Screening for Nipah Virus Infection in West Kalimantan Province, Indonesia

Sendow, Indrawati; Field, Hume; Adjid, Abdul R M; Ratnawati, Atik; Breed, A. C.; Darminto, Darminto; Morrissy, Chris; Daniels, Peter

doi:10.1111/j.1863-2378.2009.01252.x

Cited by 34 publications

(27 citation statements)

References 24 publications

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“…Nipah virus has been detected in Pteropid fruit bats in Malaysia, Cambodia, and Thailand by serologic analysis, virus isolation, or RNA amplification,24,26,58 and NiV antibodies have also been detected in fruit bats in Indonesia,25 providing evidence that NiV is endemic to Southeast Asia. The most human cases and deaths of any outbreak to date occurred during the outbreaks in Malaysia and Singapore in 1999, and pigs were the source of human infections, demonstrating the importance of pigs as an intermediary amplification host.…”

Section: Discussionmentioning

confidence: 99%

Serologic Study of Pig-Associated Viral Zoonoses in Laos

Conlan¹,

Vongxay²,

Jarman³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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We conducted a serologic survey of four high-priority pig-associated viral zoonoses, Japanese encephalitis virus (JEV), hepatitis E virus (HEV), Nipah virus (NiV), and swine influenza virus (SIV), in Laos. We collected blood from pigs at slaughter during May 2008–January 2009 in four northern provinces. Japanese encephalitis virus hemagglutination inhibition seroprevalence was 74.7% (95% confidence interval [CI] = 71.5–77.9%), JEV IgM seroprevalence was 2.3% (95% CI = 1.2–3.2%), and HEV seroprevalence was 21.1% (95% CI = 18.1–24.0%). Antibodies to SIV were detected in 1.8% (95% CI = 0.8–2.8%) of pigs by screening enzyme-linked immunosorbent assay, and only subtype H3N2 was detected by hemagglutination inhibition in two animals with an inconclusive enzyme-linked immunosorbent assay result. No NiV antibody–positive pigs were detected. Our evidence indicates that peak JEV and HEV transmission coincides with the start of the monsoonal wet season and poses the greatest risk for human infection.

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Section: Discussionmentioning

confidence: 99%

Serologic Study of Pig-Associated Viral Zoonoses in Laos

Conlan¹,

Vongxay²,

Jarman³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…Epidemiological studies demonstrate that Hendra and/or Nipah virus-seropositive fruit bats are widely distributed throughout Asian countries [7-11]. No human cases of henipavirus infection have been reported in Indonesia, although Pteropus vampyrus that are seropositive for both Nipah virus and Hendra virus are distributed nationwide [12,13]. These findings indicate the presence of henipavirus or henipa-like viruses in Indonesian fruit bats, suggesting the need for further epidemiological investigations.…”

Section: Introductionmentioning

confidence: 99%

Molecular detection of a novel paramyxovirus in fruit bats from Indonesia

Sasaki

Setiyono

Handharyani

et al. 2012

Virol J

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BackgroundFruit bats are known to harbor zoonotic paramyxoviruses including Nipah, Hendra, and Menangle viruses. The aim of this study was to detect the presence of paramyxovirus RNA in fruit bats from Indonesia.MethodsRNA samples were obtained from the spleens of 110 fruit bats collected from four locations in Indonesia. All samples were screened by semi-nested broad spectrum reverse transcription PCR targeting the paramyxovirus polymerase (L) genes.ResultsSemi-nested reverse transcription PCR detected five previously unidentified paramyxoviruses from six fruit bats. Phylogenetic analysis showed that these virus sequences were related to henipavirus or rubulavirus.ConclusionsThis study indicates the presence of novel paramyxoviruses among fruit bat populations in Indonesia.

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“…While outbreaks of HeV and NiV have been contained to Australia (HeV) and Malaysia, Bangladesh and India (NiV), additional serological and limited nucleic acid evidence suggests that antigenically related henipaviruses are circulating in other regions including Thailand, Indonesia, China, Madagascar and West Africa [28,29,30,31,32,33,34]. Further serological evidence (cross-reactive antibodies to NiV glycoproteins) has also suggested that henipavirus transmission to domestic pigs in West Africa is possible [35].…”

Section: Introductionmentioning

confidence: 99%

Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics

Steffen

Nikolov

et al. 2012

Viruses

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The Paramyxoviridae genus Henipavirus is presently represented by the type species Hendra and Nipah viruses which are both recently emerged zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in Australia, Southeast Asia, India and Bangladesh. These enveloped viruses bind and enter host target cells through the coordinated activities of their attachment (G) and class I fusion (F) envelope glycoproteins. The henipavirus G glycoprotein interacts with host cellular B class ephrins, triggering conformational alterations in G that lead to the activation of the F glycoprotein, which facilitates the membrane fusion process. Using the recently published structures of HeV-G and NiV-G and other paramyxovirus glycoproteins, we review the features of the henipavirus envelope glycoproteins that appear essential for mediating the viral fusion process, including receptor binding, G-F interaction, F activation, with an emphasis on G and the mutations that disrupt viral infectivity. Finally, recent candidate therapeutics for henipavirus-mediated disease are summarized in light of their ability to inhibit HeV and NiV entry by targeting their G and F glycoproteins.

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Screening for Nipah Virus Infection in West Kalimantan Province, Indonesia

Cited by 34 publications

References 24 publications

Serologic Study of Pig-Associated Viral Zoonoses in Laos

Serologic Study of Pig-Associated Viral Zoonoses in Laos

Molecular detection of a novel paramyxovirus in fruit bats from Indonesia

Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics

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