Screening for Early Dementia Using Memory Complaints From Patients and Relatives

McGlone, Jeannette; Gupta, Shalini; Humphrey, Diane; Oppenheimer, Stephen; Mirsen, Tom; Evans, David R.

doi:10.1001/archneur.1990.00530110043015

Cited by 141 publications

(112 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested that caregiver assessment of memory impairment is more meaningful than the subjects' own assessments, 51 and that caregivers can accurately detect subtle impairment before measurable neuropsychological deficits are evident. 8,53 Caregiver report of memory decline with an impact on function over the previous 12 months has previously been found to predict the development of dementia.…”

Section: Discussionmentioning

confidence: 99%

“…16 Relatives' report of memory deterioration also appears to accurately detect mild cognitive impairment even in the absence of measurable neuropsychological deficits. 8,[51][52][53] It is not clear that new neuropsychological subtypings of MCI lead to any increase in predictive ability. 54 There is growing evidence that signs and symptoms of vascular disease are important risks for dementia, and even for AD.…”

Section: Clinical Risk Factors For Development Of Dementia and Admentioning

confidence: 99%

See 1 more Smart Citation

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Fellows

Bergman²,

Wolfson³

et al. 2008

Can. j. neurol. sci.

View full text Add to dashboard Cite

314As treatments to alleviate symptoms and to slow the progression of Alzheimer's disease (AD) emerge, an increasingly urgent dilemma for physicians is also developing: which of the many elderly individuals with memory complaints will develop Alzheimer's disease, and would therefore be candidates for preventive therapies? An important goal of current research must be to establish useful pre-clinical diagnostic and predictive guidelines, and this can only emerge from longitudinal follow-up of elderly individuals with mild memory loss. In this paper, we report the clinical characteristics of such a group, with the aim of ABSTRACT: Background: To determine whether clinical data obtained by history and physical examination can predict eventual progression to dementia in a cohort of elderly people with mild cognitive impairment. Methods: A prospective, longitudinal study of a cohort of elderly subjects with amnestic Mild Cognitive Impairment (MCI). Ninety subjects meeting the criteria for amnestic MCI were recruited and followed annually for an average of 3.3 years. Main outcome measure was the development of dementia determined by clinical assessment with confirmatory neuropsychological evaluation. Results: Fifty patients (56%) developed dementia on follow-up. They were older, had lower Mini-mental status exam (MMSE) scores and a shorter duration of symptoms at the time of first assessment. Multivariate logistic regression analysis identified age at symptom onset as the only clinical parameter which distinguished the group that deteriorated to dementia from the group that did not. The odds ratio for age was 1.1 (confidence interval 1.04 -1.18). Conclusions: Patients presenting with amnestic MCI insufficient for the diagnosis of dementia are at high risk of developing dementia on follow-up. In our cohort, 56% were diagnosed with dementia over an average period of 5.9 years from symptom onset. The only clinical predictor for the eventual development of dementia was older age at symptom onset. Clinical features alone were insufficient to predict development of dementia.RÉSUMÉ: Les données cliniques peuvent-elles prédire la progression vers la démence dans l'atteinte cognitive légère avec syndrome amnésique? Contexte : Le but de cette étude était de déterminer si les données cliniques provenant de l'histoire médicale et de l'examen physique peuvent prédire la progression éventuelle vers la démence dans une cohorte de gens âgés ayant une atteinte cognitive légère. Méthodes : Il s'agit d'une étude longitudinale prospective d'une cohorte de sujets âgés ayant une atteinte cognitive légère (ACL). Quatre-vingt-dix sujets rencontrant les critères diagnostiques de l'ACL amnésique ont été recrutés et suivis annuellement pendant 3,3 ans en moyenne. Le critère d'évaluation principal était l'apparition d'une démence selon l'évaluation clinique confirmée par une évaluation neuropsychologique. Résultats : Cinquante patients (56%) ont développé une démence au cours du suivi. Ils étaient plus âgés, avaient des scores MMSE plus bas et u...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Clinical Risk Factors For Development Of Dementia and Admentioning

confidence: 99%

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Fellows

Bergman²,

Wolfson³

et al. 2008

Can. j. neurol. sci.

View full text Add to dashboard Cite

show abstract

“…62 Studies have shown that cognitive decline is associated with increased morbidity and mortality. [63][64][65] Cognitive decline also can affect quality of life and independence. Other factors that might cause mental status changes and cognitive decline include depression, diabetes mellitus, infection, pain, and drug use or misuse.…”

Section: Sensory and Memory Deficitsmentioning

confidence: 99%

Pharmacy Practice, Research, Education, and Advocacy for Older Adults

et al. 2005

View full text Add to dashboard Cite

In the United States, older adults have become the fastest growing segment of the population and are expected to double in number to 70 million by 2030. As a whole, older adults have different health care needs than younger patients, and some of these needs should be met by pharmacists. Clinical pharmacy practice affecting older adults occurs in a variety of settings, including community, ambulatory care, primary care, hospital, assisted living, nursing home, home health care, hospice, and Alzheimer's disease units. Although specialty training in geriatrics or gerontology is not required for pharmacists to care for older adults, it is extremely helpful. Pharmacy education related to the care of older adults has improved slightly in the past several years but will need to increase even more to provide all pharmacists with the basic skills and knowledge to care for this unique group of patients. In addition, pharmacotherapy research targeting older adults needs to increase. Although it can be challenging, funding for this type of research is available. Patient and political advocacy is also important to support this growing population.

show abstract

“…Carers' complaints about the memory of their relatives correlate with dementia (II). [8][9][10][11][12] Recommendations and important points x Insight diminishes as dementia progresses making the patient's history less reliable (B).…”

Section: Statementsmentioning

confidence: 99%

North of England evidence based guidelines development project: guideline for the primary care management of dementia

1998

BMJ

View full text Add to dashboard Cite

Screening for Early Dementia Using Memory Complaints From Patients and Relatives

Cited by 141 publications

References 15 publications

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Pharmacy Practice, Research, Education, and Advocacy for Older Adults

North of England evidence based guidelines development project: guideline for the primary care management of dementia

Contact Info

Product

Resources

About