Screening for Ovarian Cancer: Recommendation Statement

Force, U.S. Preventive Services Task

doi:10.1370/afm.200

Cited by 66 publications

(18 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study reinforces current USPSTF guidelines6 that screening for ovarian cancer is not recommended with annual transvaginal ultrasound or CA125 in women of average risk. It remains to be seen whether screening will impact mortality.…”

Section: Ovarian Cancer Screeningsupporting

confidence: 85%

Update in Women’s Health for the General Internist

et al. 2010

View full text Add to dashboard Cite

Section: Ovarian Cancer Screeningsupporting

confidence: 85%

Update in Women’s Health for the General Internist

et al. 2010

View full text Add to dashboard Cite

“…Moreover, since one of the primary reasons for bilateral oophorectomy is ovarian cancer prophylaxis, patients must weigh the risk of fracture against the risk of ovarian cancer which, over a lifetime for women at average risk, is about 1.4% (26). It is important to note that while there is no accurate screening test for ovarian cancer and the harms of screening for it in average-risk women outweigh the benefits (27), assessment of bone density is predictive of fracture risk in postmenopausal women and, thus, screening for osteoporosis is recommended for all women aged 65 and older (28). Furthermore, there is effective treatment for osteoporosis and for prevention of osteoporotic fracture (29; 30).…”

Section: Discussionmentioning

confidence: 99%

Surgical menopause and nonvertebral fracture risk among older US women

et al. 2012

View full text Add to dashboard Cite

Objective To determine whether older postmenopausal women with a history of bilateral oophorectomy prior to natural menopause (surgical menopause) have a higher risk of nonvertebral, postmenopausal fracture than women with natural menopause. Methods We used 21 years of prospectively collected incident fracture data from the ongoing Study of Osteoporotic Fractures (SOF), a cohort study of community dwelling women without previous bilateral hip fracture who were age 65 or older at enrollment, to determine the risk of hip, wrist, and any nonvertebral fracture. Chi square and t-tests were used to compare the two groups on important characteristics. Multivariable Cox proportional hazards regression models stratified by baseline oral estrogen use status were used to estimate the risk of fracture. Results Baseline characteristics differed significantly between the 6,616 women within SOF who underwent either surgical (1,157) or natural (5,459) menopause, including mean age at menopause (44.3 ±7.4 versus 48.9 ±4.9 years, p<.001) and current use of oral estrogen (30.2% vs 6.5%, p<.001). Fracture rates were not significantly increased for surgical versus natural menopause, even among women who had never used oral estrogen (hip fracture, hazard ratio [HR] 0.87, 95% confidence interval [CI] 0.63–1.21; wrist fracture HR 1.10, 95% CI 0.78–1.57; any nonvertebral fracture HR 1.11, 95% CI 0.93–1.32). Conclusion These data provide some reassurance that the long-term risk of nonvertebral fracture is not substantially increased for postmenopausal women who experienced premenopausal bilateral oophorectomy, compared to postmenopausal women with intact ovaries, even in the absence of postmenopausal estrogen therapy.

show abstract

“…Unlike breast or cervical cancer, however, no effective and reliable screening measures exist for ovarian cancer, resulting in delayed detection (Buys et al, 2005; Calonge & US Preventive Services Task Force, 2004; Horner et al, 2009). Additionally, ovarian cancer often exhibits very few early symptoms (Jacobs & Menon, 2004).…”

Section: Introductionmentioning

confidence: 99%

Racial differences in stage at diagnosis and survival from epithelial ovarian cancer: A fundamental cause of disease approach

Kim

Dolecek

Davis

2010

Social Science & Medicine

View full text Add to dashboard Cite

Associations between race, socioeconomic status (SES) and health outcomes have been well established. One of the ways in which race and SES affect health is by influencing one’s access to resources, which confers ability to avoid or mitigate adverse outcomes. The fundamental cause of disease approach argues that when a new screening tool is introduced, individuals with greater resources tend to have better access to the innovation, thus benefiting from early detection and leading to better survival. Conversely, when there is no established screening tool, racial and SES differences in early detection may be less pronounced. Most ovarian cancer is diagnosed at advanced stages, because of the lack of an effective screening tool and few early symptoms. However, once detected, racial differences may still be observed in mortality and survival outcomes. We examined the racial differences in diagnosis and survival among ovarian cancer cases diagnosed during 1994–1998, in Cook County, Illinois (N=351). There were no racial differences in the stage at diagnosis: 51.7% of white and 52.9% of black women were diagnosed at later stages (III and IV). Only age was associated with the stage at diagnosis. Tumor characteristics also did not differ between white and black women. Compared to white women, black women were less likely to be married, less educated, more frequently used genital powder, had tubal ligation, and resided in higher poverty census tracts. As of December 31, 2005, 44.3% of white and 54.5% of black women had died of ovarian cancer. Controlling for known confounding variables, the hazard ratio for ovarian cancer death between black and white women was 2.2. The findings show that fundamental cause perspective provides a potential framework to explore subtleties in racial disparities, with which broader social causes may be accounted for in explaining post diagnosis racial differences.

show abstract

Screening for Ovarian Cancer: Recommendation Statement

Cited by 66 publications

References 21 publications

Update in Women’s Health for the General Internist

Update in Women’s Health for the General Internist

Surgical menopause and nonvertebral fracture risk among older US women

Racial differences in stage at diagnosis and survival from epithelial ovarian cancer: A fundamental cause of disease approach

Contact Info

Product

Resources

About