Screening for metabolites from Penicillium novae-zeelandiae displaying radical-scavenging activity and oxidative mutagenicity: isolation of gentisyl alcohol

Alfaro, Cristina; Urios, Amparo; González, M. C.; Moya, Pilar; Blanco, Manuel

doi:10.1016/s1383-5718(03)00166-9

Cited by 32 publications

(27 citation statements)

References 23 publications

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“…It is described as effective and recommended in preference to other dressings for the same purpose, as unripe papaya, in other countries [15]. Physicians from this Hospital described the following advantages of using the papain in comparison with green papaya: dislodging of wounds, promotion of granulation tissue and healing, cost-effectiveness, standardized procedure, facility in its availability, preparing, and application [36]. …”

Section: Discussionmentioning

confidence: 99%

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Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papayaL.) Using In Vitro Assays

Silva

Oliveira

Motta

et al. 2010

Journal of Biomedicine and Biotechnology

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Papain, a phytotherapeutic agent, has been used in the treatment of eschars and as a debriding chemical agent to remove damaged or necrotic tissue of pressure ulcers and gangrene. Its benefits in these treatments are deemed effective, since more than 5000 patients, at the public university hospital at Rio de Janeiro, Brazil, have undergone papain treatment and presented satisfactory results. Despite its extensive use, there is little information about toxic and mutagenic properties of papain. This work evaluated the toxic and mutagenic potential of papain and its potential antioxidant activity against induced-H2O2 oxidative stress in Escherichia coli strains. Cytotoxicity assay, Growth inhibition test, WP2-Mutoxitest and Plasmid-DNA treatment, and agarose gel electrophoresis were used to investigate if papain would present any toxic or mutagenic potential as well as if papain would display antioxidant properties. Papain exhibited negative results for all tests. This agent presented an activity protecting cells against H2O2-induced mutagenesis.

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Section: Discussionmentioning

confidence: 99%

“…The impregnated paper discs were placed on the center of plates and all plates were incubated overnight at 37°C. Inhibition halos were measured (in mm) and expressed after calculating the difference between the inhibition zone diameter and the disc diameter [36]. …”

Section: Methodsmentioning

confidence: 99%

Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papayaL.) Using In Vitro Assays

Silva

Oliveira

Motta

et al. 2010

Journal of Biomedicine and Biotechnology

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“…Patulin (127) has been found in several fungi: Penicilium spp. [126][127][128], Aspergillus spp. [129] and Byssochlamys spp.…”

Section: Oxygen Heterocycle and Benzo Compoundsmentioning

confidence: 99%

“…Compound 178 showed a nematicidal activity to the root-lesion nematode P. penetrans, capable of killing 77% of the nematode at a concentration of 300 mg L -1 [127]. It was suggested that the alkyne carbons likely play an important role in the nematicidal activities of this group of compounds [180,181].…”

Section: Simple Aromatic Compoundsmentioning

confidence: 99%

Nematicidal Substances from Fungi

Zhang²,

Xu³

et al. 2007

BIOT

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This review summarizes the 179 compounds from fungi that have shown to possess nematicidal activities. These compounds belong to diverse chemical groups and they are mainly isolated from a variety of deuteromycete, ascomycete and basidiomycete fungi. Some of them have been patented as nematicidal agents. We review and classify these compounds based on their structural types. Their nematicidal activities are described and their potential roles in natural environments and in the biocontrol of nematodes are discussed.

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“…5). Although there are reports on the antibacterial and antioxidant activities of gentisyl alcohol [25,75,77,79,80,81], there are no reports on its antifungal activity. Therefore, to the best of our knowledge, the present study is the first of its kind reporting the production of antifungal gentisyl alcohol by an endophyte.…”

Section: Pirg Percentage Inhibition In Radial Growthmentioning

confidence: 99%

Production of Gentisyl Alcohol from Phoma herbarum Endophytic in Curcuma longa L. and Its Antagonistic Activity Towards Leaf Spot Pathogen Colletotrichum gloeosporioides

Gupta

Kaul

Singh

et al. 2016

Appl Biochem Biotechnol

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Endophytes from medicinal plants represent a potential source of bioactive compounds. During the present investigation, fungal endophytes were isolated from turmeric (Curcuma longa), an important medicinal plant. A total of 207 endophytic fungal isolates were obtained from the rhizome of C. longa L. They were grouped into seven genera based on morphological and molecular data. The fungal endophytes of C. longa were evaluated for antifungal activity against Colletotrichum gloeosporioides, the causal organism of leaf spot of turmeric. The disease is a major cause for economic loss in turmeric cultivation. Endophytic Phoma herbarum showed significant activity against C. gloeosporioides and was therefore selected for further studies. A compound gentisyl alcohol was isolated from P. herbarum which showed effective antagonism against C. gloeosporioides. The organism could therefore be used as a biocontrol agent against C. gloeosporioides.

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Screening for metabolites from Penicillium novae-zeelandiae displaying radical-scavenging activity and oxidative mutagenicity: isolation of gentisyl alcohol

Cited by 32 publications

References 23 publications

Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papayaL.) Using In Vitro Assays

Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papayaL.) Using In Vitro Assays

Nematicidal Substances from Fungi

Production of Gentisyl Alcohol from Phoma herbarum Endophytic in Curcuma longa L. and Its Antagonistic Activity Towards Leaf Spot Pathogen Colletotrichum gloeosporioides

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