Introduction: Vaginal Discharge is most common distressing symptoms in women. But there is social implication and embarrassment of women in front of families and society, lack of knowledge, illiteracy and superstitious belief makes under treatment of disease. Syndromic approach makes adequate and timely management of disease. Material and Method: Study of 300 women with complain of white discharge per vaginum who attending Gynaecology OPD at tertiary care hospital, Mumbai for period of 1year. Study of discharge done by Gram staining and wet mount method under microscope and treated by syndromic approach under WHO guideline. Result: Among 300 cases Bacterial Vaginosis most common followed by candidiasis followed by Bacterial Vaginosis with candidiasis. Conclusion: Contraception, sex education & behavioral changes plays major role in improving the sexual health & thereby avoiding grave consequences therewith.