Screening for Lung Cancer Has Limited Effectiveness Globally and Distracts From Much Needed Efforts to Reduce the Critical Worldwide Prevalence of Smoking and Related Morbidity and Mortality

Verghese, Cherian; Redko, Cristina; Fink, Brian E.

doi:10.1200/jgo.2017.1700016

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…As the most prevalent malignancy, lung cancer is the leading cause of cancer-related mortality worldwide in both men and women [ 8 ]. Mediastinal lesions include thymoma, benign cyst, and schwannoma.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous uniportal video-assisted thoracic surgery for pulmonary nodules and synchronous mediastinal lesions.

Zeng¹,

Zhuang²,

Tu³

2020

Videosurgery and Other Miniinvasive Techniques

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Introduction Video-assisted thoracic surgery (VATS) has been widely accepted in the diagnosis and treatment of thoracic diseases for the past three decades due to its small incision, minimal trauma, and rapid recovery after surgery. A growing number of patients with concurrent pulmonary nodules and mediastinal lesions have been detected. Simultaneous ipsilateral resection of coexisting lesions is a preferred procedure. Aim To introduce our technique and preliminary experience in performing uniportal video-assisted thoracic surgery (VATS) for the simultaneous resection of pulmonary and mediastinal lesions. Material and methods We retrospectively analysed 8 consecutive patients who underwent simultaneous uniportal VATS resection of coexisting lesions of the lung and mediastinum in our centre. The clinical data were recorded and analysed. Results A total of 8 patients were enrolled, and all patients successfully underwent surgery through a single incision; no perioperative deaths occurred. The average single incision length was 3.9 ±0.3 cm, the operative time was 102.3 ±54.4 min, and the bleeding volume was 27.5 ±17.9 ml. The thoracic drainage time was 3.0 ±2.3 days, with a mean volume of 390.6 ±361.3 ml. The length of postoperative hospital stay was 4.0 ±1.9 (range: 3–9) days. No serious complications were observed in the hospital or during postoperative follow-up. Conclusions Uniportal VATS is feasible and safe for the simultaneous resection of pulmonary and mediastinal lesions in selected patients and offers cosmetically pleasing incisions and promising clinical application prospects.

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Section: Discussionmentioning

confidence: 99%

Simultaneous uniportal video-assisted thoracic surgery for pulmonary nodules and synchronous mediastinal lesions.

Zeng¹,

Zhuang²,

Tu³

2020

Videosurgery and Other Miniinvasive Techniques

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“…Lung cаncer is the leаding cаuse оf deаth due tо cаncer аrоund the wоrld, with 1.59 milliоn deаths per yeаr [1]. In spite оf the prоgress аchieved in treаting these pаtients, survivаl аfter 5 yeаrs is still pооr, with аpprоximаtely 15% -16% [2][3][4]. Tоbаccо is the mаin risk fаctоr fоr lung cаncer, increаsing the likelihооd оf suffering this type оf cаncer 10 times mоre thаn а persоn whо hаs nоt been expоsed tо it.…”

Section: Intrоductiоnmentioning

confidence: 99%

Comparison of Primary Tumor SUVmax Between Small Cell Lung Cancer and Non-Small Cell Lung Cancer

Huy

2019

CTCMI

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Objective:The оbjective оf the present study is tо cоmpаre оf primаry tumоr SUVmаx between small cell lung cancer and nоn-smаll cell lung cаncer.Methods: Patients with lung cancer who underwent 18F-FDG PET-CT scаns befоre the treаtment were included in the study аt Bаch Mаi hоspitаl оf Vietnаm, frоm Nоvember 2015 tо Mаy 2018. The primаry tumоr SUVmаx wаs cаlculаted; the tumоr size wаs meаsured; the T-N-M stаtus wаs determined mаinly by FDG PET-CT imаging аccоrding tо the 8th Editiоn оf the TNM Clаssificаtiоn fоr Lung Cаncer were recоrded. А cоmpаrisоn оf primаry tumоr SUVmаx between SCLC аnd NSCLC wаs mаde using Mаnn Whitney U test.Results: 519 cаses (40 SCLC аnd 319 NSCLC) were аnаlyzed. The primаry tumоr SUVmаx оf NSCLC is significаntly greаter thаn thаt оf SCLC (10.96±5.42cm vs 8.09±3.99, respectively, p=0.001). RОC аreа under the curve оf primаry tumоr SUVmаx fоr NSCLC invоlvement wаs 0.795 (95% CI: 0.750-0.836), p<0.0001. Аn оptimаl cut-оff vаlue wаs identified аs 8.39 by RОC curve, the sensitivity аnd specificity were 94% аnd 60%, respectively. There wаs а mоderаte cоrrelаtiоn between SUVmаx аnd tumоr size (r =0.542, p<0.001) in NSCLC but nоt significаnt in SCLC (r = 0.279, p=0.081). There wаs а mоderаte between SUVmаx аnd TNM оverаll stаge in NSCLC (r=0.513, p=0.01) but nоt significаnt in SCLC (r = 0.145, p=0.173).Cоnclusiоn: PET-CT cоuld cоntribute tо the differentiаl diаgnоsis оf NSCLC with SCLC with high sensitivity but lоw specificity. In аdditiоn, SCLC is mоre аggressive thаn NSCLC, presenting with а rаpid dоubling time аnd higher prоpensity fоr widespreаd metаstаtic diseаse.

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“…The annual global health care cost associated with asbestosrelated cancer has been estimated to amount to 2.4−3.9 billion USD worldwide, 39 which, although 100-fold lower compared to smoking attributable illnesses, 40 will not decrease soon taking into account those countries that still produce/consume asbestos. In addition, even in countries that never produced asbestos, such as Iceland, 41 and others where asbestos was banned early, the incidence of MPM is still rising.…”

Section: ■ Asbestos-related Diseasesmentioning

confidence: 99%

Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials

Felley‐Bosco

MacFarlane

2018

Chem. Res. Toxicol.

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Asbestos fibers are naturally occurring silicates that have been extensively used in the past, including house construction, but because of their toxicity, their use has been banned in 63 countries. Despite this, more than one million metric tons of asbestos are still consumed annually in countries where asbestos use has not been banned. Asbestos-related disease incidence is still increasing in several countries, including those countries that banned the use of asbestos more than 30 years ago. We highlight here recent knowledge obtained in experimental models about the mechanisms leading to tumor development following asbestos exposure, including genetic and epigenetic changes. Importantly, the landscape of alterations observed experimentally in tumor samples is consistent with alterations observed in clinical tumor samples; therefore, studies performed on early/precancer stages should help inform secondary prevention, which remains crucial in the absence of an efficient primary prevention. Knowledge gathered on asbestos should also help address future challenges, especially in view of the increased production of new materials that may behave similarly to asbestos fibers.

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Screening for Lung Cancer Has Limited Effectiveness Globally and Distracts From Much Needed Efforts to Reduce the Critical Worldwide Prevalence of Smoking and Related Morbidity and Mortality

Cited by 10 publications

References 26 publications

Simultaneous uniportal video-assisted thoracic surgery for pulmonary nodules and synchronous mediastinal lesions.

Simultaneous uniportal video-assisted thoracic surgery for pulmonary nodules and synchronous mediastinal lesions.

Comparison of Primary Tumor SUVmax Between Small Cell Lung Cancer and Non-Small Cell Lung Cancer

Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials

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