1999
DOI: 10.1159/000028063
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Screening for Invasion of the Individual Human Brain Tumour in an Autologous Confrontation System in vitro

Abstract: Invasiveness is the major cause of death in patients bearing a brain tumour. The invasiveness or infiltrative capacity of a primary brain tumour has a prognostic value for the evaluation of the process in vivo. So a model to imitate invasion might give information on the in vivo behaviour and outcome of the disease for the individual patient. The developed in vitro model represents an assay in which the patients’ brain tumour-derived cells are confronted with connective tissue from the patient himself, i.e. an… Show more

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Cited by 7 publications
(3 citation statements)
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“…Overall, the invasiveness results obtained by confrontation assay are correlated with malignancy in vivo [256]. Moreover, this assay is also suitable for study of the involvement of specific genes, for testing various anti-tumoral molecules/drugs or the effect of radiotherapy on brain tumor invasion ability [250,257,258].…”
Section: D Models For Testing Motility/invasion Of Cns Tumorsmentioning
confidence: 94%
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“…Overall, the invasiveness results obtained by confrontation assay are correlated with malignancy in vivo [256]. Moreover, this assay is also suitable for study of the involvement of specific genes, for testing various anti-tumoral molecules/drugs or the effect of radiotherapy on brain tumor invasion ability [250,257,258].…”
Section: D Models For Testing Motility/invasion Of Cns Tumorsmentioning
confidence: 94%
“…In this case, neurospheres are placed in contact with normal tissues, which are used as the target tissues that may be invaded and destroyed by invading neoplastic cells [247]. Either embryonic chick tissue, foetal brain aggregate (heterologous), or normal connective tissue from the tumor-bearing patient (autologous) [240,242,[248][249][250][251] have been used as the target tissues.…”
Section: D Models For Testing Motility/invasion Of Cns Tumorsmentioning
confidence: 99%
“…32 Over the years, several attempts have been made to design reliable methods to evaluate the invasiveness of gliomas that have been removed at biopsy. 9,16,20,40 Investigations of monolayer migration 9,20,28 and filter-based transmigration, 43 as well as studies in which glioma spheroids are confronted with various invasion substrates, 13,15,16,40 have highlighted isolated aspects of glioma cell motility and invasiveness. 32,47 None of these methods combines technical simplicity, reliability, and precision of the estimate.…”
mentioning
confidence: 99%