Screening for diabetes

Davies, Melanie J.; Day, John

doi:10.1136/bmj.308.6937.1160b

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…A critical factor in determining the utility of a programme at population level is the relative benefit to those who are detected and treated, compared to the harm caused by labelling and unnecessary treatment of those who are actually false positives. [15][16][17] Screening programmes for diabetes usually consist of a screening test-for example, a questionnaire, [18][19][20] or test for glycosuria, [21][22][23] followed by a confirmatory diagnostic test. 24 The current accepted diagnostic test (World Health Organization 1985) is the standard 75 g oral glucose tolerance test (OGTT).…”

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confidence: 99%

The effect of varying the screening interval on false positives and duration of undiagnosed disease in a screening programme for type 2 diabetes

et al. 2000

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Objectives-The aims of this study were to quantify the proportion of people diagnosed as having type 2 diabetes by standard 75 g oral glucose tolerance test, in a hypothetical screening programme, who would actually be false positives (false positive percentage), and the eVect on the false positive percentage of varying the time between repeat screens. We also calculated the duration in person years of exposure to undiagnosed disease in the population for each screening interval. Setting-Ely, Cambridgeshire, UK. Methods-We used the glucose tolerance data from 965 participants of the Ely Diabetes Project, who were tested 4.5 years apart, to calculate the population's between and within person variance for 2 hour plasma glucose, and constructed a probability matrix of observed v true glucose tolerance categories. The progression of the population between glucose tolerance categories was modelled assuming exponential times to progression. Results-After one year, 47.5% of test positives were disease free: almost half of those labelled with diabetes would not have the disease. For a 5 year interval, the false positive percentage was 27.6%, but the population would have been exposed to undiagnosed diabetes for 144 person years. Conclusions-Screening can be associated with both benefit and harm; the balance is dependent on characteristics of the disease and the screening programme. This study has quantified the trade oV between exposure to undiagnosed diabetes and false positive results to inform the debate about screening for type 2 diabetes. (J Med Screen 2000;7:91-96)

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confidence: 99%

The effect of varying the screening interval on false positives and duration of undiagnosed disease in a screening programme for type 2 diabetes

et al. 2000

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“…Early detection of non-insulin dependent diabetes by screening seems promising in terms of reduced morbidity and cost effectiveness 17. However, we will need to prove this unequivocally by large (and expensive) studies which are unlikely to be funded by the pharmaceutical industry.…”

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confidence: 99%

Science, medicine, and the future Non-insulin dependent diabetes mellitus: the gathering storm

O'Rahilly

1997

BMJ

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Characteristics of Registered Diabetics in Dhank Province in the Sultanate of Oman

Al-Rubaee¹,

Al-Abri²

2016

Oman Med J

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Screening for diabetes

Cited by 3 publications

References 2 publications

The effect of varying the screening interval on false positives and duration of undiagnosed disease in a screening programme for type 2 diabetes

The effect of varying the screening interval on false positives and duration of undiagnosed disease in a screening programme for type 2 diabetes

Science, medicine, and the future Non-insulin dependent diabetes mellitus: the gathering storm

Characteristics of Registered Diabetics in Dhank Province in the Sultanate of Oman

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