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Background and Objectives:Cervical cancer is very common type of cancer in women globally. The objective of this study was to compare the cytopathological findings of the cervical pap smears using the revised 2001 Bethesda system and to compare the cytopathological findings with the clinical features. Material and Methods:A total of 1016 pap smear sent to the Department of Cytopathology at Peoples Dental college general hospital (PDCH), Kathmandu over a period of three years were studied. Relevant history and clinical findings were retrieved for the study. The age, caste, location, gravida of the patient, the nature of complaint of patient to the doctor along with the per speculum findings, per vaginal examination findings of the patient and their relation to the cytopathological findings of pap smears were evaluated.Results: No significant relationship was observed between the (30-39 years) aged women and the available outcome of pap smear (p=0.404). Most of the females were Brahmin and Newars. The statistical analysis showed no significant relationship (p>0.05) between the ethnicity and pap smear result. The number of asymptomatic women in this study was found 22.9%. This study found 20.37% of intraepithelial lesion or malignancy. Trichomonas vaginalis and bacterial vaginosis combinely contributed to 0.7% of the total cases in this study. Three smear cases were detected having malignant epithelial cell which were diagnosed with adenocarcinoma, squamous cell carcinoma. Conclusion:In this study cervical pap smear was able to differentiate inflammatory, benign precursors and malignant cases. So, it is desirable to conduct routine Pap smear screening in women of all reproductive age regardless of race, ethnic background and socioeconomic status.

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Screening for cervical neoplasia in a developing country utilizing cytology, cervicography and the acetic acid test

Cited by 35 publications

References 14 publications

Accuracy of visual inspection with acetic acid in cervical ectopy evaluation

Accuracy of visual inspection with acetic acid in cervical ectopy evaluation

Different cervical cancer screening approaches in a Chinese multicentre study

Clinicopathological Pattern of Cervical Papanicolaou (PAP) Smears: A hospital based experience

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