Screening for prodromal adolescents in an isolated high-risk population

Ord, Lisa M.; Myles-Worsley, Marina; Blailes, Francisca; Ngiralmau, Hilda

doi:10.1016/j.schres.2004.03.014

Cited by 68 publications

(51 citation statements)

References 7 publications

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“…Cost-effective general screening tools like the CBCL or BASC-2 could represent an initial stage in a two-step screening process. After an individual has been identified to be at risk given their profile, the second step would be administration of psychosis-specific instruments like the SIPS, the Prodromal Questionnaire – Brief Version (PQ-B; NEW REF - Loewy et al, 2011), Prime Screen – Revised (PS-R; Miller et al, 2004), or Youth Psychosis At Risk Questionnaire – Brief (YPARQ-B; Ord et al, 2004). This psychosis screening strategy would potentially streamline the process of early detection and treatment of youth at the highest possible risk for development of psychosis, reduce the unwanted effects of stigma, and potentially increase the precision of psychosis-risk screening.…”

Section: Discussionmentioning

confidence: 99%

Psychosis risk screening in clinical high-risk adolescents: A longitudinal investigation using the Child Behavior Checklist

Simeonova

Nguyen

Walker

2014

Schizophrenia Research

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This is the first study to investigate whether parent-reported social and behavioral problems on the Child Behavior Checklist (CBCL) can be used for psychosis risk screening and the identification of at-risk youth in the general population. This longitudinal investigation assessed 122 adolescent participants from three groups (at-risk, other personality disorders, nonpsychiatric controls) at baseline and one year follow-up. The findings indicate that two individual CBCL rating scales, Withdrawn/Depressed and Thought Problems, have clinical and diagnostic utility as an adjunctive risk screening measure to aid in early detection of at-risk youth likely to develop psychosis. Furthermore, the findings shows that a cost-effective, general screening tool with a widespread use in community and pediatric healthcare settings has a promise to serve as a first step in a multi-stage risk screening process. This can potentially facilitate increased screening precision and reduction of high rate of false-positives in clinical high-risk individuals who present with elevated scores on psychosis-risk measures, but ultimately do not go on to develop psychosis. The findings of the present study also have significant clinical and research implications for the development of a broad-based psychosis risk screening strategy, and novel prevention and early intervention approaches in at-risk populations for the emergence of severe mental illness.

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Section: Discussionmentioning

confidence: 99%

Psychosis risk screening in clinical high-risk adolescents: A longitudinal investigation using the Child Behavior Checklist

Simeonova

Nguyen

Walker

2014

Schizophrenia Research

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“…Assessment and screening tools that identify prodromal states can be critical in early intervention and prevention of psychotic episodes. Self-report questionnaire screening tools are an effective way to conduct community-wide screening of adolescents for prodromal or at-risk mental states, particularly with non-helping-seeking adolescents, as it is "an important adjunct to genetic high risk strategies for identifying early psychosis" (Myles-Worsley et al, 2007, p. 4;Ord et al, 2004). A major concern, however, is the nonspecific nature of the symptoms associated with schizophrenia, which are indistinguishable from other dimensions of psychopathology (Hafner et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Youth Psychosis At Risk Questionnaire (Y-PARQ; Ord et al, 2004). The Y-PARQ, based on the CAARMS (Yung et al, 2006), consists of 92 self-report (yes/no) items covering positive, affective, and negative symptoms.…”

Section: Screening Instrumentsmentioning

confidence: 99%

“…In a community-wide screening in Palau, high scores on the 24 most discriminating positive symptom items discriminated between normal and potentially prodromal adolescents. The Y-PARQ positive symptom score had a positive predictive value of 82% for identifying early psychosis, before reaching the UHR status (Ord et al, 2004). The researchers stated that a self-report questionnaire administered in high schools is an effective way to conduct community-wide screening of adolescents for prodromal symptomatology (Myles-Worsley et al, 2007).…”

Section: Screening Instrumentsmentioning

confidence: 99%

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Identifying, Assessing, and Treating Early Onset Schizophrenia at School

Pearrow

Jimerson

2010

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“…The Y-PARQ is an instrument with 92 items to which the respondent can answer “yes,” “no,” or “unknown.” It was based on the CAARMS and was developed for the PEPS study, which investigated teens on Palau, a Pacific island where there is a high frequency of familial schizophrenia (Ord et al, 2004; Myles-Worsley et al, 2007a,b). At the time of writing, no publication had yet reported rates of conversion to psychosis associated with the Y-PARQ.…”

Section: Resultsmentioning

confidence: 99%

Genealogy of instruments for prodrome evaluation of psychosis

Daneault

Stip

2013

Front. Psychiatry

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Objective: Over the last 15 years, researchers from around the world have developed instruments for assessing the risk of conversion to psychosis. The objective of this article is to review the literature on these instruments by focusing on genealogy links and on their performance in predicting conversion to psychosis.Method: A systematic review of articles published since 1980 relating to risk assessment instruments for conversion to psychosis by manual search and consultation of electronic databases MEDLINE, EMBASE, and PsycINFO.Results: Three hundred ninety one (391) publications were selected and analyzed. Among these, 22 instruments were identified. These instruments are briefly described and placed on a timeline according to their year of publication. A code of positions, patterns, and forms is used to schematize the characteristics of each instrument. A table is presented to show changes in rates of conversion to psychosis within cohorts of subjects considered at risk according to the instruments. A second code of shades and outlines is used to schematize the characteristics of each cohort of patients. The two graphics set the stage for a discussion about the major strategies that were adopted to improve the performance of risk assessment instruments.Conclusion: These graphics allow a better understanding of the origin, evolution, current status, strengths, shortcomings, and future prospects of research on risk assessment instruments.Clinical Implications The integration of theoretical approaches, the multicenter studies, and the pre-selection of patients with short questionnaires were the main strategies to improve the performance of instruments assessing the risk of conversion to psychosis.These instruments are better at predicting conversion to psychosis than conventional variables within a more limited time span and can therefore enable the evaluation of various risk factors and biomarkers that may be associated with psychosis.Limitations The studies selected for this review of literature were not classified according to their methodological quality.These studies are based on heterogeneous populations and this must be taken into account when comparing the rates of conversion to psychosis.This review of literature was based on published data only and they were no direct communication with the authors of these instruments.

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Screening for prodromal adolescents in an isolated high-risk population

Cited by 68 publications

References 7 publications

Psychosis risk screening in clinical high-risk adolescents: A longitudinal investigation using the Child Behavior Checklist

Psychosis risk screening in clinical high-risk adolescents: A longitudinal investigation using the Child Behavior Checklist

Identifying, Assessing, and Treating Early Onset Schizophrenia at School

Genealogy of instruments for prodrome evaluation of psychosis

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