Screening for hemoglobin disorders in Thai pregnant women by England and Frazer's calculation method

Abstract

England and Frazer's calculation method can be an alternative method that can help screen for hemoglobin E disorders in pregnant women.

Feasibility of four discriminant functions for identifying hemoglobin E disorders: Experience in 114 Thai pregnant subjects

“…According to our previous study using England and Frazer's calculation method in screening for Hb disorders in Thai pregnant subjects, good diagnostic properties were determined [3]. Recently, Ittarat et al [4] proposed the possibility of using some modified discriminant functions (DFs) as alternative tools for screening for such disorders among the general population. However, these DFs were originally primarily applied to the differentiation of iron deficiency anemia from betathalassemia.…”

“…The functions evaluated were: a) F1=0.01xMCH X(MCV)2, b) F2=RDWxMCHx (MCV)2/ Hbx100, c) F3=MCV/RBC, and d) F4= MCH/RBC. The correlation between DFs and HbE was evaluated according to the previous published method of Ittarat et al [4]. DFs demonstrating a significant difference in distinguishing Hb disorders were selected for further evaluation of diagnostic properties (sensitivity, specificity, and false positive and false negative values).…”