Screening for Elevated Lead Levels in Childhood and Pregnancy: An Updated Summary of Evidence for the US Preventive Services Task Force

Rischitelli, Gary; Nygren, Peggy; Bougatsos, Christina; Freeman, Michele; Helfand, Mark

doi:10.1542/peds.2006-2284

Cited by 31 publications

(27 citation statements)

References 91 publications

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“…Previous studies in this area have shown that the DMSA has a notable specificity to lead in humans. In addition, a clinical trial has evidenced that this antidote is able to induce a shortterm reduction of blood levels in children exposed to lead, but there was no evidence of it being beneficial on health outcome (Rischitelli et al, 2006).…”

Section: Dmsa -Succimermentioning

confidence: 99%

Molecular mechanisms triggered by mercury

Guzzi¹,

2008

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Section: Dmsa -Succimermentioning

confidence: 99%

Molecular mechanisms triggered by mercury

Guzzi¹,

2008

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“…A 2006 United States Preventative Services Task Force concluded that there was no persuasive evidence that screening asymptomatic children would lead to improved clinical outcomes. 25 Yet there continues to be increasing evidence of the negative health outcomes associated with BLLs <10 mg/dL solidifying for many that there is no safe BLL and reinforcing the importance appropriate screening methods and guidelines. [26][27][28][29] Although targeted screening strategies have been developed, 30,31 they have been employed with limited success.…”

Section: Discussionmentioning

confidence: 99%

Barriers to Pediatric Lead Screening: Implications From a Web-Based Survey of Vermont Pediatricians

Keeshan

Avener

Abramson

et al. 2010

Clin Pediatr (Phila)

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The pernicious effects of lead on child health are well documented. The Vermont Department of Health (VDH) recommends screening all 12-and 24-month-old children for elevated blood lead levels (BLL). In 2006, only 41.4% of 24-month-old Vermont children were screened. To identify barriers preventing pediatricians from performing blood lead screening, a survey was distributed to Vermont primary care pediatricians-divided in higher and lower screening groups. Vermont pediatricians were more likely to be lower screeners if they reported negative health outcomes began at BLL > 10 mg/dL (odds ratio [OR] = 3.64, 95% confidence interval [CI] = 1.12-11.99), practiced in Chittenden County (OR = 3.34, 95% CI = 1.14-9.78), or disagreed with the VDH's recommendation (OR = 4.90, 95% CI = 1.66-15.50). Adjusted analysis indicated the most significant determinants of lower screening rates were male gender, a perceived dangerous BLL as >10 mg/dL and low self-reported Medicaid population. The VDH may have an opportunity to increase BLL screening emphasizing the significant health risks associated with BLL ≤ 10 mg/dL.

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“…Clinical testing for blood lead levels (BLL) in the region is sporadic, despite calls from experts over the past decade to increase BLL testing and test data sharing (Keyser et al, 2006 (Hopey, 2017b;Rischitelli et al, 2006). Lead testing does not reveal the source of lead contamination (e.g., water, paint, soil), but can help to direct mitigation efforts via targeted assessments in residences of children with high BLL and prioritizing lead remediation resources for those households.…”

Section: Why Has Lead In Water Re-emerged As An Urgent Policy Concern?mentioning

confidence: 99%